Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients

Detalhes bibliográficos
Autor(a) principal: Pacheco, Antonio G.
Data de Publicação: 2015
Outros Autores: Grinsztejn, Beatriz, Fonseca, Maria de Jesus M., Moreira, Ronaldo I., Veloso, Valdiléa G., Friedman, Ruth K., Santini-Oliveira, Marilia, Cardoso, Sandra W., Falcão, Melissa, Mill, José G., Bensenor, Isabela, Lotufo, Paulo, Chor, Dóra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29640
Resumo: Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
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spelling Pacheco, Antonio G.Grinsztejn, BeatrizFonseca, Maria de Jesus M.Moreira, Ronaldo I.Veloso, Valdiléa G.Friedman, Ruth K.Santini-Oliveira, MariliaCardoso, Sandra W.Falcão, MelissaMill, José G.Bensenor, IsabelaLotufo, PauloChor, Dóra2018-10-18T18:15:39Z2018-10-18T18:15:39Z2015PACHECO, Antonio G. et al. Traditional Risk Factors Are More Relevant than HIV-Specific Ones for Carotid Intima-Media Thickness (cIMT) in a Brazilian Cohort of HIV-Infected Patients. PLoS ONE, v. 10, n. 2, p. 1-10, Feb. 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/2964010.1371/journal.pone.0117461engTraditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Background: Combination antiretroviral therapy (cART) had a dramatic impact on the mortality profile in human immunodeficiency virus (HIV) infected individuals and increased their life-expectancy. Conditions associated with the aging process have been diagnosed more frequently among HIV-infected patients, particularly, cardiovascular diseases. Methods: Patients followed in the Instituto de Pesquisa Clínica Evandro Chagas (IPEC) prospective cohort in Rio de Janeiro were submitted to the general procedures from the Brazilian Longitudinal Study of Adult Health, comprising several anthropometric, laboratory and imaging data. Carotid intima-media thickness (cIMT) was measured by ultrasonography, following the Mannheim protocol. Linear regression and proportional odds models were used to compare groups and covariables in respect to cIMT. The best model was chosen with the adaptive lasso procedure. Results: A valid cIMT exam was available for 591 patients. Median cIMT was significantly larger for men than women (0.56mm vs. 0.53mm; p = 0.002; overall = 0.54mm). In univariable linear regression analysis, both traditional risk factors for cardiovascular diseases (CVD) and HIV-specific characteristics were significantly associated with cIMT values, but the best multivariable model chosen included only traditional characteristics. Hypertension presented the strongest association with higher cIMT terciles (OR = 2.51; 95%CI = 1.69-3.73), followed by current smoking (OR = 1,82; 95%CI = 1.19-2.79), family history of acute myocardial infarction or stroke (OR = 1.60; 95%CI = 1.10-2.32) and age (OR per year = 1.12; 95%CI = 1.10-1.14). Conclusions: Our results show that traditional cardiovascular disease (CVD) risk factors are the major players in determining increased cIMT among HIV infected patients in Brazil. This finding reinforces the need for thorough assessment of those risk factors in these patients to guarantee the incidence of CVD events remain under control.Combination antiretroviral therapy (cART)Human immunodeficiency virus (HIV)Carotid intima-media thickness (cIMT)HIV-Infected PatientsTraditional Risk Factorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/29640/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALTraditional risk factors are more relevant than HIV-specific ones_Beatriz_Grinstejn_etal_INI_Lapclin-AIDS_2015.pdfTraditional risk factors are more relevant than HIV-specific 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dc.title.pt_BR.fl_str_mv Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
title Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
spellingShingle Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
Pacheco, Antonio G.
Combination antiretroviral therapy (cART)
Human immunodeficiency virus (HIV)
Carotid intima-media thickness (cIMT)
HIV-Infected Patients
Traditional Risk Factors
title_short Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
title_full Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
title_fullStr Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
title_full_unstemmed Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
title_sort Traditional risk factors are more relevant than HIV-specific ones for carotid intima-media thickness (cIMT) in a Brazilian cohort of HIV-infected patients
author Pacheco, Antonio G.
author_facet Pacheco, Antonio G.
Grinsztejn, Beatriz
Fonseca, Maria de Jesus M.
Moreira, Ronaldo I.
Veloso, Valdiléa G.
Friedman, Ruth K.
Santini-Oliveira, Marilia
Cardoso, Sandra W.
Falcão, Melissa
Mill, José G.
Bensenor, Isabela
Lotufo, Paulo
Chor, Dóra
author_role author
author2 Grinsztejn, Beatriz
Fonseca, Maria de Jesus M.
Moreira, Ronaldo I.
Veloso, Valdiléa G.
Friedman, Ruth K.
Santini-Oliveira, Marilia
Cardoso, Sandra W.
Falcão, Melissa
Mill, José G.
Bensenor, Isabela
Lotufo, Paulo
Chor, Dóra
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pacheco, Antonio G.
Grinsztejn, Beatriz
Fonseca, Maria de Jesus M.
Moreira, Ronaldo I.
Veloso, Valdiléa G.
Friedman, Ruth K.
Santini-Oliveira, Marilia
Cardoso, Sandra W.
Falcão, Melissa
Mill, José G.
Bensenor, Isabela
Lotufo, Paulo
Chor, Dóra
dc.subject.en.none.fl_str_mv Combination antiretroviral therapy (cART)
Human immunodeficiency virus (HIV)
Carotid intima-media thickness (cIMT)
HIV-Infected Patients
Traditional Risk Factors
topic Combination antiretroviral therapy (cART)
Human immunodeficiency virus (HIV)
Carotid intima-media thickness (cIMT)
HIV-Infected Patients
Traditional Risk Factors
description Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2018-10-18T18:15:39Z
dc.date.available.fl_str_mv 2018-10-18T18:15:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv PACHECO, Antonio G. et al. Traditional Risk Factors Are More Relevant than HIV-Specific Ones for Carotid Intima-Media Thickness (cIMT) in a Brazilian Cohort of HIV-Infected Patients. PLoS ONE, v. 10, n. 2, p. 1-10, Feb. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29640
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0117461
identifier_str_mv PACHECO, Antonio G. et al. Traditional Risk Factors Are More Relevant than HIV-Specific Ones for Carotid Intima-Media Thickness (cIMT) in a Brazilian Cohort of HIV-Infected Patients. PLoS ONE, v. 10, n. 2, p. 1-10, Feb. 2015.
1932-6203
10.1371/journal.pone.0117461
url https://www.arca.fiocruz.br/handle/icict/29640
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/29640/1/license.txt
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