T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44579 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Bittar, Rita C.Nogueira, Ricardo S.Gonçalves, Ricardo VieiraRibeiro, Vanessa PinhoMattos, Marise S.Oliveira Neto, Manoel PaesCoutinho, Sergio G.Cruz, Alda M. da2020-11-22T19:58:36Z2020-11-22T19:58:36Z2007BITTAR, Rita C. et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 5, p. 625-630, Aug. 2007.0074-0276https://www.arca.fiocruz.br/handle/icict/4457910.1590/S0074-027620070050000691678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Leishmania (Viannia) braziliensisInfecção assintomáticaLeishmaniose curadaCitocinasSubconjuntos de células TImunidade a longo prazoAsymptomatic infectionLeishmania (Viannia) braziliensisCured leishmaniasisCytokinesT-cell subsetsLong term immunityT-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Subclinical or asymptomatic infection is documented in individuals living in endemic areas for leishmaniasis suggesting that the development of an appropriate immune response can control parasite replication and maintain tissue integrity. A low morbidity indicates that intrinsic factors could favor resistance to Leishmania infection. Herein, leishmanial T-cell responses induced in subjects with low susceptibility to leishmaniasis as asymptomatic subjects were compared to those observed in cured cutaneous leishmaniasis (CCL) patients, who controlled the disease after antimonial therapy. All of them have shown maintenance of specific long-term immune responses characterized by expansion of higher proportions of CD4+ as compared to CD8+ Leishmania reactive T-lymphocytes. Asymptomatic subjects had lower indexes of in vitro Leishmania induced lymphoproliferative responses and interferon-gamma (IFN-γ) production in comparison to CCL patients. On the other hand, interleukin (IL-10) production was much higher in asymptomatics than in CCL, while no differences in IL-5 levels were found. In conclusion, long lived T-cell responses achieved by asymptomatic individuals differed from those who had developed symptomatic leishmaniasis in terms of intensity of lymphocyte activation (proliferation or IFN-γ) and regulatory mechanisms (IL-10). The absence of the disease in asymptomatics could be explained by their intrinsic ability to create a balance between immunoregulatory (IL-10) and effector cytokines (IFN-γ), leading to parasite destruction without producing skin tissue damage. The establishment of profiles of cell-mediated immune responses associated with resistance against Leishmania infection is likely to make new inroads into understanding the long-lived immune protection against the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44579/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRitaCBittar_AldaMCruz_etal_IOC_2007.pdfRitaCBittar_AldaMCruz_etal_IOC_2007.pdfapplication/pdf159465https://www.arca.fiocruz.br/bitstream/icict/44579/2/RitaCBittar_AldaMCruz_etal_IOC_2007.pdfcd44419e0b6bd74334608505a7763fb5MD52TEXTRitaCBittar_AldaMCruz_etal_IOC_2007.pdf.txtRitaCBittar_AldaMCruz_etal_IOC_2007.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis |
title |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis |
spellingShingle |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis Bittar, Rita C. Leishmania (Viannia) braziliensis Infecção assintomática Leishmaniose curada Citocinas Subconjuntos de células T Imunidade a longo prazo Asymptomatic infection Leishmania (Viannia) braziliensis Cured leishmaniasis Cytokines T-cell subsets Long term immunity |
title_short |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis |
title_full |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis |
title_fullStr |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis |
title_full_unstemmed |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis |
title_sort |
T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis |
author |
Bittar, Rita C. |
author_facet |
Bittar, Rita C. Nogueira, Ricardo S. Gonçalves, Ricardo Vieira Ribeiro, Vanessa Pinho Mattos, Marise S. Oliveira Neto, Manoel Paes Coutinho, Sergio G. Cruz, Alda M. da |
author_role |
author |
author2 |
Nogueira, Ricardo S. Gonçalves, Ricardo Vieira Ribeiro, Vanessa Pinho Mattos, Marise S. Oliveira Neto, Manoel Paes Coutinho, Sergio G. Cruz, Alda M. da |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Bittar, Rita C. Nogueira, Ricardo S. Gonçalves, Ricardo Vieira Ribeiro, Vanessa Pinho Mattos, Marise S. Oliveira Neto, Manoel Paes Coutinho, Sergio G. Cruz, Alda M. da |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania (Viannia) braziliensis Infecção assintomática Leishmaniose curada Citocinas Subconjuntos de células T Imunidade a longo prazo |
topic |
Leishmania (Viannia) braziliensis Infecção assintomática Leishmaniose curada Citocinas Subconjuntos de células T Imunidade a longo prazo Asymptomatic infection Leishmania (Viannia) braziliensis Cured leishmaniasis Cytokines T-cell subsets Long term immunity |
dc.subject.en.pt_BR.fl_str_mv |
Asymptomatic infection Leishmania (Viannia) braziliensis Cured leishmaniasis Cytokines T-cell subsets Long term immunity |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2020-11-22T19:58:36Z |
dc.date.available.fl_str_mv |
2020-11-22T19:58:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BITTAR, Rita C. et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 5, p. 625-630, Aug. 2007. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44579 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762007005000069 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
BITTAR, Rita C. et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 5, p. 625-630, Aug. 2007. 0074-0276 10.1590/S0074-02762007005000069 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/44579 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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