Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.

Detalhes bibliográficos
Autor(a) principal: Guimarães, Adriana Gibara
Data de Publicação: 2015
Outros Autores: Oliveira, Marlange Almeida, Alves, Rafael dos Santos, Menezes, Paula dos Passos, Serafini, Mairim Russo, Souza Araújo, Adriano Antunes de, Bezerra, Daniel Pereira, Quintans Júnior, Lucindo José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13431
Resumo: Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil
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spelling Guimarães, Adriana GibaraOliveira, Marlange AlmeidaAlves, Rafael dos SantosMenezes, Paula dos PassosSerafini, Mairim RussoSouza Araújo, Adriano Antunes deBezerra, Daniel PereiraQuintans Júnior, Lucindo José2016-03-31T19:14:21Z2016-03-31T19:14:21Z2015GUIMARÃES, A. G. et al. Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols. Chemico-Biological Interactions, v. 227, p. 69-76, 2015.0009-2797https://www.arca.fiocruz.br/handle/icict/13431dx.doi.org/10.1016/j.cbi.2014.12.020engElsevierEncapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Sergipe. Department of Health Education. Lagarto, SE, BrasilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, BrasilFederal University of Sergipe. Department of Health Education. Lagarto, SE, BrasilCancer pain is a major public health problem worldwide due to the strong impact on the quality of life of patients and side effects of the existing therapeutic options. Monoterpenes, as carvacrol (CARV), have been extensively studied about their therapeutic properties, especially their importance in the control of painful conditions and inflammation, which can be improved through the use of inclusion complexes of b-cyclodextrin (b-CD). We evaluated the effect of encapsulation of CARV in b-CD (CARV/b-CD) on the nociception induced by tumor cells (Sarcoma 180) in rodents. Inclusion complexes were prepared in two different procedures and characterized through thermal analysis and scanning electron microscopy. CARV/b-CD complex was administered (50 mg/kg, p.o.) in mice with tumor on the hind paw and was able to reduce the hyperalgesia (von Frey) during 24 h, unlike the free CARV (100 mg/kg, p.o.), which promoted effects until 9 h. Administration on alternate days of complex of CARV/b-CD (12.5–50 mg/kg, p.o.) reduced hyperalgesia, as well as spontaneous and palpation-induced nociception. However, pure CARV (50 mg/kg) did not cause significant changes in nociceptive responses. Together, these results produced evidence that the encapsulation of carvacrol in b-cyclodextrin can be useful for the development of new options for pain managementCancer painHyperalgesiaNociceptionMonoterpeneCarvacrolb-Cyclodextrininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13431/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGuimarães AG. Encapsulation of carvacrol....pdfGuimarães AG. Encapsulation of carvacrol....pdfapplication/pdf1280691https://www.arca.fiocruz.br/bitstream/icict/13431/2/Guimar%c3%a3es%20AG.%20Encapsulation%20of%20carvacrol....pdf1b25210e998e9c85c66ad6d7122682c9MD52TEXTGuimarães AG. Encapsulation of carvacrol....pdf.txtGuimarães AG. 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dc.title.pt_BR.fl_str_mv Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
spellingShingle Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
Guimarães, Adriana Gibara
Cancer pain
Hyperalgesia
Nociception
Monoterpene
Carvacrol
b-Cyclodextrin
title_short Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_full Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_fullStr Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_full_unstemmed Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_sort Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
author Guimarães, Adriana Gibara
author_facet Guimarães, Adriana Gibara
Oliveira, Marlange Almeida
Alves, Rafael dos Santos
Menezes, Paula dos Passos
Serafini, Mairim Russo
Souza Araújo, Adriano Antunes de
Bezerra, Daniel Pereira
Quintans Júnior, Lucindo José
author_role author
author2 Oliveira, Marlange Almeida
Alves, Rafael dos Santos
Menezes, Paula dos Passos
Serafini, Mairim Russo
Souza Araújo, Adriano Antunes de
Bezerra, Daniel Pereira
Quintans Júnior, Lucindo José
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Adriana Gibara
Oliveira, Marlange Almeida
Alves, Rafael dos Santos
Menezes, Paula dos Passos
Serafini, Mairim Russo
Souza Araújo, Adriano Antunes de
Bezerra, Daniel Pereira
Quintans Júnior, Lucindo José
dc.subject.en.pt_BR.fl_str_mv Cancer pain
Hyperalgesia
Nociception
Monoterpene
Carvacrol
b-Cyclodextrin
topic Cancer pain
Hyperalgesia
Nociception
Monoterpene
Carvacrol
b-Cyclodextrin
description Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-31T19:14:21Z
dc.date.available.fl_str_mv 2016-03-31T19:14:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUIMARÃES, A. G. et al. Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols. Chemico-Biological Interactions, v. 227, p. 69-76, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13431
dc.identifier.issn.none.fl_str_mv 0009-2797
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1016/j.cbi.2014.12.020
identifier_str_mv GUIMARÃES, A. G. et al. Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols. Chemico-Biological Interactions, v. 227, p. 69-76, 2015.
0009-2797
dx.doi.org/10.1016/j.cbi.2014.12.020
url https://www.arca.fiocruz.br/handle/icict/13431
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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