High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/61161 |
Resumo: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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Moraes, Laise deSantos, Luciane AmorimArruda, Liã BárbaraSilva, Maria da Purificação Pereira daSilva, Márcio de OliveiraSilva, José Adriano GóesRamos, AndréSantos, Marcos Bastos dosTorres, Felipe GuimarãesOrge, CibeleTeixeira, Antonio Marcos dos SantosVieira, Thiago SantosRamírez, LauraSoto, ManuelGrassi, Maria Fernanda RiosSiqueira, Isadora Cristina deCosta, Dorcas LamounierCosta, Carlos Henrique NeryAndrade, Bruno de BezerrilAkrami, KevanOliveira, Camila Indiani deBoaventura, Viviane SampaioBarral Netto, ManoelBarral, AldinaVandamme, Anne-MiekeWeyenbergh, Johan VanKhouri, Ricardo2023-11-09T15:57:53Z2023-11-09T15:57:53Z2023MORAES, Laise de et al. High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil. Frontiers in Microbiology, v. 14, p. 1-14, 2023.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/6116110.3389/fmicb.2023.1221682Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Centre for Clinical Microbiology. Division of Infection & Immunity. University College London. London, United Kingdom.Secretaria de Saúde do Estado da Bahia. Centro Estadual Especializado em Diagnóstico, Assistência e Pesquisa. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Centro Estadual Especializado em Diagnóstico, Assistência e Pesquisa. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria de Saúde do Estado da Bahia. Centro Estadual Especializado em Diagnóstico, Assistência e Pesquisa. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Centro Estadual Especializado em Diagnóstico, Assistência e Pesquisa. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Departamento de Biología Molecular. Facultad de Ciencias. Centro de Biología Molecular Severo Ochoa. Consejo Superior de Investigaciones Científicas. Universidad Autónoma de Madrid. Madrid, Spain.Departamento de Biología Molecular. Facultad de Ciencias. Centro de Biología Molecular Severo Ochoa. Consejo Superior de Investigaciones Científicas. Universidad Autónoma de Madrid. Madrid, Spain.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, Brasil.Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital Santa Izabel. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Department of Microbiology. Immunology and Transplantation. Rega Institute for Medical Research. Clinical and Epidemiological Virology. Leuven, Belgium / Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Center for Global Health and Tropical Medicine. Lisbon, Portugal.Department of Microbiology. Immunology and Transplantation. Rega Institute for Medical Research. Clinical and Epidemiological Virology. Leuven, Belgium.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Microbiology. Immunology and Transplantation. Rega Institute for Medical Research. Clinical and Epidemiological Virology. Leuven, Belgium.Visceral leishmaniasis is an opportunistic disease in HIV-1 infected individuals, unrecognized as a determining factor for AIDS diagnosis. The growing geographical overlap of HIV-1 and Leishmania infections is an emerging challenge worldwide, as co-infection increases morbidity and mortality for both infections. Here, we determined the prevalence of people living with HIV (PWH) with a previous or ongoing infection by Leishmania infantum and investigated the virological and immunological factors associated with co-infection. We adopted a two-stage cross-sectional cohort (CSC) design (CSC-I, n = 5,346 and CSC-II, n = 317) of treatment-naïve HIV-1-infected individuals in Bahia, Brazil. In CSC-I, samples collected between 1998 and 2013 were used for serological screening for leishmaniasis by an in-house Enzyme-Linked Immunosorbent Assay (ELISA) with SLA (Soluble Leishmania infantum Antigen), resulting in a prevalence of previous or ongoing infection of 16.27%. Next, 317 PWH were prospectively recruited from July 2014 to December 2015 with the collection of sociodemographic and clinical data. Serological validation by two different immunoassays confirmed a prevalence of 15.46 and 8.20% by anti-SLA, and anti-HSP70 serology, respectively, whereas 4.73% were double-positive (DP). Stratification of these 317 individuals in DP and double-negative (DN) revealed a significant reduction of CD4+ counts and CD4+/CD8+ ratios and a tendency of increased viral load in the DP group, as compared to DN. No statistical differences in HIV-1 subtype distribution were observed between the two groups. However, we found a significant increase of CXCL10 (p = 0.0076) and a tendency of increased CXCL9 (p = 0.061) in individuals with DP serology, demonstrating intensified immune activation in this group. These findings were corroborated at the transcriptome level in independent Leishmania- and HIV-1-infected cohorts (Swiss HIV Cohort and Piaui Northeast Brazil Cohort), indicating that CXCL10 transcripts are shared by the IFN-dominated immune activation gene signatures of both pathogens and positively correlated to viral load in untreated PWH. This study demonstrated a high prevalence of PWH with L. infantum seropositivity in Bahia, Brazil, linked to IFN-mediated immune activation and a significant decrease in CD4+ levels. Our results highlight the urgent need to increase awareness and define public health strategies for the management and prevention of HIV-1 and L. infantum co-infection.engFrontiers MediaHIV-1Leishmania infantumLeishmaniose visceralAtivação imunológicaInteração hospedeiro-patógenoHIV-1Leishmania infantumVisceral leishmaniasisImmune activationHostpathogen interactionHIV-1Leishmania infantumLeishmaniose visceralHigh seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/61161/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMoraes, Laise de - High seroprevalence of Leishmania infantum is linked to immune activation in people with HIV....pdfMoraes, Laise de - High seroprevalence of Leishmania infantum is linked to immune activation in people with HIV....pdfapplication/pdf1192536https://www.arca.fiocruz.br/bitstream/icict/61161/2/Moraes%2c%20Laise%20de%20-%20High%20seroprevalence%20of%20Leishmania%20infantum%20is%20linked%20to%20immune%20activation%20in%20people%20with%20HIV....pdf0c3a6c5c3a60d7fcd7b5711a25961e96MD52icict/611612023-11-09 12:57:53.893oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-11-09T15:57:53Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil |
title |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil |
spellingShingle |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil Moraes, Laise de HIV-1 Leishmania infantum Leishmaniose visceral Ativação imunológica Interação hospedeiro-patógeno HIV-1 Leishmania infantum Visceral leishmaniasis Immune activation Hostpathogen interaction HIV-1 Leishmania infantum Leishmaniose visceral |
title_short |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil |
title_full |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil |
title_fullStr |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil |
title_full_unstemmed |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil |
title_sort |
High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil |
author |
Moraes, Laise de |
author_facet |
Moraes, Laise de Santos, Luciane Amorim Arruda, Liã Bárbara Silva, Maria da Purificação Pereira da Silva, Márcio de Oliveira Silva, José Adriano Góes Ramos, André Santos, Marcos Bastos dos Torres, Felipe Guimarães Orge, Cibele Teixeira, Antonio Marcos dos Santos Vieira, Thiago Santos Ramírez, Laura Soto, Manuel Grassi, Maria Fernanda Rios Siqueira, Isadora Cristina de Costa, Dorcas Lamounier Costa, Carlos Henrique Nery Andrade, Bruno de Bezerril Akrami, Kevan Oliveira, Camila Indiani de Boaventura, Viviane Sampaio Barral Netto, Manoel Barral, Aldina Vandamme, Anne-Mieke Weyenbergh, Johan Van Khouri, Ricardo |
author_role |
author |
author2 |
Santos, Luciane Amorim Arruda, Liã Bárbara Silva, Maria da Purificação Pereira da Silva, Márcio de Oliveira Silva, José Adriano Góes Ramos, André Santos, Marcos Bastos dos Torres, Felipe Guimarães Orge, Cibele Teixeira, Antonio Marcos dos Santos Vieira, Thiago Santos Ramírez, Laura Soto, Manuel Grassi, Maria Fernanda Rios Siqueira, Isadora Cristina de Costa, Dorcas Lamounier Costa, Carlos Henrique Nery Andrade, Bruno de Bezerril Akrami, Kevan Oliveira, Camila Indiani de Boaventura, Viviane Sampaio Barral Netto, Manoel Barral, Aldina Vandamme, Anne-Mieke Weyenbergh, Johan Van Khouri, Ricardo |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Moraes, Laise de Santos, Luciane Amorim Arruda, Liã Bárbara Silva, Maria da Purificação Pereira da Silva, Márcio de Oliveira Silva, José Adriano Góes Ramos, André Santos, Marcos Bastos dos Torres, Felipe Guimarães Orge, Cibele Teixeira, Antonio Marcos dos Santos Vieira, Thiago Santos Ramírez, Laura Soto, Manuel Grassi, Maria Fernanda Rios Siqueira, Isadora Cristina de Costa, Dorcas Lamounier Costa, Carlos Henrique Nery Andrade, Bruno de Bezerril Akrami, Kevan Oliveira, Camila Indiani de Boaventura, Viviane Sampaio Barral Netto, Manoel Barral, Aldina Vandamme, Anne-Mieke Weyenbergh, Johan Van Khouri, Ricardo |
dc.subject.other.en_US.fl_str_mv |
HIV-1 Leishmania infantum Leishmaniose visceral Ativação imunológica Interação hospedeiro-patógeno |
topic |
HIV-1 Leishmania infantum Leishmaniose visceral Ativação imunológica Interação hospedeiro-patógeno HIV-1 Leishmania infantum Visceral leishmaniasis Immune activation Hostpathogen interaction HIV-1 Leishmania infantum Leishmaniose visceral |
dc.subject.en.en_US.fl_str_mv |
HIV-1 Leishmania infantum Visceral leishmaniasis Immune activation Hostpathogen interaction |
dc.subject.decs.en_US.fl_str_mv |
HIV-1 Leishmania infantum Leishmaniose visceral |
description |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-11-09T15:57:53Z |
dc.date.available.fl_str_mv |
2023-11-09T15:57:53Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MORAES, Laise de et al. High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil. Frontiers in Microbiology, v. 14, p. 1-14, 2023. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/61161 |
dc.identifier.issn.en_US.fl_str_mv |
1664-302X |
dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2023.1221682 |
identifier_str_mv |
MORAES, Laise de et al. High seroprevalence of leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil. Frontiers in Microbiology, v. 14, p. 1-14, 2023. 1664-302X 10.3389/fmicb.2023.1221682 |
url |
https://www.arca.fiocruz.br/handle/icict/61161 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/61161/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/61161/2/Moraes%2c%20Laise%20de%20-%20High%20seroprevalence%20of%20Leishmania%20infantum%20is%20linked%20to%20immune%20activation%20in%20people%20with%20HIV....pdf |
bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 0c3a6c5c3a60d7fcd7b5711a25961e96 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
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1798324812203950080 |