Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44596 |
Resumo: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)—(Finance Code 001) (RPS, SCMAY and SPC). The study was also supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (470959/2014-2 and 405595/2016-6) through a grant to MSG. |
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Santiago, Rayra P.Figueiredo, Camylla V. B.Fiuza, Luciana M.Yahouédéhou, Sètondji C. M. A.Oliveira, Rodrigo M.Aleluia, Milena M.Carvalho, Suellen P.Fonseca, Cleverson A.Nascimento, Valma M. L.Rocha, Larissa C.Guarda, Caroline ConceiçãoGonçalves, Marilda de Souza2020-11-24T13:50:12Z2020-11-24T13:50:12Z2020SANTIAGO, Rayra P. et al. Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations. Mediators of Inflammation, 2020.0962-9351https://www.arca.fiocruz.br/handle/icict/4459610.1155/2020/3185015Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)—(Finance Code 001) (RPS, SCMAY and SPC). The study was also supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (470959/2014-2 and 405595/2016-6) through a grant to MSG.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia do Estado da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia do Estado da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 (TGFBR3) gene have been linked to several inflammatory diseases. This study investigated associations between two TGFBR3 haplotypes and classical laboratory parameters, as well as clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia. Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and CGG haplotypes of TGFBR3 present important alterations in lipid profile.engHindawiFator de Crescimento Transformador alfaAnemia falciformePneumoniaHaplotiposTransforming Growth Factor alphaAnemia, Sickle CellPneumoniaHaplotypesTransforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/44596/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSantiago, Rayra P. Trasnforming....pdfSantiago, Rayra P. 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| dc.title.pt_BR.fl_str_mv |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| spellingShingle |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations Santiago, Rayra P. Fator de Crescimento Transformador alfa Anemia falciforme Pneumonia Haplotipos Transforming Growth Factor alpha Anemia, Sickle Cell Pneumonia Haplotypes |
| title_short |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_full |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_fullStr |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_full_unstemmed |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_sort |
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| author |
Santiago, Rayra P. |
| author_facet |
Santiago, Rayra P. Figueiredo, Camylla V. B. Fiuza, Luciana M. Yahouédéhou, Sètondji C. M. A. Oliveira, Rodrigo M. Aleluia, Milena M. Carvalho, Suellen P. Fonseca, Cleverson A. Nascimento, Valma M. L. Rocha, Larissa C. Guarda, Caroline Conceição Gonçalves, Marilda de Souza |
| author_role |
author |
| author2 |
Figueiredo, Camylla V. B. Fiuza, Luciana M. Yahouédéhou, Sètondji C. M. A. Oliveira, Rodrigo M. Aleluia, Milena M. Carvalho, Suellen P. Fonseca, Cleverson A. Nascimento, Valma M. L. Rocha, Larissa C. Guarda, Caroline Conceição Gonçalves, Marilda de Souza |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santiago, Rayra P. Figueiredo, Camylla V. B. Fiuza, Luciana M. Yahouédéhou, Sètondji C. M. A. Oliveira, Rodrigo M. Aleluia, Milena M. Carvalho, Suellen P. Fonseca, Cleverson A. Nascimento, Valma M. L. Rocha, Larissa C. Guarda, Caroline Conceição Gonçalves, Marilda de Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Fator de Crescimento Transformador alfa Anemia falciforme Pneumonia Haplotipos |
| topic |
Fator de Crescimento Transformador alfa Anemia falciforme Pneumonia Haplotipos Transforming Growth Factor alpha Anemia, Sickle Cell Pneumonia Haplotypes |
| dc.subject.en.pt_BR.fl_str_mv |
Transforming Growth Factor alpha Anemia, Sickle Cell Pneumonia Haplotypes |
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)—(Finance Code 001) (RPS, SCMAY and SPC). The study was also supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (470959/2014-2 and 405595/2016-6) through a grant to MSG. |
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2020 |
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2020-11-24T13:50:12Z |
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2020-11-24T13:50:12Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SANTIAGO, Rayra P. et al. Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations. Mediators of Inflammation, 2020. |
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https://www.arca.fiocruz.br/handle/icict/44596 |
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0962-9351 |
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10.1155/2020/3185015 |
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SANTIAGO, Rayra P. et al. Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations. Mediators of Inflammation, 2020. 0962-9351 10.1155/2020/3185015 |
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Hindawi |
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Hindawi |
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