Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection

Detalhes bibliográficos
Autor(a) principal: Spagnolello, Ornella
Data de Publicação: 2021
Outros Autores: Pinacchio, Claudia, Santinell, Letizia, Vassalini, Paolo, Innocenti, Giuseppe Pietro, Girolamo, Gabriella De, Fabris, Silvia, Giovanetti, Marta, Angeletti, Silvia, Russo, Alessandro, Mastroianni, Claudio M., Ciccozzi, Massimo, Ceccarelli, Giancarlo, d’Ettorre, Gabriella
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51422
Resumo: Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.
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spelling Spagnolello, OrnellaPinacchio, ClaudiaSantinell, LetiziaVassalini, PaoloInnocenti, Giuseppe PietroGirolamo, Gabriella DeFabris, SilviaGiovanetti, MartaAngeletti, SilviaRusso, AlessandroMastroianni, Claudio M.Ciccozzi, MassimoCeccarelli, Giancarlod’Ettorre, Gabriella2022-02-23T11:04:21Z2022-02-23T11:04:21Z2021SPAGNOLELLO, Ornella et al. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9, Mar. 2021.0009-3157https://www.arca.fiocruz.br/handle/icict/5142210.1159/000515344engKargerCOVID-19DisbioseEixo intestino-pulmãoProbióticosTempestade Sistêmica de CitocinasMicrobiomaSARS-CoV-2DysbiosisCOVID-19Gut-lung axisProbioticsSystemic cytokine stormSARS-CoV-2Targeting MicrobiomeTargeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Medical Statistic and Molecular Epidemiology Unit. University of Biomedical Campus, Rome, Italy.Medical Statistic and Molecular Epidemiology Unit. University of Biomedical Campus, Rome, Italy / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas, Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Unit of Clinical Laboratory Science, University of Biomedical Campus. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Medical Statistic and Molecular Epidemiology Unit. University of Biomedical Campus, Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy / Migrant and Global Health Research Organization (Mi-HeRo), Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host’s microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response (“gutlung axis”). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to prevent and treat COVID-19 infection must be considered on top of the limited evidence-based therapy currently available. Addressing intestinal dysbiosis with a probiotic supplement may, therefore, be a sensible option to be evaluated, in addition to current best available medical treatments. Herein, we summed up pathophysiologic assumptions and current evidence regarding bacteriotherapy administration in preventing and treating COVID-19 pneumonia.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51422/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOrnellaSpagnolelo_MartaGiovenetti_etal_IOC_2021..pdfOrnellaSpagnolelo_MartaGiovenetti_etal_IOC_2021..pdfapplication/pdf375824https://www.arca.fiocruz.br/bitstream/icict/51422/2/OrnellaSpagnolelo_MartaGiovenetti_etal_IOC_2021..pdf96823297672f0c884152a3af3ae93161MD52icict/514222023-09-05 10:15:33.185oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:15:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
title Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
spellingShingle Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
Spagnolello, Ornella
COVID-19
Disbiose
Eixo intestino-pulmão
Probióticos
Tempestade Sistêmica de Citocinas
Microbioma
SARS-CoV-2
Dysbiosis
COVID-19
Gut-lung axis
Probiotics
Systemic cytokine storm
SARS-CoV-2
Targeting Microbiome
title_short Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
title_full Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
title_fullStr Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
title_full_unstemmed Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
title_sort Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
author Spagnolello, Ornella
author_facet Spagnolello, Ornella
Pinacchio, Claudia
Santinell, Letizia
Vassalini, Paolo
Innocenti, Giuseppe Pietro
Girolamo, Gabriella De
Fabris, Silvia
Giovanetti, Marta
Angeletti, Silvia
Russo, Alessandro
Mastroianni, Claudio M.
Ciccozzi, Massimo
Ceccarelli, Giancarlo
d’Ettorre, Gabriella
author_role author
author2 Pinacchio, Claudia
Santinell, Letizia
Vassalini, Paolo
Innocenti, Giuseppe Pietro
Girolamo, Gabriella De
Fabris, Silvia
Giovanetti, Marta
Angeletti, Silvia
Russo, Alessandro
Mastroianni, Claudio M.
Ciccozzi, Massimo
Ceccarelli, Giancarlo
d’Ettorre, Gabriella
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Spagnolello, Ornella
Pinacchio, Claudia
Santinell, Letizia
Vassalini, Paolo
Innocenti, Giuseppe Pietro
Girolamo, Gabriella De
Fabris, Silvia
Giovanetti, Marta
Angeletti, Silvia
Russo, Alessandro
Mastroianni, Claudio M.
Ciccozzi, Massimo
Ceccarelli, Giancarlo
d’Ettorre, Gabriella
dc.subject.other.pt_BR.fl_str_mv COVID-19
Disbiose
Eixo intestino-pulmão
Probióticos
Tempestade Sistêmica de Citocinas
Microbioma
SARS-CoV-2
topic COVID-19
Disbiose
Eixo intestino-pulmão
Probióticos
Tempestade Sistêmica de Citocinas
Microbioma
SARS-CoV-2
Dysbiosis
COVID-19
Gut-lung axis
Probiotics
Systemic cytokine storm
SARS-CoV-2
Targeting Microbiome
dc.subject.en.pt_BR.fl_str_mv Dysbiosis
COVID-19
Gut-lung axis
Probiotics
Systemic cytokine storm
SARS-CoV-2
Targeting Microbiome
description Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-23T11:04:21Z
dc.date.available.fl_str_mv 2022-02-23T11:04:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SPAGNOLELLO, Ornella et al. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9, Mar. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51422
dc.identifier.issn.pt_BR.fl_str_mv 0009-3157
dc.identifier.doi.none.fl_str_mv 10.1159/000515344
identifier_str_mv SPAGNOLELLO, Ornella et al. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9, Mar. 2021.
0009-3157
10.1159/000515344
url https://www.arca.fiocruz.br/handle/icict/51422
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51422/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51422/2/OrnellaSpagnolelo_MartaGiovenetti_etal_IOC_2021..pdf
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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