In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker

Detalhes bibliográficos
Autor(a) principal: Colares, Aracélio Viana
Data de Publicação: 2013
Outros Autores: Souza, Fernando Almeida, Taniwaki, Noemi Nosomi, Souza, Celeste da Silva Freitas, Costa, José GalbertoMartins da, Calabrese, Kátia da Silva, Silva, Ana Lúcia Abreu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11799
Resumo: Universidade Federal do Maranhão (UFMA). Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil / Faculdade Leão Sampaio (FALS). Juazeiro do Norte, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
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spelling Colares, Aracélio VianaSouza, Fernando AlmeidaTaniwaki, Noemi NosomiSouza, Celeste da Silva FreitasCosta, José GalbertoMartins daCalabrese, Kátia da SilvaSilva, Ana Lúcia Abreu2015-09-21T17:25:53Z2015-09-21T17:25:53Z2013COLARES, Aracélio Viana; et al. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker. Evidence-Based Complementary and Alternative Medicine. v.2013, Article ID 727042, 7p, 2013.1741-4288https://www.arca.fiocruz.br/handle/icict/1179910.1155/2013/727042engHindawi Publishing CorporationIn Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Bakerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão (UFMA). Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil / Faculdade Leão Sampaio (FALS). Juazeiro do Norte, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Instituto Adolf Lutz (IAL). Unidade de Microscopia Eletrônica. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Regional do Cariri (URCA). Laboratório de Pesquisa de Produtos Naturais. Crato, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Maranhão (UEMA). Departamento de Patologia. São Luis, MA, Brasil.The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients. Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent discontinuation of treatment. In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea (VAEO) and its major compound -bisabolol against Leishmania amazonensis. The essential oil and -bisabolol showed activity against promastigotes (IC50 7.35 and 4.95 g/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 g/mL, resp.). Neither product showed any cytotoxicity on treated macrophages. The ultrastructural analysis of promastigotes incubated with VAEO or -bisabolol at 30 g/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions.The results give evidence that both VAEO and -bisabolol have potential as new therapeutic agents against leishmaniasis.Vanillosmopsis arboreaAsteraceaeIn VitroAntileishmanial ActivityLeishmanioseAsteraceaeTécnicas In Vitroinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11799/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALceleste_souza_etal_ioc_2013.pdfapplication/pdf2538717https://www.arca.fiocruz.br/bitstream/icict/11799/2/celeste_souza_etal_ioc_2013.pdf10c6b8e27c6bc44cf5cb03139b79a331MD52TEXTceleste_souza_etal_ioc_2013.pdf.txtceleste_souza_etal_ioc_2013.pdf.txtExtracted texttext/plain34923https://www.arca.fiocruz.br/bitstream/icict/11799/3/celeste_souza_etal_ioc_2013.pdf.txtd463ac4bbd5c029d320884ace65bffd9MD53icict/117992022-06-24 13:02:49.168oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:02:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
title In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
spellingShingle In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
Colares, Aracélio Viana
Vanillosmopsis arborea
Asteraceae
In Vitro
Antileishmanial Activity
Leishmaniose
Asteraceae
Técnicas In Vitro
title_short In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
title_full In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
title_fullStr In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
title_full_unstemmed In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
title_sort In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
author Colares, Aracélio Viana
author_facet Colares, Aracélio Viana
Souza, Fernando Almeida
Taniwaki, Noemi Nosomi
Souza, Celeste da Silva Freitas
Costa, José GalbertoMartins da
Calabrese, Kátia da Silva
Silva, Ana Lúcia Abreu
author_role author
author2 Souza, Fernando Almeida
Taniwaki, Noemi Nosomi
Souza, Celeste da Silva Freitas
Costa, José GalbertoMartins da
Calabrese, Kátia da Silva
Silva, Ana Lúcia Abreu
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Colares, Aracélio Viana
Souza, Fernando Almeida
Taniwaki, Noemi Nosomi
Souza, Celeste da Silva Freitas
Costa, José GalbertoMartins da
Calabrese, Kátia da Silva
Silva, Ana Lúcia Abreu
dc.subject.en.pt_BR.fl_str_mv Vanillosmopsis arborea
Asteraceae
In Vitro
Antileishmanial Activity
topic Vanillosmopsis arborea
Asteraceae
In Vitro
Antileishmanial Activity
Leishmaniose
Asteraceae
Técnicas In Vitro
dc.subject.decs.pt_BR.fl_str_mv Leishmaniose
Asteraceae
Técnicas In Vitro
description Universidade Federal do Maranhão (UFMA). Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil / Faculdade Leão Sampaio (FALS). Juazeiro do Norte, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-09-21T17:25:53Z
dc.date.available.fl_str_mv 2015-09-21T17:25:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COLARES, Aracélio Viana; et al. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker. Evidence-Based Complementary and Alternative Medicine. v.2013, Article ID 727042, 7p, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11799
dc.identifier.issn.pt_BR.fl_str_mv 1741-4288
dc.identifier.doi.pt_BR.fl_str_mv 10.1155/2013/727042
identifier_str_mv COLARES, Aracélio Viana; et al. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker. Evidence-Based Complementary and Alternative Medicine. v.2013, Article ID 727042, 7p, 2013.
1741-4288
10.1155/2013/727042
url https://www.arca.fiocruz.br/handle/icict/11799
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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