The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials

Detalhes bibliográficos
Autor(a) principal: Franca, Mônica
Data de Publicação: 2021
Outros Autores: Guimarães, Luiz H., Nascimento, Maurício T., Rocha, Paulo N., Carvalho, Lucas Pedreira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48665
Resumo: National Institutes of Health [AI136862.
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spelling Franca, MônicaGuimarães, Luiz H.Nascimento, Maurício T.Rocha, Paulo N.Carvalho, Lucas Pedreira de2021-08-19T12:41:46Z2021-08-19T12:41:46Z2021FRANCA, Mõnica et al. The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis is linked to disease progression but not to the therapeutic failure of pentavalent antimonials. Microbes and Infection, 2021.https://www.arca.fiocruz.br/handle/icict/48665National Institutes of Health [AI136862.Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal do Sul da Bahia. Teixeira de Freitas, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.High levels of pro-inflammatory cytokines in cutaneous leishmaniasis patients are associated with tissue damage and ulcer development. We found higher levels of TNF and IL-1in peripheral blood mononuclear cell supernatants in response to soluble Leishmania antigen in individuals with a longer duration of disease. In addition, L. braziliensis-infected patients with a longer disease progression before treatment presented a shorter time to cure after treatment onset. No associations were found between the levels of the pro-inflammatory cytokines IL-6, TNF and IL-1- and patients’ response to pentavalent antimony treatment. Our data suggest that while the Leishmania antigen-specific pro-inflammatory cytokines investigated may lead to ulcer development, they do not influence therapeutic failure in cutaneous leishmaniasis patients.engElsevierLeishmaniose cutâneaTerapêuticaCitocinasCutaneous leishmaniasisTherapeutic failureCytokinesThe Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonialsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48665/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALFranca, Monica The leishmania....pdfFranca, Monica The 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dc.title.pt_BR.fl_str_mv The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
title The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
spellingShingle The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
Franca, Mônica
Leishmaniose cutânea
Terapêutica
Citocinas
Cutaneous leishmaniasis
Therapeutic failure
Cytokines
title_short The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
title_full The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
title_fullStr The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
title_full_unstemmed The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
title_sort The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials
author Franca, Mônica
author_facet Franca, Mônica
Guimarães, Luiz H.
Nascimento, Maurício T.
Rocha, Paulo N.
Carvalho, Lucas Pedreira de
author_role author
author2 Guimarães, Luiz H.
Nascimento, Maurício T.
Rocha, Paulo N.
Carvalho, Lucas Pedreira de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Franca, Mônica
Guimarães, Luiz H.
Nascimento, Maurício T.
Rocha, Paulo N.
Carvalho, Lucas Pedreira de
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Terapêutica
Citocinas
topic Leishmaniose cutânea
Terapêutica
Citocinas
Cutaneous leishmaniasis
Therapeutic failure
Cytokines
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Therapeutic failure
Cytokines
description National Institutes of Health [AI136862.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-19T12:41:46Z
dc.date.available.fl_str_mv 2021-08-19T12:41:46Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FRANCA, Mõnica et al. The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis is linked to disease progression but not to the therapeutic failure of pentavalent antimonials. Microbes and Infection, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48665
identifier_str_mv FRANCA, Mõnica et al. The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis is linked to disease progression but not to the therapeutic failure of pentavalent antimonials. Microbes and Infection, 2021.
url https://www.arca.fiocruz.br/handle/icict/48665
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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