Gap junctions and chagas disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | spa |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8986 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil |
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Adesse, Daniel PedraGoldenberg, Regina Coeli dos SantosFortes, Fabio da Silva de AzevedoJasminIacobas, Dumitru AndreiIacobas, SandaCarvalho, Antonio Carlos Campos deMeirelles, Maria de Nazareth Leal deHuang, HuanSoares, Milena Botelho PereiraTanowitz, Herbert BernardGarzoni, Luciana RibeiroSpray, David Conover2014-11-27T18:39:27Z2014-11-27T18:39:27Z2011ADESSE, D. P. et al. Gap junctions and chagas disease. Advances in Parasitology, v. 76, p. 63-81, 2011.0065-308Xhttps://www.arca.fiocruz.br/handle/icict/898610.1016/B978-0-12-385895-5.00003-7.spaElsevierGap junctions and chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilCentro Universitario Stadual da Zona Oeste. Colegiado de Ciencias Biologicas e da Saude (CCBS). Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USAAlbert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USAAlbert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USAUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USAFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilAlbert Einstein College of Medicine. Department of Pathology. Bronx, New York, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAlbert Einstein College of Medicine. Department of Pathology. Bronx, New York, USAFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilAlbert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NEW York, USAGap junction channels provide intercellular communication between cells. In the heart, these channels coordinate impulse propagation along the conduction system and through the contractile musculature, thereby providing synchronous and optimal cardiac output. As in other arrhythmogenic cardiac diseases, chagasic cardiomyopathy is associated with decreased expression of the gap junction protein connexin43 (Cx43) and its gene. Our studies of cardiac myocytes infected with Trypanosoma cruzi have revealed that synchronous contraction is greatly impaired and gap junction immunoreactivity is lost in infected cells. Such changes are not seen for molecules forming tight junctions, another component of the intercalated disc in cardiac myocytes. Transcriptomic studies of hearts from mouse models of Chagas disease and from acutely infected cardiac myocytes in vitro indicate profound remodelling of gene expression patterns involving heart rhythm determinant genes, suggesting underlying mechanisms of the functional pathology. One curious feature of the altered expression of Cx43 and its gene expression is that it is limited in both extent and location, suggesting that the more global deterioration in cardiac function may result in part from spread of damage signals from more seriously compromised cells to healthier ones.Cardiomiopatia Chagásica/parasitologiaJunções Gap/fisiologiaCoração/fisiologiaCoração/parasitologiaTrypanosoma cruzi/patogenicidadeAnimaisCélulas CultivadasPerfilação da Expressão GênicaInterações Hospedeiro-PatógenoHumanosCamundongosCélulas Musculares/parasitologiaCélulas Musculares/fisiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8986/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALAdesse D Gap junctions....pdfAdesse D Gap junctions....pdfapplication/pdf3813293https://www.arca.fiocruz.br/bitstream/icict/8986/2/Adesse%20D%20Gap%20junctions....pdf8f367abc71176dbf489ffbb82f276a47MD52TEXTAdesse D Gap junctions....pdf.txtAdesse D Gap junctions....pdf.txtExtracted texttext/plain49213https://www.arca.fiocruz.br/bitstream/icict/8986/3/Adesse%20D%20Gap%20junctions....pdf.txtcbf0adc3bd82009c8f45d38901550df7MD53icict/89862023-03-15 14:33:00.628oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Gap junctions and chagas disease |
| title |
Gap junctions and chagas disease |
| spellingShingle |
Gap junctions and chagas disease Adesse, Daniel Pedra Cardiomiopatia Chagásica/parasitologia Junções Gap/fisiologia Coração/fisiologia Coração/parasitologia Trypanosoma cruzi/patogenicidade Animais Células Cultivadas Perfilação da Expressão Gênica Interações Hospedeiro-Patógeno Humanos Camundongos Células Musculares/parasitologia Células Musculares/fisiologia |
| title_short |
Gap junctions and chagas disease |
| title_full |
Gap junctions and chagas disease |
| title_fullStr |
Gap junctions and chagas disease |
| title_full_unstemmed |
Gap junctions and chagas disease |
| title_sort |
Gap junctions and chagas disease |
| author |
Adesse, Daniel Pedra |
| author_facet |
Adesse, Daniel Pedra Goldenberg, Regina Coeli dos Santos Fortes, Fabio da Silva de Azevedo Jasmin Iacobas, Dumitru Andrei Iacobas, Sanda Carvalho, Antonio Carlos Campos de Meirelles, Maria de Nazareth Leal de Huang, Huan Soares, Milena Botelho Pereira Tanowitz, Herbert Bernard Garzoni, Luciana Ribeiro Spray, David Conover |
| author_role |
author |
| author2 |
Goldenberg, Regina Coeli dos Santos Fortes, Fabio da Silva de Azevedo Jasmin Iacobas, Dumitru Andrei Iacobas, Sanda Carvalho, Antonio Carlos Campos de Meirelles, Maria de Nazareth Leal de Huang, Huan Soares, Milena Botelho Pereira Tanowitz, Herbert Bernard Garzoni, Luciana Ribeiro Spray, David Conover |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Adesse, Daniel Pedra Goldenberg, Regina Coeli dos Santos Fortes, Fabio da Silva de Azevedo Jasmin Iacobas, Dumitru Andrei Iacobas, Sanda Carvalho, Antonio Carlos Campos de Meirelles, Maria de Nazareth Leal de Huang, Huan Soares, Milena Botelho Pereira Tanowitz, Herbert Bernard Garzoni, Luciana Ribeiro Spray, David Conover |
| dc.subject.decs.pt_BR.fl_str_mv |
Cardiomiopatia Chagásica/parasitologia Junções Gap/fisiologia Coração/fisiologia Coração/parasitologia Trypanosoma cruzi/patogenicidade Animais Células Cultivadas Perfilação da Expressão Gênica Interações Hospedeiro-Patógeno Humanos Camundongos Células Musculares/parasitologia Células Musculares/fisiologia |
| topic |
Cardiomiopatia Chagásica/parasitologia Junções Gap/fisiologia Coração/fisiologia Coração/parasitologia Trypanosoma cruzi/patogenicidade Animais Células Cultivadas Perfilação da Expressão Gênica Interações Hospedeiro-Patógeno Humanos Camundongos Células Musculares/parasitologia Células Musculares/fisiologia |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil |
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2011 |
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2011 |
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2014-11-27T18:39:27Z |
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2014-11-27T18:39:27Z |
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ADESSE, D. P. et al. Gap junctions and chagas disease. Advances in Parasitology, v. 76, p. 63-81, 2011. |
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https://www.arca.fiocruz.br/handle/icict/8986 |
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0065-308X |
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10.1016/B978-0-12-385895-5.00003-7. |
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ADESSE, D. P. et al. Gap junctions and chagas disease. Advances in Parasitology, v. 76, p. 63-81, 2011. 0065-308X 10.1016/B978-0-12-385895-5.00003-7. |
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