Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.

Detalhes bibliográficos
Autor(a) principal: Seixas, Magda Oliveira
Data de Publicação: 2010
Outros Autores: Rocha, Larissa Carneiro, Carvalho, Mauricio Barreto, Menezes, Joelma Figueiredo, Lyra, Isa Menezes, Nascimento, Valma Maria Lopes do, Couto, Ricardo David, Atta, Ajax Mercês, Reis, Mitermayer Galvão dos, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7952
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
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spelling Seixas, Magda OliveiraRocha, Larissa CarneiroCarvalho, Mauricio BarretoMenezes, Joelma FigueiredoLyra, Isa MenezesNascimento, Valma Maria Lopes doCouto, Ricardo DavidAtta, Ajax MercêsReis, Mitermayer Galvão dosGonçalves, Marilda de Souza2014-07-14T18:35:39Z2014-07-14T18:35:39Z2010SEIXAS, M. O. et al. Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease. Lipids in Health and Disease, v. 9, p. 91, 2010.1476-511Xhttps://www.arca.fiocruz.br/handle/icict/795210.1186/1476-511X-9-91engBioMed CentralLevels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. 2Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação de Hematologia e Hemoterapia da Bahia. HEMOBA. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Pediátrico Professor Hosannah de Oliveira. Salvador, BA, BrasilFundação de Hematologia e Hemoterapia do Estado da Bahia. HEMOBA. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilBACKGROUND: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. METHODS: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. RESULTS: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005), bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001), aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol (P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of cholelithiasis. CONCLUSIONS: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesisAnemia Falciforme/sangueAnemia Falciforme/fisiopatologiaHDL-Colesterol/sangueDislipidemias/sangueAdolescenteAnemia Falciforme/complicaçõesMarcadores Biológicos/sangueBrasil/epidemiologiaCriançaColelitíase/complicaçõesColelitíase/epidemiologiaDislipidemias/epidemiologiaFemininoCardiopatias Congênitas/complicaçõesHemóliseMediadores da Inflamação/sangueHumanosLipídeos/sangueMasculinoRegistros MédicosPneumonia/complicaçõesPrevalênciaPrognósticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSeixas MG Levels of high-density....pdfSeixas MG Levels of high-density....pdfapplication/pdf368798https://www.arca.fiocruz.br/bitstream/icict/7952/1/Seixas%20MG%20Levels%20of%20high-density....pdffe97425b5a6ce0e38fe8618bf978954fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7952/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSeixas MG Levels of high-density....pdf.txtSeixas MG Levels of high-density....pdf.txtExtracted texttext/plain37875https://www.arca.fiocruz.br/bitstream/icict/7952/3/Seixas%20MG%20Levels%20of%20high-density....pdf.txtc988333bd161a9db970863d2a9b5f3c8MD53icict/79522023-03-15 14:33:05.118oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
title Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
spellingShingle Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
Seixas, Magda Oliveira
Anemia Falciforme/sangue
Anemia Falciforme/fisiopatologia
HDL-Colesterol/sangue
Dislipidemias/sangue
Adolescente
Anemia Falciforme/complicações
Marcadores Biológicos/sangue
Brasil/epidemiologia
Criança
Colelitíase/complicações
Colelitíase/epidemiologia
Dislipidemias/epidemiologia
Feminino
Cardiopatias Congênitas/complicações
Hemólise
Mediadores da Inflamação/sangue
Humanos
Lipídeos/sangue
Masculino
Registros Médicos
Pneumonia/complicações
Prevalência
Prognóstico
title_short Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
title_full Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
title_fullStr Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
title_full_unstemmed Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
title_sort Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.
author Seixas, Magda Oliveira
author_facet Seixas, Magda Oliveira
Rocha, Larissa Carneiro
Carvalho, Mauricio Barreto
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma Maria Lopes do
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author_role author
author2 Rocha, Larissa Carneiro
Carvalho, Mauricio Barreto
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma Maria Lopes do
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Seixas, Magda Oliveira
Rocha, Larissa Carneiro
Carvalho, Mauricio Barreto
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma Maria Lopes do
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
dc.subject.decs.pt_BR.fl_str_mv Anemia Falciforme/sangue
Anemia Falciforme/fisiopatologia
HDL-Colesterol/sangue
Dislipidemias/sangue
Adolescente
Anemia Falciforme/complicações
Marcadores Biológicos/sangue
Brasil/epidemiologia
Criança
Colelitíase/complicações
Colelitíase/epidemiologia
Dislipidemias/epidemiologia
Feminino
Cardiopatias Congênitas/complicações
Hemólise
Mediadores da Inflamação/sangue
Humanos
Lipídeos/sangue
Masculino
Registros Médicos
Pneumonia/complicações
Prevalência
Prognóstico
topic Anemia Falciforme/sangue
Anemia Falciforme/fisiopatologia
HDL-Colesterol/sangue
Dislipidemias/sangue
Adolescente
Anemia Falciforme/complicações
Marcadores Biológicos/sangue
Brasil/epidemiologia
Criança
Colelitíase/complicações
Colelitíase/epidemiologia
Dislipidemias/epidemiologia
Feminino
Cardiopatias Congênitas/complicações
Hemólise
Mediadores da Inflamação/sangue
Humanos
Lipídeos/sangue
Masculino
Registros Médicos
Pneumonia/complicações
Prevalência
Prognóstico
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-07-14T18:35:39Z
dc.date.available.fl_str_mv 2014-07-14T18:35:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SEIXAS, M. O. et al. Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease. Lipids in Health and Disease, v. 9, p. 91, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7952
dc.identifier.issn.none.fl_str_mv 1476-511X
dc.identifier.doi.none.fl_str_mv 10.1186/1476-511X-9-91
identifier_str_mv SEIXAS, M. O. et al. Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease. Lipids in Health and Disease, v. 9, p. 91, 2010.
1476-511X
10.1186/1476-511X-9-91
url https://www.arca.fiocruz.br/handle/icict/7952
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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