Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15205 |
Resumo: | CNPq, FAPESB and CAPES |
| id |
CRUZ_99dd8df83ebb8f77754591167a4a662c |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/15205 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Campos, Keina MacieleTeixeira, Tatiane OliveiraLima, Ana Tereza CerqueiraCosta, Ryan SantosCarneiro, Tamires Cana BrasilSilva, Darizy FláviaBarreto, Maurício LimaPontes-de-Carvalho, Lain CarlosAlcantara, Neuza Maria NevesFigueiredo, Camila Alexandrina2016-08-09T13:38:25Z2016-08-09T13:38:25Z2014CAMPOS, K. M. et al. Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties. Journal of Pharmacy and Pharmacology, v. 2, p. 38-49, 2014.0022-3573https://www.arca.fiocruz.br/handle/icict/15205CNPq, FAPESB and CAPESUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilEugenol, an aromatic product, exhibits anti-inflammatory properties, however, little is known about its effect in allergic inflammation mediated by Th2-type cells and cytokines. We examined the pharmacological potential of this compound in a murine model of respiratory allergy to Bt (Blomia tropicalis). For this, AJ mice were sensitized (100 μg/animal s.c.) and challenged (10 μg/animal i.n.) with Bt mite extract. Sensitized animals were treated or not with eugenol (20, 40 or 80 mg/kg) and the following parameters were analyzed: number of total cells in BAL (bronchoalveolar lavage); EPO (eosinophil peroxidase activity) and histopathological changes in the lungs; serum level of specific IgE, IgG1 and IgG2a and; concentration of Th2 cytokines on BAL and spleen cultures. In addition, the capability of eugenol in relaxing tracheal smooth muscle was also evaluated. Our results showed that treatment with eugenol significantly reduced the airway inflammation, decreasing the cellular infiltrate, EPO and mucus in the lungs, as well as the production of Th2 cytokines. It was also demonstrated a dilator effect of eugenol observed by the relaxation of normal and hyper-reactivity isolated trachea upon carbachol stimulation. These results suggest that eugenol has potential as an anti-asthmatic drug by both bronchodilator and immunomodulatory properties.eng0022-3573Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Propertiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAsthmaBlomia tropicalisNatural productsEugenolinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15205/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMaciele CK Antiasthmatic....pdfMaciele CK Antiasthmatic....pdfapplication/pdf704319https://www.arca.fiocruz.br/bitstream/icict/15205/2/Maciele%20CK%20Antiasthmatic....pdf896f9d4b29d73ed2252be02400f181beMD52TEXTMaciele CK Antiasthmatic....pdf.txtMaciele CK Antiasthmatic....pdf.txtExtracted texttext/plain40523https://www.arca.fiocruz.br/bitstream/icict/15205/3/Maciele%20CK%20Antiasthmatic....pdf.txt08e576d858c01c959d6f8f6c011b1b54MD53icict/152052023-03-15 14:33:59.134oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties |
| title |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties |
| spellingShingle |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties Campos, Keina Maciele Asthma Blomia tropicalis Natural products Eugenol |
| title_short |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties |
| title_full |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties |
| title_fullStr |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties |
| title_full_unstemmed |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties |
| title_sort |
Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties |
| author |
Campos, Keina Maciele |
| author_facet |
Campos, Keina Maciele Teixeira, Tatiane Oliveira Lima, Ana Tereza Cerqueira Costa, Ryan Santos Carneiro, Tamires Cana Brasil Silva, Darizy Flávia Barreto, Maurício Lima Pontes-de-Carvalho, Lain Carlos Alcantara, Neuza Maria Neves Figueiredo, Camila Alexandrina |
| author_role |
author |
| author2 |
Teixeira, Tatiane Oliveira Lima, Ana Tereza Cerqueira Costa, Ryan Santos Carneiro, Tamires Cana Brasil Silva, Darizy Flávia Barreto, Maurício Lima Pontes-de-Carvalho, Lain Carlos Alcantara, Neuza Maria Neves Figueiredo, Camila Alexandrina |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Campos, Keina Maciele Teixeira, Tatiane Oliveira Lima, Ana Tereza Cerqueira Costa, Ryan Santos Carneiro, Tamires Cana Brasil Silva, Darizy Flávia Barreto, Maurício Lima Pontes-de-Carvalho, Lain Carlos Alcantara, Neuza Maria Neves Figueiredo, Camila Alexandrina |
| dc.subject.en.pt_BR.fl_str_mv |
Asthma Blomia tropicalis Natural products Eugenol |
| topic |
Asthma Blomia tropicalis Natural products Eugenol |
| description |
CNPq, FAPESB and CAPES |
| publishDate |
2014 |
| dc.date.issued.fl_str_mv |
2014 |
| dc.date.accessioned.fl_str_mv |
2016-08-09T13:38:25Z |
| dc.date.available.fl_str_mv |
2016-08-09T13:38:25Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
CAMPOS, K. M. et al. Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties. Journal of Pharmacy and Pharmacology, v. 2, p. 38-49, 2014. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15205 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0022-3573 |
| identifier_str_mv |
CAMPOS, K. M. et al. Antiasthmatic Effect of Eugenol (4-Allyl-2-Methoxyophenol) Mediated by Both Bronchodilator and Immunomodulatory Properties. Journal of Pharmacy and Pharmacology, v. 2, p. 38-49, 2014. 0022-3573 |
| url |
https://www.arca.fiocruz.br/handle/icict/15205 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
0022-3573 |
| publisher.none.fl_str_mv |
0022-3573 |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/15205/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/15205/2/Maciele%20CK%20Antiasthmatic....pdf https://www.arca.fiocruz.br/bitstream/icict/15205/3/Maciele%20CK%20Antiasthmatic....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 896f9d4b29d73ed2252be02400f181be 08e576d858c01c959d6f8f6c011b1b54 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008855004610560 |