Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice

Detalhes bibliográficos
Autor(a) principal: Carvalho, Vinicius F.
Data de Publicação: 2018
Outros Autores: Barreto, Emiliano O., Arantes, Ana Carolina S., Serra, Magda F., Ferreira, Tatiana Paula T., Jannini-Sá, Yago A. P., Hogaboam, Cory M., Martins, Marco A., Silva, Patrícia M. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28718
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.
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spelling Carvalho, Vinicius F.Barreto, Emiliano O.Arantes, Ana Carolina S.Serra, Magda F.Ferreira, Tatiana Paula T.Jannini-Sá, Yago A. P.Hogaboam, Cory M.Martins, Marco A.Silva, Patrícia M. R.2018-09-13T11:41:59Z2018-09-13T11:41:59Z2018CARVALHO, Vinicius F. et al. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators of Inflammation, Volume 2018, Article ID 6150843, 11p, 2018.0962-9351https://www.arca.fiocruz.br/handle/icict/2871810.1155/2018/61508431466-1861engHindawi Publishing CorporationDiabetesInflamaçãoVias aéreasCamundongosDiabetesInflammationAirwayMiceDiabetes Downregulates Allergen-Induced Airway Inflammation in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Universidade Federal de Alagoas. Maceió, AL, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Cedars-Sinai Medical Center. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Previous studies described that allergic diseases, including asthma, occur less often than expected in patients with type 1 diabetes. Here, we investigated the influence of diabetes on allergic airway inflammation in a model of experimental asthma in mice. Diabetes was induced by intravenous injection of alloxan into 12 h-fasted A/J mice, followed by subcutaneous sensitization with ovalbumin (OVA) and aluminum hydroxide (Al(OH)3), on days 5 and 19 after diabetes induction. Animals were intranasally challenged with OVA (25 μg), from day 24 to day 26. Alloxan-induced diabetes significantly attenuated airway inflammation as attested by the lower number of total leukocytes in the bronchoalveolar lavage fluid, mainly neutrophils and eosinophils. Suppression of eosinophil infiltration in the peribronchiolar space and generation of eosinophilotactic mediators, such as CCL-11/eotaxin, CCL-3/MIP-1α, and IL-5, were noted in the lungs of diabetic sensitized mice. In parallel, reduction of airway hyperreactivity (AHR) to methacholine, mucus production, and serum IgE levels was also noted under diabetic conditions. Our findings show that alloxan diabetes caused attenuation of lung allergic inflammatory response in A/J mice, by a mechanism possibly associated with downregulation of IgE antibody production.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28718/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanacarolina_arantes_etal_IOC_2018.pdfanacarolina_arantes_etal_IOC_2018.pdfapplication/pdf4071354https://www.arca.fiocruz.br/bitstream/icict/28718/2/anacarolina_arantes_etal_IOC_2018.pdfc6b9d12167748ddbf75f4c67e47643d0MD52TEXTanacarolina_arantes_etal_IOC_2018.pdf.txtanacarolina_arantes_etal_IOC_2018.pdf.txtExtracted texttext/plain49144https://www.arca.fiocruz.br/bitstream/icict/28718/3/anacarolina_arantes_etal_IOC_2018.pdf.txta8a357d400b44cb9f2cc4396f1a78654MD53icict/287182018-09-14 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dc.title.pt_BR.fl_str_mv Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
title Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
spellingShingle Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
Carvalho, Vinicius F.
Diabetes
Inflamação
Vias aéreas
Camundongos
Diabetes
Inflammation
Airway
Mice
title_short Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
title_full Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
title_fullStr Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
title_full_unstemmed Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
title_sort Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice
author Carvalho, Vinicius F.
author_facet Carvalho, Vinicius F.
Barreto, Emiliano O.
Arantes, Ana Carolina S.
Serra, Magda F.
Ferreira, Tatiana Paula T.
Jannini-Sá, Yago A. P.
Hogaboam, Cory M.
Martins, Marco A.
Silva, Patrícia M. R.
author_role author
author2 Barreto, Emiliano O.
Arantes, Ana Carolina S.
Serra, Magda F.
Ferreira, Tatiana Paula T.
Jannini-Sá, Yago A. P.
Hogaboam, Cory M.
Martins, Marco A.
Silva, Patrícia M. R.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Vinicius F.
Barreto, Emiliano O.
Arantes, Ana Carolina S.
Serra, Magda F.
Ferreira, Tatiana Paula T.
Jannini-Sá, Yago A. P.
Hogaboam, Cory M.
Martins, Marco A.
Silva, Patrícia M. R.
dc.subject.other.pt_BR.fl_str_mv Diabetes
Inflamação
Vias aéreas
Camundongos
topic Diabetes
Inflamação
Vias aéreas
Camundongos
Diabetes
Inflammation
Airway
Mice
dc.subject.en.pt_BR.fl_str_mv Diabetes
Inflammation
Airway
Mice
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-13T11:41:59Z
dc.date.available.fl_str_mv 2018-09-13T11:41:59Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Vinicius F. et al. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators of Inflammation, Volume 2018, Article ID 6150843, 11p, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28718
dc.identifier.issn.pt_BR.fl_str_mv 0962-9351
dc.identifier.doi.none.fl_str_mv 10.1155/2018/6150843
dc.identifier.eissn.none.fl_str_mv 1466-1861
identifier_str_mv CARVALHO, Vinicius F. et al. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators of Inflammation, Volume 2018, Article ID 6150843, 11p, 2018.
0962-9351
10.1155/2018/6150843
1466-1861
url https://www.arca.fiocruz.br/handle/icict/28718
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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