Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul

Detalhes bibliográficos
Autor(a) principal: Bessa, Cibele Maria Alves da Silva
Data de Publicação: 2022
Outros Autores: Malafaia, Carolina Barbosa, Mercês, Paula Fernanda Figueiredo das, Araújo, Daniel Rodrigo Cavalcante de, Silva, Ana Paula Sant'Anna da, Lima, Vera Lúcia de Menezes, Batista, Fabiane Rabelo da Costa, Lima, Cláudia Sampaio de Andrade, Souza, Elineide Barbosa de, Correia, Maria Tereza dos Santos, Oliva, Maria Luiza Vilela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55252
Resumo: Universidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brasil.
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spelling Bessa, Cibele Maria Alves da SilvaMalafaia, Carolina BarbosaMercês, Paula Fernanda Figueiredo dasAraújo, Daniel Rodrigo Cavalcante deSilva, Ana Paula Sant'Anna daLima, Vera Lúcia de MenezesBatista, Fabiane Rabelo da CostaLima, Cláudia Sampaio de AndradeSouza, Elineide Barbosa deCorreia, Maria Tereza dos SantosOliva, Maria Luiza Vilela2022-10-23T21:22:10Z2022-10-23T21:22:10Z2022BESSA, Cibele Maria Alves da Silva et al. Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul. Revista Fitos, v. 16, n. 3, p. 324-334, sept. 2022.1808-9569https://www.arca.fiocruz.br/handle/icict/5525210.32712/2446-4775.2022.12652446-4775engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e SaúdeIsolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschulinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brasil.Centro de Tecnologias Estratégicas do Nordeste. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brasil.Ministério da Ciência, Tecnologia e Inovações. Instituto Nacional do Semiárido. Campina Grande, PB, Brasil.Universidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brasil.Ministério da Ciência, Tecnologia e Inovações. Instituto Nacional do Semiárido. Campina Grande, PB, Brasil.Universidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brasil.Universidade Federal Rural de Pernambuco. Departamento de Biologia. Recife, PE, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Bioquímica. Laboratório de Glicoproteínas. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Bioquímica. São Paulo, SP, Brasil.Several microorganisms are responsible for great economic losses in world agriculture. Preventive and treatment methods are applied to avoid contamination of crops by these microorganisms, however, the use of chemical antimicrobials damages health and the environment. Secondary plant metabolites are safe natural sources of antimicrobials for this application. Fabaceae family has its history described in the literature as a potential source for obtaining antimicrobial bioactive. The objective of this work was to isolate bioactive compounds guided by antimicrobial assays against bacteria and fungi in vitro. Organic extracts were prepared by eluotropic series of leaves of Anadenanthera colubrina var. cebil and were tested against six bacteria and six fungi phytopathogenic. The antimicrobial assays of minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) were performed at each purification step that occurred through HPLC-DAD, Flash Chromatography and HPLC-preparative analysis, to confirm the isolation of the bioactive. Through bioguided isolation, the compound p-hydroxybenzoic acid was obtained, which showed activity against the phytobacteria Xanthomonas campestris pv. campestris and Acidovorax citrulli.AngicoXanthomonas campestrisAcidovorax citrulliHPLC-DADFlash chromatographyHPLC-preparativeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/55252/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALc_m_a_et_all.pdfapplication/pdf675086https://www.arca.fiocruz.br/bitstream/icict/55252/2/c_m_a_et_all.pdfacbbfbf58095c345954e9cb3db28c1a5MD52icict/552522023-02-08 09:05:19.352oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-02-08T12:05:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
title Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
spellingShingle Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
Bessa, Cibele Maria Alves da Silva
Angico
Xanthomonas campestris
Acidovorax citrulli
HPLC-DAD
Flash chromatography
HPLC-preparative
title_short Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
title_full Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
title_fullStr Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
title_full_unstemmed Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
title_sort Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul
author Bessa, Cibele Maria Alves da Silva
author_facet Bessa, Cibele Maria Alves da Silva
Malafaia, Carolina Barbosa
Mercês, Paula Fernanda Figueiredo das
Araújo, Daniel Rodrigo Cavalcante de
Silva, Ana Paula Sant'Anna da
Lima, Vera Lúcia de Menezes
Batista, Fabiane Rabelo da Costa
Lima, Cláudia Sampaio de Andrade
Souza, Elineide Barbosa de
Correia, Maria Tereza dos Santos
Oliva, Maria Luiza Vilela
author_role author
author2 Malafaia, Carolina Barbosa
Mercês, Paula Fernanda Figueiredo das
Araújo, Daniel Rodrigo Cavalcante de
Silva, Ana Paula Sant'Anna da
Lima, Vera Lúcia de Menezes
Batista, Fabiane Rabelo da Costa
Lima, Cláudia Sampaio de Andrade
Souza, Elineide Barbosa de
Correia, Maria Tereza dos Santos
Oliva, Maria Luiza Vilela
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bessa, Cibele Maria Alves da Silva
Malafaia, Carolina Barbosa
Mercês, Paula Fernanda Figueiredo das
Araújo, Daniel Rodrigo Cavalcante de
Silva, Ana Paula Sant'Anna da
Lima, Vera Lúcia de Menezes
Batista, Fabiane Rabelo da Costa
Lima, Cláudia Sampaio de Andrade
Souza, Elineide Barbosa de
Correia, Maria Tereza dos Santos
Oliva, Maria Luiza Vilela
dc.subject.en.en_US.fl_str_mv Angico
Xanthomonas campestris
Acidovorax citrulli
HPLC-DAD
Flash chromatography
HPLC-preparative
topic Angico
Xanthomonas campestris
Acidovorax citrulli
HPLC-DAD
Flash chromatography
HPLC-preparative
description Universidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-23T21:22:10Z
dc.date.available.fl_str_mv 2022-10-23T21:22:10Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BESSA, Cibele Maria Alves da Silva et al. Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul. Revista Fitos, v. 16, n. 3, p. 324-334, sept. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55252
dc.identifier.issn.none.fl_str_mv 1808-9569
dc.identifier.doi.none.fl_str_mv 10.32712/2446-4775.2022.1265
dc.identifier.eissn.none.fl_str_mv 2446-4775
identifier_str_mv BESSA, Cibele Maria Alves da Silva et al. Isolation of active antiphytopathogen compound from extracts of Anadenanthera colubrina var. cebil (Griseb.) Altschul. Revista Fitos, v. 16, n. 3, p. 324-334, sept. 2022.
1808-9569
10.32712/2446-4775.2022.1265
2446-4775
url https://www.arca.fiocruz.br/handle/icict/55252
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/55252/2/c_m_a_et_all.pdf
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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