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spelling David, Bruna AraujoRezende, Rafael MachadoAntunes, Maísa MotaSantos, Mônica MoraisLopes, Maria Alice FreitasDiniz, Ariane BarrosPereira, Rafaela Vaz SousaMarchesi, Sarah CozzerAlvarenga, Débora MoreiraNakagaki, Brenda NaemiAraújo, Alan MoreiraReis, Daniela Silva dosRocha, Renata MontiMarques, Pedro EliasLee, Woo-YongDeniset, JustinLiew, Pei XiongRubino, StephenCox, LauraPinho, VanessaCunha, Thiago MattarFernandes, Gabriel RochaOliveira, André GustavoTeixeira, Mauro MartinsKubes, PaulMenezes, Gustavo Batista2017-12-06T18:43:34Z2017-12-06T18:43:34Z2016DAVID, Bruna Araujo et al. Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. Gastroenterology. v. 151, n. 6, p. 1176-1191, 20160016-5085https://www.arca.fiocruz.br/handle/icict/2353110.1053/j.gastro.2016.08.024engElsevier Inc.CyTOFDCCyTOFDCLiver DevelopmentMouse ModelCombination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-01Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilHarvard Medical School, Brigham and Women’s Hospital. Ann Romney Center for Neurologic Diseases. Boston, MA, United States of America.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversity of Calgary. Alberta, CanadaUniversity of Calgary. Alberta, CanadaUniversity of Calgary. Alberta, CanadaHarvard Medical School, Brigham and Women’s Hospital. Ann Romney Center for Neurologic Diseases. Boston, MA, United States of America.Harvard Medical School, Brigham and Women’s Hospital. Ann Romney Center for Neurologic Diseases. Boston, MA, United States of America.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Resolução de Inflamação. Belo Horizonte, MG, BrazilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversity of Calgary. Alberta, CanadaUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilBACKGROUND & AIMS: Resident macrophages are derived from yolk sac precursors and seed the liver during embryogenesis. Native cells may be replaced by bone marrow precursors during extensive injuries, irradiation, and infections. We investigated the liver populations of myeloid immune cells and their location, as well as the dynamics of phagocyte repopulation after full depletion. The effects on liver function due to the substitution of original phagocytes by bone marrow-derived surrogates were also examined. METHODS: We collected and analyzed liver tissues from C57BL/6 (control), LysM-EGFP, B6 ACTb-EGFP, CCR2-/-, CD11c-EYFP, CD11c-EYFP-DTR, germ-free mice, CX3CR1gfp/gfp, CX3CR1gpf/wt, and CX3CR1-DTR-EYFP. Liver nonparenchymal cells were immunophenotyped using mass cytometry and gene expression analyses. Kupffer and dendritic cells were depleted from mice by administration of clodronate, and their location and phenotype were examined using intravital microscopy and time-of-flight mass cytometry. Mice were given acetaminophen gavage or intravenous injections of fluorescently labeled Escherichia coli, blood samples were collected and analyzed, and liver function was evaluated. We assessed cytokine profiles of liver tissues using a multiplexed array. RESULTS: Using mass cytometry and gene expression analyses, we identified 2 populations of hepatic macrophages and 2 populations of monocytes. We also identified 4 populations of dendritic cells and 1 population of basophils. After selective depletion of liver phagocytes, intravascular myeloid precursors began to differentiate into macrophages and dendritic cells; dendritic cells migrated out of sinusoids, after a delay, via the chemokine CX3CL1. The cell distribution returned to normal in 2 weeks, but the repopulated livers were unable to fully respond to drug-induced injury or clear bacteria for at least 1 month. This defect was associated with increased levels of inflammatory cytokines, and dexamethasone accelerated the repopulation of liver phagocytes. CONCLUSIONS: In studies of hepatic phagocyte depletion in mice, we found that myeloid precursors can differentiate into liver macrophages and dendritic cells, which each localize to distinct tissue compartments. 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dc.title.pt_BR.fl_str_mv Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
title Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
spellingShingle Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
David, Bruna Araujo
CyTOF
DC
CyTOF
DC
Liver Development
Mouse Model
title_short Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
title_full Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
title_fullStr Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
title_full_unstemmed Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
title_sort Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
author David, Bruna Araujo
author_facet David, Bruna Araujo
Rezende, Rafael Machado
Antunes, Maísa Mota
Santos, Mônica Morais
Lopes, Maria Alice Freitas
Diniz, Ariane Barros
Pereira, Rafaela Vaz Sousa
Marchesi, Sarah Cozzer
Alvarenga, Débora Moreira
Nakagaki, Brenda Naemi
Araújo, Alan Moreira
Reis, Daniela Silva dos
Rocha, Renata Monti
Marques, Pedro Elias
Lee, Woo-Yong
Deniset, Justin
Liew, Pei Xiong
Rubino, Stephen
Cox, Laura
Pinho, Vanessa
Cunha, Thiago Mattar
Fernandes, Gabriel Rocha
Oliveira, André Gustavo
Teixeira, Mauro Martins
Kubes, Paul
Menezes, Gustavo Batista
author_role author
author2 Rezende, Rafael Machado
Antunes, Maísa Mota
Santos, Mônica Morais
Lopes, Maria Alice Freitas
Diniz, Ariane Barros
Pereira, Rafaela Vaz Sousa
Marchesi, Sarah Cozzer
Alvarenga, Débora Moreira
Nakagaki, Brenda Naemi
Araújo, Alan Moreira
Reis, Daniela Silva dos
Rocha, Renata Monti
Marques, Pedro Elias
Lee, Woo-Yong
Deniset, Justin
Liew, Pei Xiong
Rubino, Stephen
Cox, Laura
Pinho, Vanessa
Cunha, Thiago Mattar
Fernandes, Gabriel Rocha
Oliveira, André Gustavo
Teixeira, Mauro Martins
Kubes, Paul
Menezes, Gustavo Batista
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv David, Bruna Araujo
Rezende, Rafael Machado
Antunes, Maísa Mota
Santos, Mônica Morais
Lopes, Maria Alice Freitas
Diniz, Ariane Barros
Pereira, Rafaela Vaz Sousa
Marchesi, Sarah Cozzer
Alvarenga, Débora Moreira
Nakagaki, Brenda Naemi
Araújo, Alan Moreira
Reis, Daniela Silva dos
Rocha, Renata Monti
Marques, Pedro Elias
Lee, Woo-Yong
Deniset, Justin
Liew, Pei Xiong
Rubino, Stephen
Cox, Laura
Pinho, Vanessa
Cunha, Thiago Mattar
Fernandes, Gabriel Rocha
Oliveira, André Gustavo
Teixeira, Mauro Martins
Kubes, Paul
Menezes, Gustavo Batista
dc.subject.other.pt_BR.fl_str_mv CyTOF
DC
topic CyTOF
DC
CyTOF
DC
Liver Development
Mouse Model
dc.subject.en.pt_BR.fl_str_mv CyTOF
DC
Liver Development
Mouse Model
description 2021-01-01
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-12-06T18:43:34Z
dc.date.available.fl_str_mv 2017-12-06T18:43:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DAVID, Bruna Araujo et al. Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. Gastroenterology. v. 151, n. 6, p. 1176-1191, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23531
dc.identifier.issn.pt_BR.fl_str_mv 0016-5085
dc.identifier.doi.none.fl_str_mv 10.1053/j.gastro.2016.08.024
identifier_str_mv DAVID, Bruna Araujo et al. Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. Gastroenterology. v. 151, n. 6, p. 1176-1191, 2016
0016-5085
10.1053/j.gastro.2016.08.024
url https://www.arca.fiocruz.br/handle/icict/23531
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Inc.
publisher.none.fl_str_mv Elsevier Inc.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/23531/1/license.txt
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