MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients

Detalhes bibliográficos
Autor(a) principal: Mesquita, Carolina D'Avila
Data de Publicação: 2021
Outros Autores: Couto, Ariel E. S., Campos, Ligia C. B., Vasconcelos, Tauana P., Barbosa, Jessyca Michelon, Corsi, Carlos A. C., Mestriner, Fabiola, Moraes, Bruno C. Petroski, Garbellini-Diab, Maria J., Couto, Daniel M. S., Jordani, Maria C., Ferro, Denise, Sbragia, Lourenço, Joviliano, Edwaldo E., Evora, Paulo R., Santana, Rodrigo de Carvalho, Martins Filho, Olindo Assis, Polonis, Katarzyna, Menegueti, Mayra G., Ribeiro, Mauricio S., Martins, Maria Auxiliadora, Becari, Christiane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50779
Resumo: Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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spelling Mesquita, Carolina D'AvilaCouto, Ariel E. S.Campos, Ligia C. B.Vasconcelos, Tauana P.Barbosa, Jessyca MichelonCorsi, Carlos A. C.Mestriner, FabiolaMoraes, Bruno C. PetroskiGarbellini-Diab, Maria J.Couto, Daniel M. S.Jordani, Maria C.Ferro, DeniseSbragia, LourençoJoviliano, Edwaldo E.Evora, Paulo R.Santana, Rodrigo de CarvalhoMartins Filho, Olindo AssisPolonis, KatarzynaMenegueti, Mayra G.Ribeiro, Mauricio S.Martins, Maria AuxiliadoraBecari, Christiane2022-01-17T01:39:48Z2022-01-17T01:39:48Z2021MESQUITA, Carolina D'Avila et al. MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients. Biomedicine and Pharmacotherapy, v. 142, p. 1-10, Oct. 2021.0753-3322https://www.arca.fiocruz.br/handle/icict/5077910.1016/j.biopha.2021.112067Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Fundaçao ˜ de Amparo a ` Pesquisa do Estado de Sao ˜ Paulo (FAPESP), Brazil supported: Christiane Becari (2017/21539-7; 2018/23718-8), Mauricio S. Ribeiro (2019/11485-1), Maria Auxiliadora Martins (2019/11485-1), Carolina D`Avila-Mesquita (2019/24369-0), Ariel E. S. Couto (2020/03308-0), Ligia C.B. Campos (2020/09999-4), Bruno C.P. Moraes (2021/01195-6), Jessyca M. Barbosa (2019/21721-4). CNPq, Brazil supported Maria Julia Garbellini Diab (137525/2020-6).Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cuidados Intensivos. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cuidados Intensivos.Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Cardíaca. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Pediátrica. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Cardíaca. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Mayo Clinic. Department of Laboratory Medicine and Pathology. Rochester, MN, USA.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cuidados Intensivos. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cuidados Intensivos. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular e Endovascular. Ribeirão Preto, SP, Brasil.Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography. The study groups were matched for age, sex, hypertension, diabetes, BMI, and obesity profile. MMP-2 levels were lower and MMP-9 levels were higher in a COVID-19 group (p < 0.0001) compared to Controls. MMP-9 levels in COVID-19 patients were not affected by comorbidity such as hypertension or obesity. MMP-2 levels were affected by hypertension (p < 0.05), but unaffected by obesity status. Notably, hypertensive COVID-19 patients had higher MMP-2 levels compared to the non-hypertensive COVID-19 group, albeit still lower than Controls (p < 0.05). No association between MMP-2 and MMP-9 plasmatic levels and corticosteroid treatment or acute kidney injury was found in COVID-19 patients. The survival analysis showed that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP-2 and MMP-9 were better predictors of mortality during hospitalization than SAPS3 and SOFA scores at hospital admission. In conclusion, a significant association between MMP-2 and MMP-9 levels and COVID-19 was found. Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles.engElsevierMMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSARS-COV2 infectionCOVID-19MetalloproteinasesMMP-2MMP-9PathophysiologyCOVID-19SARS-CoV-2info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50779/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALD`Avila-Mesquita_Carolina_etal_IRR_COVID-19_2021.pdfD`Avila-Mesquita_Carolina_etal_IRR_COVID-19_2021.pdfapplication/pdf3118321https://www.arca.fiocruz.br/bitstream/icict/50779/2/D%60Avila-Mesquita_Carolina_etal_IRR_COVID-19_2021.pdfd7ec8c95d0a649da5b54c8586c4026a1MD52icict/507792023-02-15 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dc.title.en_US.fl_str_mv MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
title MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
spellingShingle MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
Mesquita, Carolina D'Avila
SARS-COV2 infection
COVID-19
Metalloproteinases
MMP-2
MMP-9
Pathophysiology
COVID-19
SARS-CoV-2
title_short MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
title_full MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
title_fullStr MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
title_full_unstemmed MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
title_sort MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
author Mesquita, Carolina D'Avila
author_facet Mesquita, Carolina D'Avila
Couto, Ariel E. S.
Campos, Ligia C. B.
Vasconcelos, Tauana P.
Barbosa, Jessyca Michelon
Corsi, Carlos A. C.
Mestriner, Fabiola
Moraes, Bruno C. Petroski
Garbellini-Diab, Maria J.
Couto, Daniel M. S.
Jordani, Maria C.
Ferro, Denise
Sbragia, Lourenço
Joviliano, Edwaldo E.
Evora, Paulo R.
Santana, Rodrigo de Carvalho
Martins Filho, Olindo Assis
Polonis, Katarzyna
Menegueti, Mayra G.
Ribeiro, Mauricio S.
Martins, Maria Auxiliadora
Becari, Christiane
author_role author
author2 Couto, Ariel E. S.
Campos, Ligia C. B.
Vasconcelos, Tauana P.
Barbosa, Jessyca Michelon
Corsi, Carlos A. C.
Mestriner, Fabiola
Moraes, Bruno C. Petroski
Garbellini-Diab, Maria J.
Couto, Daniel M. S.
Jordani, Maria C.
Ferro, Denise
Sbragia, Lourenço
Joviliano, Edwaldo E.
Evora, Paulo R.
Santana, Rodrigo de Carvalho
Martins Filho, Olindo Assis
Polonis, Katarzyna
Menegueti, Mayra G.
Ribeiro, Mauricio S.
Martins, Maria Auxiliadora
Becari, Christiane
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mesquita, Carolina D'Avila
Couto, Ariel E. S.
Campos, Ligia C. B.
Vasconcelos, Tauana P.
Barbosa, Jessyca Michelon
Corsi, Carlos A. C.
Mestriner, Fabiola
Moraes, Bruno C. Petroski
Garbellini-Diab, Maria J.
Couto, Daniel M. S.
Jordani, Maria C.
Ferro, Denise
Sbragia, Lourenço
Joviliano, Edwaldo E.
Evora, Paulo R.
Santana, Rodrigo de Carvalho
Martins Filho, Olindo Assis
Polonis, Katarzyna
Menegueti, Mayra G.
Ribeiro, Mauricio S.
Martins, Maria Auxiliadora
Becari, Christiane
dc.subject.en.en_US.fl_str_mv SARS-COV2 infection
COVID-19
Metalloproteinases
MMP-2
MMP-9
topic SARS-COV2 infection
COVID-19
Metalloproteinases
MMP-2
MMP-9
Pathophysiology
COVID-19
SARS-CoV-2
dc.subject.en.none.fl_str_mv Pathophysiology
dc.subject.decs.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
description Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-17T01:39:48Z
dc.date.available.fl_str_mv 2022-01-17T01:39:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MESQUITA, Carolina D'Avila et al. MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients. Biomedicine and Pharmacotherapy, v. 142, p. 1-10, Oct. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50779
dc.identifier.issn.pt_BR.fl_str_mv 0753-3322
dc.identifier.doi.none.fl_str_mv 10.1016/j.biopha.2021.112067
identifier_str_mv MESQUITA, Carolina D'Avila et al. MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients. Biomedicine and Pharmacotherapy, v. 142, p. 1-10, Oct. 2021.
0753-3322
10.1016/j.biopha.2021.112067
url https://www.arca.fiocruz.br/handle/icict/50779
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50779/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50779/2/D%60Avila-Mesquita_Carolina_etal_IRR_COVID-19_2021.pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
d7ec8c95d0a649da5b54c8586c4026a1
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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