Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45711 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Melecular. Rio de Janeiro, RJ, Brasil. |
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Araujo, Natalia M.Teles, Sheila A.Spitz, Natália2021-01-15T13:08:54Z2021-01-15T13:08:54Z2020ARAUJO, Natalia M.; TELES, Sheila A.; SPITZ, Natália. Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region. Frontiers in Microbiology, v. 11, Article 616023, p. 1-22, Dec. 2020.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/4571110.3389/fmicb.2020.616023engFrontiers MediaVírus da Hepatite BGenótiposMutaçãoFuga imunológicaResistência antiviralCarcinoma hepatocelularEvolução do HBVSeleção naturalHepatitis B virusGenotypesMutationImmune escapeAntiviral resistanceHepatocellular carcinomaHBV evolutionNatural selectionComprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Melecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Melecular. Rio de Janeiro, RJ, Brasil.Hepatitis B virus (HBV) is a highly variable DNA virus due to its unique life cycle, which involves an error-prone reverse transcriptase. The high substitution rate drives the evolution of HBV by generating genetic variants upon which selection operates. HBV mutants with clinical implications have been documented worldwide, indicating the potential for spreading and developing their own epidemiology. However, the prevalence of such mutants among the different HBV genotypes and subgenotypes has not been systematically analyzed. In the current study, we performed large-scale analysis of 6,479 full-length HBV genome sequences from genotypes A-H, with the aim of gaining comprehensive insights into the relationships of relevant mutations associated with immune escape, antiviral resistance and hepatocellular carcinoma (HCC) development with HBV (sub)genotypes and geographic regions. Immune escape mutations were detected in 10.7% of the sequences, the most common being I/T126S (1.8%), G145R (1.2%), M133T (1.2%), and Q129R (1.0%). HBV genotype B showed the highest rate of escape mutations (14.7%) while genotype H had no mutations (P < 0.001). HCC-associated mutations were detected in 33.7% of the sequences, with significantly higher frequency of C1653T, T1753V and A1762T/G1764A in genotype G than C (P < 0.001). The overall frequencies of lamivudine-, telbivudine-, adefovir-, and entecavir-resistant mutants were 7.3, 7.2, 0.5, and 0.2%, respectively, while only 0.05% showed reduced susceptibility to tenofovir. In particular, the highest frequency of lamivudine-resistant mutations was observed in genotype G and the lowest frequency in genotype E (32.5 and 0.3%; P < 0.001). The prevalence of HBV mutants was also biased by geographic location, with North America identified as one of the regions with the highest rates of immune escape, antiviral resistance, and HCC-associated mutants. The collective findings were discussed in light of natural selection and the known characteristics of HBV (sub)genotypes. Our data provide relevant information on the prevalence of clinically relevant HBV mutations, which may contribute to further improvement of diagnostic procedures, immunization programs, therapeutic protocols, and disease prognosis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45711/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNataliaMAraujo_NataliaSpitz_etal_IOC_2020.pdfNataliaMAraujo_NataliaSpitz_etal_IOC_2020.pdfapplication/pdf3218136https://www.arca.fiocruz.br/bitstream/icict/45711/2/NataliaMAraujo_NataliaSpitz_etal_IOC_2020.pdfe36828ac71323795804986df9a13eb35MD52TEXTNataliaMAraujo_NataliaSpitz_etal_IOC_2020.pdf.txtNataliaMAraujo_NataliaSpitz_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region |
title |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region |
spellingShingle |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region Araujo, Natalia M. Vírus da Hepatite B Genótipos Mutação Fuga imunológica Resistência antiviral Carcinoma hepatocelular Evolução do HBV Seleção natural Hepatitis B virus Genotypes Mutation Immune escape Antiviral resistance Hepatocellular carcinoma HBV evolution Natural selection |
title_short |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region |
title_full |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region |
title_fullStr |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region |
title_full_unstemmed |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region |
title_sort |
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region |
author |
Araujo, Natalia M. |
author_facet |
Araujo, Natalia M. Teles, Sheila A. Spitz, Natália |
author_role |
author |
author2 |
Teles, Sheila A. Spitz, Natália |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Araujo, Natalia M. Teles, Sheila A. Spitz, Natália |
dc.subject.other.pt_BR.fl_str_mv |
Vírus da Hepatite B Genótipos Mutação Fuga imunológica Resistência antiviral Carcinoma hepatocelular Evolução do HBV Seleção natural |
topic |
Vírus da Hepatite B Genótipos Mutação Fuga imunológica Resistência antiviral Carcinoma hepatocelular Evolução do HBV Seleção natural Hepatitis B virus Genotypes Mutation Immune escape Antiviral resistance Hepatocellular carcinoma HBV evolution Natural selection |
dc.subject.en.pt_BR.fl_str_mv |
Hepatitis B virus Genotypes Mutation Immune escape Antiviral resistance Hepatocellular carcinoma HBV evolution Natural selection |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Melecular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-01-15T13:08:54Z |
dc.date.available.fl_str_mv |
2021-01-15T13:08:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ARAUJO, Natalia M.; TELES, Sheila A.; SPITZ, Natália. Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region. Frontiers in Microbiology, v. 11, Article 616023, p. 1-22, Dec. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45711 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-302X |
dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2020.616023 |
identifier_str_mv |
ARAUJO, Natalia M.; TELES, Sheila A.; SPITZ, Natália. Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region. Frontiers in Microbiology, v. 11, Article 616023, p. 1-22, Dec. 2020. 1664-302X 10.3389/fmicb.2020.616023 |
url |
https://www.arca.fiocruz.br/handle/icict/45711 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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