Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)

Detalhes bibliográficos
Autor(a) principal: Meira, Cássio Santana
Data de Publicação: 2016
Outros Autores: Menezes, Leociley Rocha Alencar, Santos, Tatiana Barbosa dos, Macedo, Taís Soares, Fontes, José Eraldo do Nascimento, Costa, Emmanoel Vilaça, Pinheiro, Maria Lúcia Belém, Silva, Thanany Brasil da, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28001
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico [grant number 301837/2015-5]; Fundação de Amparo à Pesquisa do Estado da Bahia [grant number PET0042/2013]; Programa de Apoio a Núcleos de Excelência [grant number PNX0002/2014].
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spelling Meira, Cássio SantanaMenezes, Leociley Rocha AlencarSantos, Tatiana Barbosa dosMacedo, Taís SoaresFontes, José Eraldo do NascimentoCosta, Emmanoel VilaçaPinheiro, Maria Lúcia BelémSilva, Thanany Brasil daGuimarães, Elisalva TeixeiraSoares, Milena Botelho Pereira2018-08-08T12:45:31Z2018-08-08T12:45:31Z2016MEIRA, C. S. et al. Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae). Journal of Essential Oil Research, 2016.1041-2905https://www.arca.fiocruz.br/handle/icict/28001Conselho Nacional de Desenvolvimento Científico e Tecnológico [grant number 301837/2015-5]; Fundação de Amparo à Pesquisa do Estado da Bahia [grant number PET0042/2013]; Programa de Apoio a Núcleos de Excelência [grant number PNX0002/2014].Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil / Universidade Federal do Paraná. Centro de NMR. Curitiba, PR, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil / Universidade de Campinas. Instituto de Química. Campinas, SP, BrasilUniversidade Federal de Amazonas. Instituto de Ciências Exatas. Departamento de Química. Manaus, AM, BrasilUniversidade Federal de Amazonas. Instituto de Ciências Exatas. Departamento de Química. Manaus, AM, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilNatural products represent a valuable source for discovery of antiparasitic agents. Here, we describe the antiparasitic activity from essential oils extracted from leaves of Guatteria friesiana (EOGF) and Guatteria pogonopus (EOGP) (Annonaceae). The essential oils were obtained by hydrodistillation and analyzed by GC/MS and GC-FID. The sesquiterpenes are more abundant in both essential oils. G. friesiana are dominated by β-eudesmol (51.9%), γ-eudesmol (18.9%) andα-eudesmol (12.6%). The major compounds identified for EOGP were spathulenol (24.8%), γ-amorphene (14.7%) and germacrene D (11.8%). The essential oils demonstrated potent trypanocidal and antimalarial activities with values of IC50 lower than 41.3 μg/mL. EOGF also inhibits the proliferation of amastigotes. In addition, we identified significant ultrastructural alterations induced by the essential oils, especially in the cell membrane, Golgi complex, endoplasmatic reticulum and mitochondria. The results presented herein reinforce the potential of other members of this family for search of antiparasitic compounds.engTaylor & FrancisGuatteria friesianaGuatteria pogonopusÓleo essencialAtividade antimaláricaAtividade tripanocidaGuatteria friesianaGuatteria pogonopusEssential oilAntimalarial activityTrypanocidal activityChemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28001/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMeira CS Chemical composition and antiparasitic activity ....pdfMeira CS Chemical composition and antiparasitic activity 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dc.title.pt_BR.fl_str_mv Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
title Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
spellingShingle Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
Meira, Cássio Santana
Guatteria friesiana
Guatteria pogonopus
Óleo essencial
Atividade antimalárica
Atividade tripanocida
Guatteria friesiana
Guatteria pogonopus
Essential oil
Antimalarial activity
Trypanocidal activity
title_short Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
title_full Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
title_fullStr Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
title_full_unstemmed Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
title_sort Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae)
author Meira, Cássio Santana
author_facet Meira, Cássio Santana
Menezes, Leociley Rocha Alencar
Santos, Tatiana Barbosa dos
Macedo, Taís Soares
Fontes, José Eraldo do Nascimento
Costa, Emmanoel Vilaça
Pinheiro, Maria Lúcia Belém
Silva, Thanany Brasil da
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
author_role author
author2 Menezes, Leociley Rocha Alencar
Santos, Tatiana Barbosa dos
Macedo, Taís Soares
Fontes, José Eraldo do Nascimento
Costa, Emmanoel Vilaça
Pinheiro, Maria Lúcia Belém
Silva, Thanany Brasil da
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Meira, Cássio Santana
Menezes, Leociley Rocha Alencar
Santos, Tatiana Barbosa dos
Macedo, Taís Soares
Fontes, José Eraldo do Nascimento
Costa, Emmanoel Vilaça
Pinheiro, Maria Lúcia Belém
Silva, Thanany Brasil da
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
dc.subject.other.pt_BR.fl_str_mv Guatteria friesiana
Guatteria pogonopus
Óleo essencial
Atividade antimalárica
Atividade tripanocida
topic Guatteria friesiana
Guatteria pogonopus
Óleo essencial
Atividade antimalárica
Atividade tripanocida
Guatteria friesiana
Guatteria pogonopus
Essential oil
Antimalarial activity
Trypanocidal activity
dc.subject.en.pt_BR.fl_str_mv Guatteria friesiana
Guatteria pogonopus
Essential oil
Antimalarial activity
Trypanocidal activity
description Conselho Nacional de Desenvolvimento Científico e Tecnológico [grant number 301837/2015-5]; Fundação de Amparo à Pesquisa do Estado da Bahia [grant number PET0042/2013]; Programa de Apoio a Núcleos de Excelência [grant number PNX0002/2014].
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2018-08-08T12:45:31Z
dc.date.available.fl_str_mv 2018-08-08T12:45:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MEIRA, C. S. et al. Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae). Journal of Essential Oil Research, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28001
dc.identifier.issn.pt_BR.fl_str_mv 1041-2905
identifier_str_mv MEIRA, C. S. et al. Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae). Journal of Essential Oil Research, 2016.
1041-2905
url https://www.arca.fiocruz.br/handle/icict/28001
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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