Impacto de la diabetes en la dinámica de la transmisíon de la tuberculosis en Argentina

• Autor(a) principal: Fernández, Hugo Roberto
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
• Texto Completo: https://www.arca.fiocruz.br/handle/icict/40239
• topic: Tuberculosis; Diabetes; Mathematical Models; Numerical Simulation; Intervention; Sensitivity Analysis; Modelos Matemáticos; Simulación Numérica; Declaraciones; Análisis de Sensibilidad; Tuberculosis; Diabetes; Diabetes Mellitus Tipo 2; Tuberculose; Modelos Matemáticos; Prevalência; Incidência; Estudos de Intervenção; Argentina

The link between Diabetes and Tuberculosis has been recognized for long time. In recent decades acquired epidemiological importance in light of the expansion of the epidemic of type 2 diabetes mellitus in TB-endemic settings. The coexistence of diabetes and tuberculosis could have serious implications on TB control in many developing countries and be the next challenge for the global control of tuberculosis. In this context a better understanding of the interaction between the two diseases will allow better tools to address their control. Mathematical models are tools that have played a key role in strategies for TB control and the establishment of intermediate targets for intervention programs. This work presents a model, which includes the main components of the dynamics of tuberculosis and evaluates the dynamics for diabetes to change this behavior, worsening the situation of tuberculosis. A deterministic population-based model is proposed to analyze the impact of diabetes on the dynamics and treatment of Tuberculosis. The model calibrated with data estimated by WHO TB allowed projecting various scenarios for Argentina, generated from the evidence of interaction between the two conditions and intervention measures. The results are consistent with the international literature as evidence of a negative impact of the increase in diabetes in the situation of tuberculosis and its control.