Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
Autor(a) principal: | |
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Data de Publicação: | 1990 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33564 |
Resumo: | Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Pirmez, ClaudeOliveira Neto, Manoel PaesGrimaldi Jr., GabrielSavino, Wilson2019-06-18T17:42:42Z2019-06-18T17:42:42Z1990PIRMEZ, Claude et al. Immunopathology of american cutaneous leishmaniasis. Modulation of MHC class II gene products by Keratinocytes before and after glucantime therapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 2, p. 203-209, Apr./June 1990.0074-0276https://www.arca.fiocruz.br/handle/icict/3356410.1590/S0074-027619900002000111678-8060engFiocruz/IOCLeishmanioseQueratinócitosTerapia GlucamtimeLeishmaniasisKeratinocytesHLA-DRGlucamtime therapyImmunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Epidermal changes from 32 cutaneous and 3 mucosal American leishmaniasis (ACL) active lesions were studied for HLA-DR, -DP expression, Lanerhans cells and lymphocyte infiltration. In addition to a DR and DQ positivity at the surface of the cells of the inflammatory infiltrate, a strong reaction for DR antigens was detected on keratinocytes. Hyperplasia of Langerhans cells was present in al cutaneous lesions and epidermis was infiltrated by T lymphocytes. When healed lesions of 14 of these subjects were re-biopsied 1 to 12 months after the end of pentavalent antimonial therapy, MHC class antigens could no longer be seen on keratinocytes. Our data represrn evidence for hhe reversibility of the abnormal HLA-DR expression by keratinocytes in ACL after Glucantime therapy or spontaneous scar formation, demonstrating that this expresion is restricted to the period of active lesions. The present findings can be regarded as an indirect evidence that keratinocytes may be involved in the immunopathology of ACL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33564/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdfWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdfapplication/pdf1864157https://www.arca.fiocruz.br/bitstream/icict/33564/2/WilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf86b0e8c79e3ba61ee022b8a6a368f54cMD52TEXTWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf.txtWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/33564/3/WilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf.txt212b0306580d4f0044d18f9a3edcc832MD53icict/335642023-10-25 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dc.title.pt_BR.fl_str_mv |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy |
title |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy |
spellingShingle |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy Pirmez, Claude Leishmaniose Queratinócitos Terapia Glucamtime Leishmaniasis Keratinocytes HLA-DR Glucamtime therapy |
title_short |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy |
title_full |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy |
title_fullStr |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy |
title_full_unstemmed |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy |
title_sort |
Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy |
author |
Pirmez, Claude |
author_facet |
Pirmez, Claude Oliveira Neto, Manoel Paes Grimaldi Jr., Gabriel Savino, Wilson |
author_role |
author |
author2 |
Oliveira Neto, Manoel Paes Grimaldi Jr., Gabriel Savino, Wilson |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pirmez, Claude Oliveira Neto, Manoel Paes Grimaldi Jr., Gabriel Savino, Wilson |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Queratinócitos Terapia Glucamtime |
topic |
Leishmaniose Queratinócitos Terapia Glucamtime Leishmaniasis Keratinocytes HLA-DR Glucamtime therapy |
dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Keratinocytes HLA-DR Glucamtime therapy |
description |
Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
publishDate |
1990 |
dc.date.issued.fl_str_mv |
1990 |
dc.date.accessioned.fl_str_mv |
2019-06-18T17:42:42Z |
dc.date.available.fl_str_mv |
2019-06-18T17:42:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PIRMEZ, Claude et al. Immunopathology of american cutaneous leishmaniasis. Modulation of MHC class II gene products by Keratinocytes before and after glucantime therapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 2, p. 203-209, Apr./June 1990. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/33564 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02761990000200011 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
PIRMEZ, Claude et al. Immunopathology of american cutaneous leishmaniasis. Modulation of MHC class II gene products by Keratinocytes before and after glucantime therapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 2, p. 203-209, Apr./June 1990. 0074-0276 10.1590/S0074-02761990000200011 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/33564 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fiocruz/IOC |
publisher.none.fl_str_mv |
Fiocruz/IOC |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
institution |
FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
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repositorio.arca@fiocruz.br |
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