The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises

Detalhes bibliográficos
Autor(a) principal: Freire, Ivna Vidal
Data de Publicação: 2014
Outros Autores: Machado, Marco, Ribeiro, Ícaro José Santos, Hackney, Anthony C, Barbosa, Ana Angélica Leal, Pereira, Rafael
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8158
Resumo: State University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, Brasil
id CRUZ_a6f81c8b6c98c1f4c4aa3be0ccd64c92
oai_identifier_str oai:www.arca.fiocruz.br:icict/8158
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Freire, Ivna VidalMachado, MarcoRibeiro, Ícaro José SantosHackney, Anthony CBarbosa, Ana Angélica LealPereira, Rafael2014-08-08T19:24:28Z2014-08-08T19:24:28Z2014FREIRE, I. V. et al. The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises. Journal of the Renin-Angiotensin-Aldosterone System, 2014.1470-3203,https://www.arca.fiocruz.br/handle/icict/815810.1177/1470320314540733engSage PublicationsThe D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercisesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleState University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, BrasilUniversitary Fundation of Itaperuna. Laboratory of Human Movement Studies. Itaperuna, RJ, Brasil / Universidade Iguaçu Itaperuna. Laboratory of Physiology and Biokinetics. Itaperuna, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity of North Carolina. Endocrine Section. Applied Physiology Laboratory. Chapel Hill, USAState University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, BrasilState University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, BrasilHypothesis/introduction: The association of ACE I/D polymorphism and hemodynamic response to exercise have been limited to primarily aerobic exercises. We hypothesized that D allele carriers would show greater hemodynamic response to resistance exercise, as has been observed with aerobic. This study aimed to investigate the association of ACE I/D polymorphism and hemodynamic (blood pressure (BP), heart rate (HR) and rate-pressure product (RPP)) response to resistance exercise in young healthy subjects. Materials and methods: ACE I/D polymorphisms were studied by PCR analysis from 75 healthy men. Subjects completed a resistance exercise session of three sets of 10 knee extension repetitions with loads of 50, 75 and 100% of 10RM and two-minute rest intervals. Hemodynamic measures were recorded before and immediately after each set. Analysis of variance was used to identify significant differences among ACE genotypes. Results: ACE I/D polymorphism is associated with hemodynamic response to resistance exercise, as healthy subjects with ACE D allele were prone to higher responses. In addition, this phenotypic difference seems to be a load-dependent trend. Conclusion: ACE DD carriers exhibit greater heart work during resistance exercise. Future studies should focus on the influence of resistance training period with different workloads on the hemodynamic response in healthy individuals with different ACE genotypes.Renin-angiotensin systemCandidate geneACE I/D polymorphismExerciseBlood pressureinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFreire IV The D allele....pdfFreire IV The D allele....pdfapplication/pdf856583https://www.arca.fiocruz.br/bitstream/icict/8158/1/Freire%20IV%20The%20D%20allele....pdf0381d9dd6603a77ff21a805c56877e44MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8158/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFreire IV The D allele....pdf.txtFreire IV The D allele....pdf.txtExtracted texttext/plain38228https://www.arca.fiocruz.br/bitstream/icict/8158/3/Freire%20IV%20The%20D%20allele....pdf.txte6379a6b7f815100548efedcfdff5fa6MD53icict/81582023-03-15 14:33:56.409oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
title The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
spellingShingle The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
Freire, Ivna Vidal
Renin-angiotensin system
Candidate gene
ACE I/D polymorphism
Exercise
Blood pressure
title_short The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
title_full The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
title_fullStr The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
title_full_unstemmed The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
title_sort The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
author Freire, Ivna Vidal
author_facet Freire, Ivna Vidal
Machado, Marco
Ribeiro, Ícaro José Santos
Hackney, Anthony C
Barbosa, Ana Angélica Leal
Pereira, Rafael
author_role author
author2 Machado, Marco
Ribeiro, Ícaro José Santos
Hackney, Anthony C
Barbosa, Ana Angélica Leal
Pereira, Rafael
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Freire, Ivna Vidal
Machado, Marco
Ribeiro, Ícaro José Santos
Hackney, Anthony C
Barbosa, Ana Angélica Leal
Pereira, Rafael
dc.subject.en.pt_BR.fl_str_mv Renin-angiotensin system
Candidate gene
ACE I/D polymorphism
Exercise
Blood pressure
topic Renin-angiotensin system
Candidate gene
ACE I/D polymorphism
Exercise
Blood pressure
description State University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, Brasil
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-08-08T19:24:28Z
dc.date.available.fl_str_mv 2014-08-08T19:24:28Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREIRE, I. V. et al. The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises. Journal of the Renin-Angiotensin-Aldosterone System, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8158
dc.identifier.issn.none.fl_str_mv 1470-3203,
dc.identifier.doi.none.fl_str_mv 10.1177/1470320314540733
identifier_str_mv FREIRE, I. V. et al. The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises. Journal of the Renin-Angiotensin-Aldosterone System, 2014.
1470-3203,
10.1177/1470320314540733
url https://www.arca.fiocruz.br/handle/icict/8158
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/8158/1/Freire%20IV%20The%20D%20allele....pdf
https://www.arca.fiocruz.br/bitstream/icict/8158/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/8158/3/Freire%20IV%20The%20D%20allele....pdf.txt
bitstream.checksum.fl_str_mv 0381d9dd6603a77ff21a805c56877e44
7d48279ffeed55da8dfe2f8e81f3b81f
e6379a6b7f815100548efedcfdff5fa6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324683937939456

Registros relacionados