Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7497 |
Resumo: | Universidade Federal da Bahia. Salvador, BA, Brasil |
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Bandeira, MaurícioSantos, Cleiton SilvaAzevedo, Everton Cruz deSoares, Luciane MarietaMacedo, Júlio OliveiraMarchi, SamyraSilva, Caroline Luane Rabelo daChagas Júnior, Adenizar Delgado dasMcBride, Alan John AlexanderMcBride, Flávia Weykamp da CruzReis, Mitermayer Galvão dosAthanazio, Daniel Abensur2014-04-04T18:55:38Z2014-04-04T18:55:38Z2011BANDEIRA, M. et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infection and Immunity, v. 79, n. 7, p. 2936–2940, 2011.1098-5522https://www.arca.fiocruz.br/handle/icict/749710.1128/IAI.05099-11engAmerican Society for MicrobiologyAttenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilThe aims of this study were to investigate the frequency of pulmonary hemorrhage (PH) in mice unable to produce functional B and T lymphocytes and to explore the effect of an inducible nitric oxide synthase gene (Inos) knockout (KO) on the frequency/severity of interstitial nephritis in vivo. We studied the outcome of infection by the virulent Leptospira interrogans serovar Copenhageni strain Cop. The animals used were Inos KO mice, recombination activating gene 1 (Rag1) KO mice, CB17 severe combined immunodeficiency (SCID) mice, and the respective wild-type (WT) C57BL/6 and BALB/c controls. The Inos KO and WT mice survived with no clinical symptoms of leptospirosis. The frequency and severity of nephritis was significantly lower in the Inos KO mice. All of the Rag1 KO and SCID animals died of acute leptospirosis, whereas all of the WT mice survived. PH was observed in 57 and 94% of Rag1 KO mice and in 83 and 100% of SCID mice, using inoculum doses of 107 and 106 leptospires, respectively. There was no evidence of PH in the WT controls. In conclusion, the loss of the Inos gene had a negligible effect on the outcome of leptospiral infection, although we observed a reduced susceptibility for interstitial nephritis in this group. Of note, the absence of functional B- and T-cell lymphocytes did not preclude the occurrence of PH. These data provide evidence that PH in leptospirosis may not be related only to autoimmune mechanisms.Genes RAG-1Hemorragia/imunologiaLeptospira interrogansLeptospirose/imunologiaPneumopatias/imunologiaNefrite Intersticial/imunologiaÓxido Nítrico Sintase Tipo II/genéticaAnimaisLinfócitos B/imunologiaLeptospirose/microbiologiaCamundongosCamundongos Endogâmicos BALB CCamundongos KnockoutÓxido Nítrico Sintase Tipo II/metabolismoLinfócitos T/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBandeira M. Attenuated Nephritis.pdfBandeira M. Attenuated Nephritis.pdfapplication/pdf519655https://www.arca.fiocruz.br/bitstream/icict/7497/1/Bandeira%20M.%20Attenuated%20Nephritis.pdf59e2e45aae2e4574fb5462f38c779546MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7497/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBandeira M. 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dc.title.pt_BR.fl_str_mv |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. |
title |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. |
spellingShingle |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Bandeira, Maurício Genes RAG-1 Hemorragia/imunologia Leptospira interrogans Leptospirose/imunologia Pneumopatias/imunologia Nefrite Intersticial/imunologia Óxido Nítrico Sintase Tipo II/genética Animais Linfócitos B/imunologia Leptospirose/microbiologia Camundongos Camundongos Endogâmicos BALB C Camundongos Knockout Óxido Nítrico Sintase Tipo II/metabolismo Linfócitos T/imunologia |
title_short |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. |
title_full |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. |
title_fullStr |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. |
title_full_unstemmed |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. |
title_sort |
Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. |
author |
Bandeira, Maurício |
author_facet |
Bandeira, Maurício Santos, Cleiton Silva Azevedo, Everton Cruz de Soares, Luciane Marieta Macedo, Júlio Oliveira Marchi, Samyra Silva, Caroline Luane Rabelo da Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flávia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
author_role |
author |
author2 |
Santos, Cleiton Silva Azevedo, Everton Cruz de Soares, Luciane Marieta Macedo, Júlio Oliveira Marchi, Samyra Silva, Caroline Luane Rabelo da Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flávia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bandeira, Maurício Santos, Cleiton Silva Azevedo, Everton Cruz de Soares, Luciane Marieta Macedo, Júlio Oliveira Marchi, Samyra Silva, Caroline Luane Rabelo da Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flávia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
dc.subject.decs.pt_BR.fl_str_mv |
Genes RAG-1 Hemorragia/imunologia Leptospira interrogans Leptospirose/imunologia Pneumopatias/imunologia Nefrite Intersticial/imunologia Óxido Nítrico Sintase Tipo II/genética Animais Linfócitos B/imunologia Leptospirose/microbiologia Camundongos Camundongos Endogâmicos BALB C Camundongos Knockout Óxido Nítrico Sintase Tipo II/metabolismo Linfócitos T/imunologia |
topic |
Genes RAG-1 Hemorragia/imunologia Leptospira interrogans Leptospirose/imunologia Pneumopatias/imunologia Nefrite Intersticial/imunologia Óxido Nítrico Sintase Tipo II/genética Animais Linfócitos B/imunologia Leptospirose/microbiologia Camundongos Camundongos Endogâmicos BALB C Camundongos Knockout Óxido Nítrico Sintase Tipo II/metabolismo Linfócitos T/imunologia |
description |
Universidade Federal da Bahia. Salvador, BA, Brasil |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2014-04-04T18:55:38Z |
dc.date.available.fl_str_mv |
2014-04-04T18:55:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BANDEIRA, M. et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infection and Immunity, v. 79, n. 7, p. 2936–2940, 2011. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7497 |
dc.identifier.issn.none.fl_str_mv |
1098-5522 |
dc.identifier.doi.none.fl_str_mv |
10.1128/IAI.05099-11 |
identifier_str_mv |
BANDEIRA, M. et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infection and Immunity, v. 79, n. 7, p. 2936–2940, 2011. 1098-5522 10.1128/IAI.05099-11 |
url |
https://www.arca.fiocruz.br/handle/icict/7497 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
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Repositório Institucional da FIOCRUZ (ARCA) |
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