Smell dysfunction in COVID-19 patients: More than a yes-no question

Detalhes bibliográficos
Autor(a) principal: Lima, Marco A.
Data de Publicação: 2020
Outros Autores: Silva, Marcus Tulius T., Oliveira, Raquel V., Soares, Cristiane N., Takano, Crissi L., Azevedo, Anna E., Moraes, Raissa L., Rezende, Rafaela B., Chagas, Ingrid T., Espíndola, Otávio, Leite, Ana Claudia, Araujo, Abelardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43160
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Seção de Neurologia. Rio de Janeiro, RJ, Brasil.
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spelling Lima, Marco A.Silva, Marcus Tulius T.Oliveira, Raquel V.Soares, Cristiane N.Takano, Crissi L.Azevedo, Anna E.Moraes, Raissa L.Rezende, Rafaela B.Chagas, Ingrid T.Espíndola, OtávioLeite, Ana ClaudiaAraujo, Abelardo2020-09-02T14:27:50Z2020-09-02T14:27:50Z2020LIMA, Marco A. et al. Smell dysfunction in COVID-19 patients: More than a yes-no question. Journal of the Neurological Sciences, v. 418, p. 1-3, 2020.0022-510Xhttps://www.arca.fiocruz.br/handle/icict/4316010.1016/j.jns.2020.117107engElsevierSmell dysfunction in COVID-19 patients: More than a yes-no questioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Seção de Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Complexo Hospitalar de Niterói. Departamento de Neurologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Complexo Hospitalar de Niterói. Departamento de Neurologia. Niterói, RJ, Brasil / Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Neurologia. Rio de Janeiro, RJ, Brasil.Anosmia has been recognized as a prevalent and early symptom by many COVID-19 patients. However, most researchers have recorded smell dysfunction solely as present or absent and based on subjective evaluation by patients. We described the results of 57 consecutive COVID-19 patients seen at FIOCRUZ, Rio de Janeiro, Brazil, from April to May 2020. Data about the presence of smell loss, the onset of smell loss and other COVID-19 symptoms such as ageusia and nasal congestion or rhinorrhea were recorded. All patients at the initial consultation and 34 healthy controls underwent the Q-SIT, which is a quick disposable three-item smell identification test, by a trained physician. We compared three groups: healthy controls, COVID+ patients with reported smell loss (COVID w/ SL) and COVID+ patients without smell loss (COVID+ w/o SL). The mean age of patients was 41.4 years (SD ± 10.4), and 54.4% were women. Smell loss was reported by 40.4% of COVID-19 patients. We observed a gradual effect with higher Q-SIT scores in healthy controls, followed by COVID+ w/o SL and COVID+ w/ SL (medians = 3, 2 and 0; respectively, p < 0.001). Anosmia or severe microsmia (Q-SIT≤1) was present in 11.1% (CI: 3.1%-26.1%) of controls, 32.4% (CI: 17.4%-50.5%) of COVID-19 w/o SL and 87% (CI: 66.4%-97.2%) of COVID+ w/ SL (p < 0.001). This study provides evidence that olfactory dysfunction in COVID-19 is common and more prevalent than what is perceived by patients. Q-SIT is a quick and reliable screening test for the detection of smell dysfunction during the pandemics.COVID-19Central nervous system viral diseasesOlfaction disordersinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/43160/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALLima_Marco_etal_INI_2020_COVID-19.pdfLima_Marco_etal_INI_2020_COVID-19.pdfapplication/pdf659879https://www.arca.fiocruz.br/bitstream/icict/43160/2/Lima_Marco_etal_INI_2020_COVID-19.pdf8ea3e6da6b5771e153d176c2b25f49d1MD52TEXTLima_Marco_etal_INI_2020_COVID-19.pdf.txtLima_Marco_etal_INI_2020_COVID-19.pdf.txtExtracted texttext/plain13538https://www.arca.fiocruz.br/bitstream/icict/43160/3/Lima_Marco_etal_INI_2020_COVID-19.pdf.txt3799f9e67e2f9a4a850fc0fa9cde1325MD53icict/431602020-09-03 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dc.title.pt_BR.fl_str_mv Smell dysfunction in COVID-19 patients: More than a yes-no question
title Smell dysfunction in COVID-19 patients: More than a yes-no question
spellingShingle Smell dysfunction in COVID-19 patients: More than a yes-no question
Lima, Marco A.
COVID-19
Central nervous system viral diseases
Olfaction disorders
title_short Smell dysfunction in COVID-19 patients: More than a yes-no question
title_full Smell dysfunction in COVID-19 patients: More than a yes-no question
title_fullStr Smell dysfunction in COVID-19 patients: More than a yes-no question
title_full_unstemmed Smell dysfunction in COVID-19 patients: More than a yes-no question
title_sort Smell dysfunction in COVID-19 patients: More than a yes-no question
author Lima, Marco A.
author_facet Lima, Marco A.
Silva, Marcus Tulius T.
Oliveira, Raquel V.
Soares, Cristiane N.
Takano, Crissi L.
Azevedo, Anna E.
Moraes, Raissa L.
Rezende, Rafaela B.
Chagas, Ingrid T.
Espíndola, Otávio
Leite, Ana Claudia
Araujo, Abelardo
author_role author
author2 Silva, Marcus Tulius T.
Oliveira, Raquel V.
Soares, Cristiane N.
Takano, Crissi L.
Azevedo, Anna E.
Moraes, Raissa L.
Rezende, Rafaela B.
Chagas, Ingrid T.
Espíndola, Otávio
Leite, Ana Claudia
Araujo, Abelardo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Marco A.
Silva, Marcus Tulius T.
Oliveira, Raquel V.
Soares, Cristiane N.
Takano, Crissi L.
Azevedo, Anna E.
Moraes, Raissa L.
Rezende, Rafaela B.
Chagas, Ingrid T.
Espíndola, Otávio
Leite, Ana Claudia
Araujo, Abelardo
dc.subject.en.pt_BR.fl_str_mv COVID-19
Central nervous system viral diseases
Olfaction disorders
topic COVID-19
Central nervous system viral diseases
Olfaction disorders
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Seção de Neurologia. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-09-02T14:27:50Z
dc.date.available.fl_str_mv 2020-09-02T14:27:50Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Marco A. et al. Smell dysfunction in COVID-19 patients: More than a yes-no question. Journal of the Neurological Sciences, v. 418, p. 1-3, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43160
dc.identifier.issn.pt_BR.fl_str_mv 0022-510X
dc.identifier.doi.none.fl_str_mv 10.1016/j.jns.2020.117107
identifier_str_mv LIMA, Marco A. et al. Smell dysfunction in COVID-19 patients: More than a yes-no question. Journal of the Neurological Sciences, v. 418, p. 1-3, 2020.
0022-510X
10.1016/j.jns.2020.117107
url https://www.arca.fiocruz.br/handle/icict/43160
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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