Ultrastructural study on experimental infection of rotavirus in a murine heterologous model

Detalhes bibliográficos
Autor(a) principal: Majerowicz, Selma
Data de Publicação: 1994
Outros Autores: Kubelka, Claire Fernandez, Stephens, Paulo, Barth, Ortrud Monika
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36740
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
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spelling Majerowicz, SelmaKubelka, Claire FernandezStephens, PauloBarth, Ortrud Monika2019-10-29T13:51:14Z2019-10-29T13:51:14Z1994MAJEROWICZ, Selma et al. Ultrastructural study on experimental infection of rotavirus in a murine heterologous model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 89, n. 3, p. 395-342, jul./set. 1994. Jul./Sept. 19940074-0276https://www.arca.fiocruz.br/handle/icict/3674010.1590/s0074-027619940003000181678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzRotavírus simianoModelo heterólogoUltraestruturaSimian rotavirusUltrastructureHeterologous modelUltrastructural study on experimental infection of rotavirus in a murine heterologous modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Viral replication, histopathological and ultrastructural changes were observed for a period of nine days in the small intestine of suckling mice infected with a simian rotavirus (SA11). Samples taken from duodenum, jejunum and ileum were prepared for light microscopy, transmission and scanning electron microscopy analysis. Histopathologic effect could be detected within 8 hr post-infection, when only a few altered cells were observed. Damage was extensive after 16 hr post-infection, showing swollen enterocytes and reduced and irregularly oriented microvilli at intestinal villi tips. Virus particles were detected at 16 and 48 hr post-infection, budding from the viroplasm into the rough endoplasmic reticulum cisternae in ileum enterocytes. Clear evidence of viral replication, observed by electron microscopy was not described before in heterologous murine models. Regeneration of the intestinal villi began at the third day post-infection. Despite some differences observed in clinical symptoms and microscopic analysis of homologous and heterologous rotavirus infections, we concluded that mechanisms of heterologous rotavirus infection in mice follow similar patterns to those observed in the homologous models.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36740/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOrtudBarth_ClaireKubelka_etal_IOC_1994.pdfOrtudBarth_ClaireKubelka_etal_IOC_1994.pdfapplication/pdf692149https://www.arca.fiocruz.br/bitstream/icict/36740/2/OrtudBarth_ClaireKubelka_etal_IOC_1994.pdf510d70591fbf0ea95be340d2ecdfa914MD52TEXTOrtudBarth_ClaireKubelka_etal_IOC_1994.pdf.txtOrtudBarth_ClaireKubelka_etal_IOC_1994.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
title Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
spellingShingle Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
Majerowicz, Selma
Rotavírus simiano
Modelo heterólogo
Ultraestrutura
Simian rotavirus
Ultrastructure
Heterologous model
title_short Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
title_full Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
title_fullStr Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
title_full_unstemmed Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
title_sort Ultrastructural study on experimental infection of rotavirus in a murine heterologous model
author Majerowicz, Selma
author_facet Majerowicz, Selma
Kubelka, Claire Fernandez
Stephens, Paulo
Barth, Ortrud Monika
author_role author
author2 Kubelka, Claire Fernandez
Stephens, Paulo
Barth, Ortrud Monika
author2_role author
author
author
dc.contributor.author.fl_str_mv Majerowicz, Selma
Kubelka, Claire Fernandez
Stephens, Paulo
Barth, Ortrud Monika
dc.subject.other.pt_BR.fl_str_mv Rotavírus simiano
Modelo heterólogo
Ultraestrutura
topic Rotavírus simiano
Modelo heterólogo
Ultraestrutura
Simian rotavirus
Ultrastructure
Heterologous model
dc.subject.en.pt_BR.fl_str_mv Simian rotavirus
Ultrastructure
Heterologous model
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2019-10-29T13:51:14Z
dc.date.available.fl_str_mv 2019-10-29T13:51:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAJEROWICZ, Selma et al. Ultrastructural study on experimental infection of rotavirus in a murine heterologous model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 89, n. 3, p. 395-342, jul./set. 1994. Jul./Sept. 1994
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36740
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02761994000300018
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MAJEROWICZ, Selma et al. Ultrastructural study on experimental infection of rotavirus in a murine heterologous model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 89, n. 3, p. 395-342, jul./set. 1994. Jul./Sept. 1994
0074-0276
10.1590/s0074-02761994000300018
1678-8060
url https://www.arca.fiocruz.br/handle/icict/36740
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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