Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36900 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil. |
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Riccio, Lilian Rose PrattBaptista, Bárbara de OliveiraTorres, Vanessa RodriguesBianco Junior, CesareSilva, Daiana de Souza Perce daRiccio, Evelyn Kety PrattLima Junior, Josué da CostaTotino, Paulo Renato RivasCassiano, Gustavo CapattiMelo, Luciane Moreno StortiMachado, Ricardo Luiz DantasFerreira, Joseli de OliveiraBanic, Dalma MariaCarvalho, Leonardo José de MouraRibeiro, Cláudio Tadeu Daniel2019-11-06T14:38:44Z2019-11-06T14:38:44Z2019RICCIO, Lilian Rose Prat et al. Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3690010.1590/0074-027601900541678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.MaláriaPalsmodium vivaxProteína circum-esporozoitaQuimioresistênciaMalariaPalsmodium vivaxCircumsporozoite proteinChemoresistanceChloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Universidade de Campinas. Departamento de Genética, Evolução e Bioagentes. Laboratório de Doenças Tropicais, Campinas, SP, Brasil.Universidade Federal de Sergipe. Centro de Ciências Biológicas e da Saúde. Departamento de Biologia. Aracaju, SE, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.BACKGROUND The central repetitive region (CRR) of the Plasmodium vivax circumsporozoite surface protein (CSP) is composed of a repetitive sequence that is characterised by three variants: VK210, VK247 and P. vivax-like. The most important challenge in the treatment of P. vivax infection is the possibility of differential response based on the parasite genotype. OBJECTIVES To characterise the CSP variants in P. vivax isolates from individuals residing in a malaria-endemic region in Brazil and to profile these variants based on sensitivity to chloroquine and mefloquine. METHODS The CSP variants were determined by sequencing and the sensitivity of the P. vivax isolates to chloroquine and mefloquine was determined by Deli-test. FINDINGS Although five different allele sizes were amplified, the sequencing results showed that all of the isolates belonged to the VK210 variant. However, we observed substantial genetic diversity in the CRR, resulting in the identification of 10 different VK210 subtypes. The frequency of isolates that were resistant to chloroquine and mefloquine was 11.8 and 23.8%, respectively. However, we did not observe any difference in the frequency of the resistant isolates belonging to the VK210 subtypes. MAIN CONCLUSION The VK210 variant is the most frequently observed in the studied region and there is significant genetic variability in the CRR of the P. vivax CSP. Moreover, the antimalarial drug sensitivity profiles of the isolates does not seem to be related to the VK210 subtypes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36900/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLilainR_Riccio_etal_IOC_2019.pdfLilainR_Riccio_etal_IOC_2019.pdfapplication/pdf3741301https://www.arca.fiocruz.br/bitstream/icict/36900/2/LilainR_Riccio_etal_IOC_2019.pdf023e3ad34e0b32135430c08592365d4fMD52TEXTLilainR_Riccio_etal_IOC_2019.pdf.txtLilainR_Riccio_etal_IOC_2019.pdf.txtExtracted texttext/plain41711https://www.arca.fiocruz.br/bitstream/icict/36900/3/LilainR_Riccio_etal_IOC_2019.pdf.txt8fef2446d4c39792d8e263f004c77de6MD53icict/369002022-06-24 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dc.title.pt_BR.fl_str_mv |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon |
title |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon |
spellingShingle |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon Riccio, Lilian Rose Pratt Malária Palsmodium vivax Proteína circum-esporozoita Quimioresistência Malaria Palsmodium vivax Circumsporozoite protein Chemoresistance |
title_short |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon |
title_full |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon |
title_fullStr |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon |
title_full_unstemmed |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon |
title_sort |
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon |
author |
Riccio, Lilian Rose Pratt |
author_facet |
Riccio, Lilian Rose Pratt Baptista, Bárbara de Oliveira Torres, Vanessa Rodrigues Bianco Junior, Cesare Silva, Daiana de Souza Perce da Riccio, Evelyn Kety Pratt Lima Junior, Josué da Costa Totino, Paulo Renato Rivas Cassiano, Gustavo Capatti Melo, Luciane Moreno Storti Machado, Ricardo Luiz Dantas Ferreira, Joseli de Oliveira Banic, Dalma Maria Carvalho, Leonardo José de Moura Ribeiro, Cláudio Tadeu Daniel |
author_role |
author |
author2 |
Baptista, Bárbara de Oliveira Torres, Vanessa Rodrigues Bianco Junior, Cesare Silva, Daiana de Souza Perce da Riccio, Evelyn Kety Pratt Lima Junior, Josué da Costa Totino, Paulo Renato Rivas Cassiano, Gustavo Capatti Melo, Luciane Moreno Storti Machado, Ricardo Luiz Dantas Ferreira, Joseli de Oliveira Banic, Dalma Maria Carvalho, Leonardo José de Moura Ribeiro, Cláudio Tadeu Daniel |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Riccio, Lilian Rose Pratt Baptista, Bárbara de Oliveira Torres, Vanessa Rodrigues Bianco Junior, Cesare Silva, Daiana de Souza Perce da Riccio, Evelyn Kety Pratt Lima Junior, Josué da Costa Totino, Paulo Renato Rivas Cassiano, Gustavo Capatti Melo, Luciane Moreno Storti Machado, Ricardo Luiz Dantas Ferreira, Joseli de Oliveira Banic, Dalma Maria Carvalho, Leonardo José de Moura Ribeiro, Cláudio Tadeu Daniel |
dc.subject.other.pt_BR.fl_str_mv |
Malária Palsmodium vivax Proteína circum-esporozoita Quimioresistência |
topic |
Malária Palsmodium vivax Proteína circum-esporozoita Quimioresistência Malaria Palsmodium vivax Circumsporozoite protein Chemoresistance |
dc.subject.en.pt_BR.fl_str_mv |
Malaria Palsmodium vivax Circumsporozoite protein Chemoresistance |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-11-06T14:38:44Z |
dc.date.available.fl_str_mv |
2019-11-06T14:38:44Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RICCIO, Lilian Rose Prat et al. Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36900 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760190054 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
RICCIO, Lilian Rose Prat et al. Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019. 0074-0276 10.1590/0074-02760190054 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/36900 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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