Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species

Detalhes bibliográficos
Autor(a) principal: Santos-Oliveira, Joanna R.
Data de Publicação: 2011
Outros Autores: Da-Cruz, Alda M., Pires, Lucy H. S., Cupolillo, Elisa, Kuhls, Katrin, Giacoia-Gripp, Carmem B. W., Oliveira-Neto, Manoel P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36868
Resumo: 2020-11-05
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spelling Santos-Oliveira, Joanna R.Da-Cruz, Alda M.Pires, Lucy H. S.Cupolillo, ElisaKuhls, KatrinGiacoia-Gripp, Carmem B. W.Oliveira-Neto, Manoel P.2019-11-05T14:37:20Z2019-11-05T14:37:20Z2011SANTOS-OLIVEIRA, Joanna R. et al. Case report: atypical lesions as a sign of cutaneous dissemination of Visceral Leishmaniasis in a Human Immunodeficiency Virus-positive patient simultaneously infected by two viscerotropic Leishmania species. American Journal of Tropical Medicine and Hygiene, v. 85, n. 1, p. 55-59, 2011.0002-9637https://www.arca.fiocruz.br/handle/icict/3686810.4269/ajtmh.2011.10-03981476-1645engAmerican Society of Tropical Medicine and HygieneCase report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania speciesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-05Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Secretaria Municipal de Saúde de Cabo Frio. Cabo Frio, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Charité University Medicine Berlin. Institute of Microbiology and Hygiene. Berlin, Germany.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Leishmaniasis is considered an emerging opportunistic disease in human immunodeficiency virus (HIV)– infected patients who have considerably variable clinical presentation. We report a patient with visceral leishmaniasis who had unexpected clinical aspects (atypical cutaneous lesions appearing after long-term evidence of visceral parasites). The patient had hepatoesplenomegaly in the absence of fever, but was otherwise generally healthy. The HIV viral load was low despite severe immunossupression (low lymphocyte proliferation and low level of interferon-γ, concomitant with a high lymphocyte activation status). Surprisingly, two Leishmania strains were isolated from his bone marrow (typical L. infantum sequence MON-1, type A) and skin (L. donovani MON-2 sequence); this second strain had not been previously identified in Brazil. The association of visceral leishmaniasis and HIV/acquired immunodeficiency syndrome is a largely unknown disease, particularly in areas in which leishmaniasis is not endemic. Such atypical cases indicate that this disease can be undiagnosed in clinical settings.Visceral leishmaniasisAtypical lesionsHuman Immunodeficiency VirusViscerotropic Leishmania speciesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36868/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Santos-Oliveira_Joanna_etal_INI_2011.pdfve_Santos-Oliveira_Joanna_etal_INI_2011.pdfapplication/pdf870822https://www.arca.fiocruz.br/bitstream/icict/36868/2/ve_Santos-Oliveira_Joanna_etal_INI_2011.pdf884f76d424ff3e71173dfb9c0ee6ed7eMD52TEXTve_Santos-Oliveira_Joanna_etal_INI_2011.pdf.txtve_Santos-Oliveira_Joanna_etal_INI_2011.pdf.txtExtracted texttext/plain27473https://www.arca.fiocruz.br/bitstream/icict/36868/3/ve_Santos-Oliveira_Joanna_etal_INI_2011.pdf.txt6c101936914aa34e67c649cc286439d3MD53icict/368682023-09-05 10:26:14.486oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:26:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
title Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
spellingShingle Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
Santos-Oliveira, Joanna R.
Visceral leishmaniasis
Atypical lesions
Human Immunodeficiency Virus
Viscerotropic Leishmania species
title_short Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
title_full Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
title_fullStr Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
title_full_unstemmed Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
title_sort Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species
author Santos-Oliveira, Joanna R.
author_facet Santos-Oliveira, Joanna R.
Da-Cruz, Alda M.
Pires, Lucy H. S.
Cupolillo, Elisa
Kuhls, Katrin
Giacoia-Gripp, Carmem B. W.
Oliveira-Neto, Manoel P.
author_role author
author2 Da-Cruz, Alda M.
Pires, Lucy H. S.
Cupolillo, Elisa
Kuhls, Katrin
Giacoia-Gripp, Carmem B. W.
Oliveira-Neto, Manoel P.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos-Oliveira, Joanna R.
Da-Cruz, Alda M.
Pires, Lucy H. S.
Cupolillo, Elisa
Kuhls, Katrin
Giacoia-Gripp, Carmem B. W.
Oliveira-Neto, Manoel P.
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Atypical lesions
Human Immunodeficiency Virus
Viscerotropic Leishmania species
topic Visceral leishmaniasis
Atypical lesions
Human Immunodeficiency Virus
Viscerotropic Leishmania species
description 2020-11-05
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-11-05T14:37:20Z
dc.date.available.fl_str_mv 2019-11-05T14:37:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS-OLIVEIRA, Joanna R. et al. Case report: atypical lesions as a sign of cutaneous dissemination of Visceral Leishmaniasis in a Human Immunodeficiency Virus-positive patient simultaneously infected by two viscerotropic Leishmania species. American Journal of Tropical Medicine and Hygiene, v. 85, n. 1, p. 55-59, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36868
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
dc.identifier.doi.none.fl_str_mv 10.4269/ajtmh.2011.10-0398
dc.identifier.eissn.none.fl_str_mv 1476-1645
identifier_str_mv SANTOS-OLIVEIRA, Joanna R. et al. Case report: atypical lesions as a sign of cutaneous dissemination of Visceral Leishmaniasis in a Human Immunodeficiency Virus-positive patient simultaneously infected by two viscerotropic Leishmania species. American Journal of Tropical Medicine and Hygiene, v. 85, n. 1, p. 55-59, 2011.
0002-9637
10.4269/ajtmh.2011.10-0398
1476-1645
url https://www.arca.fiocruz.br/handle/icict/36868
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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