Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51422 |
Resumo: | Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy. |
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Spagnolello, OrnellaPinacchio, ClaudiaSantinell, LetiziaVassalini, PaoloInnocenti, Giuseppe PietroGirolamo, Gabriella DeFabris, SilviaGiovanetti, MartaAngeletti, SilviaRusso, AlessandroMastroianni, Claudio M.Ciccozzi, MassimoCeccarelli, Giancarlod’Ettorre, Gabriella2022-02-23T11:04:21Z2022-02-23T11:04:21Z2021SPAGNOLELLO, Ornella et al. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9, Mar. 2021.0009-3157https://www.arca.fiocruz.br/handle/icict/5142210.1159/000515344engKargerCOVID-19DisbioseEixo intestino-pulmãoProbióticosTempestade Sistêmica de CitocinasMicrobiomaSARS-CoV-2DysbiosisCOVID-19Gut-lung axisProbioticsSystemic cytokine stormSARS-CoV-2Targeting MicrobiomeTargeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Medical Statistic and Molecular Epidemiology Unit. University of Biomedical Campus, Rome, Italy.Medical Statistic and Molecular Epidemiology Unit. University of Biomedical Campus, Rome, Italy / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas, Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Unit of Clinical Laboratory Science, University of Biomedical Campus. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Medical Statistic and Molecular Epidemiology Unit. University of Biomedical Campus, Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy / Migrant and Global Health Research Organization (Mi-HeRo), Rome, Italy.Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy / COVID-19 Unit, Azienda Policlinico “Umberto I” University Hospital. Rome, Italy.Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host’s microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response (“gutlung axis”). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to prevent and treat COVID-19 infection must be considered on top of the limited evidence-based therapy currently available. Addressing intestinal dysbiosis with a probiotic supplement may, therefore, be a sensible option to be evaluated, in addition to current best available medical treatments. Herein, we summed up pathophysiologic assumptions and current evidence regarding bacteriotherapy administration in preventing and treating COVID-19 pneumonia.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51422/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOrnellaSpagnolelo_MartaGiovenetti_etal_IOC_2021..pdfOrnellaSpagnolelo_MartaGiovenetti_etal_IOC_2021..pdfapplication/pdf375824https://www.arca.fiocruz.br/bitstream/icict/51422/2/OrnellaSpagnolelo_MartaGiovenetti_etal_IOC_2021..pdf96823297672f0c884152a3af3ae93161MD52icict/514222023-09-05 10:15:33.185oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:15:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection |
title |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection |
spellingShingle |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection Spagnolello, Ornella COVID-19 Disbiose Eixo intestino-pulmão Probióticos Tempestade Sistêmica de Citocinas Microbioma SARS-CoV-2 Dysbiosis COVID-19 Gut-lung axis Probiotics Systemic cytokine storm SARS-CoV-2 Targeting Microbiome |
title_short |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection |
title_full |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection |
title_fullStr |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection |
title_full_unstemmed |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection |
title_sort |
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection |
author |
Spagnolello, Ornella |
author_facet |
Spagnolello, Ornella Pinacchio, Claudia Santinell, Letizia Vassalini, Paolo Innocenti, Giuseppe Pietro Girolamo, Gabriella De Fabris, Silvia Giovanetti, Marta Angeletti, Silvia Russo, Alessandro Mastroianni, Claudio M. Ciccozzi, Massimo Ceccarelli, Giancarlo d’Ettorre, Gabriella |
author_role |
author |
author2 |
Pinacchio, Claudia Santinell, Letizia Vassalini, Paolo Innocenti, Giuseppe Pietro Girolamo, Gabriella De Fabris, Silvia Giovanetti, Marta Angeletti, Silvia Russo, Alessandro Mastroianni, Claudio M. Ciccozzi, Massimo Ceccarelli, Giancarlo d’Ettorre, Gabriella |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Spagnolello, Ornella Pinacchio, Claudia Santinell, Letizia Vassalini, Paolo Innocenti, Giuseppe Pietro Girolamo, Gabriella De Fabris, Silvia Giovanetti, Marta Angeletti, Silvia Russo, Alessandro Mastroianni, Claudio M. Ciccozzi, Massimo Ceccarelli, Giancarlo d’Ettorre, Gabriella |
dc.subject.other.pt_BR.fl_str_mv |
COVID-19 Disbiose Eixo intestino-pulmão Probióticos Tempestade Sistêmica de Citocinas Microbioma SARS-CoV-2 |
topic |
COVID-19 Disbiose Eixo intestino-pulmão Probióticos Tempestade Sistêmica de Citocinas Microbioma SARS-CoV-2 Dysbiosis COVID-19 Gut-lung axis Probiotics Systemic cytokine storm SARS-CoV-2 Targeting Microbiome |
dc.subject.en.pt_BR.fl_str_mv |
Dysbiosis COVID-19 Gut-lung axis Probiotics Systemic cytokine storm SARS-CoV-2 Targeting Microbiome |
description |
Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-02-23T11:04:21Z |
dc.date.available.fl_str_mv |
2022-02-23T11:04:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
SPAGNOLELLO, Ornella et al. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9, Mar. 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/51422 |
dc.identifier.issn.pt_BR.fl_str_mv |
0009-3157 |
dc.identifier.doi.none.fl_str_mv |
10.1159/000515344 |
identifier_str_mv |
SPAGNOLELLO, Ornella et al. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9, Mar. 2021. 0009-3157 10.1159/000515344 |
url |
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Karger |
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