What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?

Detalhes bibliográficos
Autor(a) principal: Guterres, Alexandro
Data de Publicação: 2020
Outros Autores: Lima, Carlos Henrique de Azeredo, Miranda, Renan Lyra, Gadelha, Mônica Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41994
Resumo: Artigo encontra-se em acesso aberto por causa da pandemia mundial do COVID-19.
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spelling Guterres, AlexandroLima, Carlos Henrique de AzeredoMiranda, Renan LyraGadelha, Mônica Roberto2020-06-30T14:18:05Z2020-06-30T14:18:05Z2020GUTERRES, Alexandro et al. What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19? Infection, Genetics and Evolution, v. 85, 104417, p. 1-3, June 2020.1567-1348https://www.arca.fiocruz.br/handle/icict/4199410.1016/j.meegid.2020.1044171567-7257Artigo encontra-se em acesso aberto por causa da pandemia mundial do COVID-19.Instituto Estadual do Cérebro. Laboratório de Neuropatologia e Genética Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro. Laboratório de Neuropatologia e Genética Molecular. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro. Laboratório de Neuropatologia e Genética Molecular. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro. Laboratório de Neuropatologia e Genética Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Escola de Medicina. Centro de Pesquisa em Neuroendocrinologia. Divisão de Endocrinologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a pandemic associated with substantial morbidity and mortality. Despite of this, no vaccine or approved drug is available to eradicate the virus. In this manuscript, we present an alternative study area that may contribute to development of diagnostic biomarkers and therapeutic targets for COVID-19. We analyzed sixty SARS-CoV-2 genomes to identify regions that could work as virus-encoded miRNA seed sponges and potentially bind to human miRNA seed sites and prevent interaction with their native targets thereby relieving native miRNA suppression. MicroRNAs (miRNAs) are evolutionally conserved single-stranded RNAs that regulate gene expression at the posttranscriptional level by disrupting translation. MiRNAs are key players in variety of biological processes that regulate differentiation, development and activation of immune cells in both innate and adaptive immunity. We find 34 miRNAs for positive-sense viral RNA and 45 miRNAs for negative-sense that can strongly bind to certain key SARS-CoV-2 genes. The disruption and dysfunction of miRNAs may perturb the immune response and stimulate the release of inflammatory cytokines altering the cellular response to viral infection. Previous studies demonstrate that miRNAs have the potential to be used as diagnostic and therapeutic biomarkers. Therefore, its discovery and validation are essential for improving the diagnosis of infection and clinical monitoring in COVID-19.engElsevierSARS-CoV-2COVID-19microRNABiomarcadoresAlvos terapêuticosSARS-CoV-2COVID-19microRNABiomarkersTherapeutic targetsWhat is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
title What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
spellingShingle What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
Guterres, Alexandro
SARS-CoV-2
COVID-19
microRNA
Biomarcadores
Alvos terapêuticos
SARS-CoV-2
COVID-19
microRNA
Biomarkers
Therapeutic targets
title_short What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
title_full What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
title_fullStr What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
title_full_unstemmed What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
title_sort What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
author Guterres, Alexandro
author_facet Guterres, Alexandro
Lima, Carlos Henrique de Azeredo
Miranda, Renan Lyra
Gadelha, Mônica Roberto
author_role author
author2 Lima, Carlos Henrique de Azeredo
Miranda, Renan Lyra
Gadelha, Mônica Roberto
author2_role author
author
author
dc.contributor.author.fl_str_mv Guterres, Alexandro
Lima, Carlos Henrique de Azeredo
Miranda, Renan Lyra
Gadelha, Mônica Roberto
dc.subject.other.pt_BR.fl_str_mv SARS-CoV-2
COVID-19
microRNA
Biomarcadores
Alvos terapêuticos
topic SARS-CoV-2
COVID-19
microRNA
Biomarcadores
Alvos terapêuticos
SARS-CoV-2
COVID-19
microRNA
Biomarkers
Therapeutic targets
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
COVID-19
microRNA
Biomarkers
Therapeutic targets
description Artigo encontra-se em acesso aberto por causa da pandemia mundial do COVID-19.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-06-30T14:18:05Z
dc.date.available.fl_str_mv 2020-06-30T14:18:05Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUTERRES, Alexandro et al. What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19? Infection, Genetics and Evolution, v. 85, 104417, p. 1-3, June 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41994
dc.identifier.issn.pt_BR.fl_str_mv 1567-1348
dc.identifier.doi.none.fl_str_mv 10.1016/j.meegid.2020.104417
dc.identifier.eissn.none.fl_str_mv 1567-7257
identifier_str_mv GUTERRES, Alexandro et al. What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19? Infection, Genetics and Evolution, v. 85, 104417, p. 1-3, June 2020.
1567-1348
10.1016/j.meegid.2020.104417
1567-7257
url https://www.arca.fiocruz.br/handle/icict/41994
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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