Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56406 |
Resumo: | Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil / Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Herlev, Denmark. |
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Kaagaard, Molly D.Wegener, AlmaGomes, Laura C.Holm, Anna E.Lima, Karine O.Matos, Luan O.Vieira, Isabelle V. M.Souza, Rodrigo Medeiros deVestergaard, Lasse S.Marinho, Claudio Romero FariasSantos, Flávia Barreto dosBiering-Sørensen, TorSilvestre, Odilson M.Brainin, Philip2023-01-09T18:23:36Z2023-01-09T18:23:36Z2022KAAGAARD, Molly D. et al. Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature. Plos One, v. 17, n. 11, e0276725, p. 1 - 22, Nov. 2022.1932-6203https://www.arca.fiocruz.br/handle/icict/5640610.1371/ journal.pone.0276725engPublic Library of SciencePapel potencial da transtorácica ecocardiografiaTriagem sistólica do VE disfunção em pacientes com história de infecção por dengue.Corte transversal e estudo de coorteRevisão da literaturaPotential role of transthoracic echocardiographyCross-sectional and cohort studyDysfunction in patients with a history of dengue infectionReview of the literaturePotential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literatureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil / Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Herlev, Denmark.Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil / Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Herlev, Denmark.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil / Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Herlev, Denmark.Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil.Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil.Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil.Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil.National Malaria Reference Laboratory, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Herlev, Denmark / Faculty of Biomedical Sciences, Copenhagen University, Copenhagen, Denmark.Universidade Federal do Acre. Centro de Ciência Saúde e Esporte. Rio Branco, Acre, Brasil.Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil / Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Herlev, Denmark.Background Dengue virus can affect the cardiovascular system and men may be at higher risk of severe complications than women. We hypothesized that clinical dengue virus (DENV) infection could induce myocardial alterations of the left ventricle (LV) and that these changes could be detected by transthoracic echocardiography. Methodology/Principal findings We examined individuals from Acre in the Amazon Basin of Brazil in 2020 as part of the Malaria Heart Study. By questionnaires we collected information on self-reported prior dengue infection. All individuals underwent transthoracic echocardiography, analysis of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). We included 521 persons (mean age 40±15 years, 39% men, 50% urban areas) of which 253 (49%) had a history of dengue infection. In multivariable models adjusted for clinical and sociodemographic data, a history of self-reported dengue was significantly associated with lower LVEF (β = -2.37, P < 0.01) and lower GLS (β = 1.08, P < 0.01) in men, whereas no significant associations were found in women (P > 0.05). In line with these findings, men with a history of dengue had higher rates of LV systolic dysfunction (LVEF < 50% = 20%; GLS < 16% = 17%) than those without a history of dengue (LVEF < 50% = 7%; GLS < 16% = 8%; P < 0.01 and 0.06, respectively). Conclusions/Significance The findings of this study suggest that a clinical infection by dengue virus could induce myocardial alterations, mainly in men and in the LV, which could be detected by conventional transthoracic echocardiography. Hence, these results highlight a potential role of echocardiography for screening LV dysfunction in participants with a history of dengue infection. Further larger studies are warranted to validate the findings of this study.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56406/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFlaviaBSantos_etal_IOC_2022.pdfFlaviaBSantos_etal_IOC_2022.pdfapplication/pdf1539222https://www.arca.fiocruz.br/bitstream/icict/56406/2/FlaviaBSantos_etal_IOC_2022.pdf52fc85b2e8ab14ba5fc814390d25b0bbMD52icict/564062023-09-04 11:10:47.971oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:10:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature |
| title |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature |
| spellingShingle |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature Kaagaard, Molly D. Papel potencial da transtorácica ecocardiografia Triagem sistólica do VE disfunção em pacientes com história de infecção por dengue. Corte transversal e estudo de coorte Revisão da literatura Potential role of transthoracic echocardiography Cross-sectional and cohort study Dysfunction in patients with a history of dengue infection Review of the literature |
| title_short |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature |
| title_full |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature |
| title_fullStr |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature |
| title_full_unstemmed |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature |
| title_sort |
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature |
| author |
Kaagaard, Molly D. |
| author_facet |
Kaagaard, Molly D. Wegener, Alma Gomes, Laura C. Holm, Anna E. Lima, Karine O. Matos, Luan O. Vieira, Isabelle V. M. Souza, Rodrigo Medeiros de Vestergaard, Lasse S. Marinho, Claudio Romero Farias Santos, Flávia Barreto dos Biering-Sørensen, Tor Silvestre, Odilson M. Brainin, Philip |
| author_role |
author |
| author2 |
Wegener, Alma Gomes, Laura C. Holm, Anna E. Lima, Karine O. Matos, Luan O. Vieira, Isabelle V. M. Souza, Rodrigo Medeiros de Vestergaard, Lasse S. Marinho, Claudio Romero Farias Santos, Flávia Barreto dos Biering-Sørensen, Tor Silvestre, Odilson M. Brainin, Philip |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Kaagaard, Molly D. Wegener, Alma Gomes, Laura C. Holm, Anna E. Lima, Karine O. Matos, Luan O. Vieira, Isabelle V. M. Souza, Rodrigo Medeiros de Vestergaard, Lasse S. Marinho, Claudio Romero Farias Santos, Flávia Barreto dos Biering-Sørensen, Tor Silvestre, Odilson M. Brainin, Philip |
| dc.subject.other.en_US.fl_str_mv |
Papel potencial da transtorácica ecocardiografia Triagem sistólica do VE disfunção em pacientes com história de infecção por dengue. Corte transversal e estudo de coorte Revisão da literatura |
| topic |
Papel potencial da transtorácica ecocardiografia Triagem sistólica do VE disfunção em pacientes com história de infecção por dengue. Corte transversal e estudo de coorte Revisão da literatura Potential role of transthoracic echocardiography Cross-sectional and cohort study Dysfunction in patients with a history of dengue infection Review of the literature |
| dc.subject.en.en_US.fl_str_mv |
Potential role of transthoracic echocardiography Cross-sectional and cohort study Dysfunction in patients with a history of dengue infection Review of the literature |
| description |
Universidade Federal do Acre.Centro Multidisciplinário. Cruzeiro do Sul, Acre, Brasil / Department of Cardiology, Copenhagen University Hospital–Herlev and Gentofte, Herlev, Denmark. |
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2022 |
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2022 |
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2023-01-09T18:23:36Z |
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2023-01-09T18:23:36Z |
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KAAGAARD, Molly D. et al. Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature. Plos One, v. 17, n. 11, e0276725, p. 1 - 22, Nov. 2022. |
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1932-6203 |
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10.1371/ journal.pone.0276725 |
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KAAGAARD, Molly D. et al. Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature. Plos One, v. 17, n. 11, e0276725, p. 1 - 22, Nov. 2022. 1932-6203 10.1371/ journal.pone.0276725 |
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