Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7824 |
Resumo: | James Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USA |
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Pearson, Mark S.Tribolet, LeonCantacessi, CinziaPeriago, Maria VictoriaValerio, Maria AdelaJariwala, Amar R.Hotez, Peter J.Diemert, David J.Loukas, AlexBethony, Jeffrey Michael2014-06-17T13:31:15Z2014-06-17T13:31:15Z2012PEARSON, Mark S. et al. Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines. Journal of Allergy and Clinical Immunology. 2012, vol.130, pp. 13-210091-6749https://www.arca.fiocruz.br/handle/icict/7824engElsevierMolecular mechanisms of hookworm disease: Stealth, virulence, and vaccinesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USAJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USAJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USAFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, BrasilUniversidad de Valencia. Departamento de Parasitologıa. Valencia, EspanhaGeorge Washington University.Department of Microbiology, Immunology and Tropical Medicine. Washington, USANational School of Tropical Medicine. Baylor College of Medicine, Department of Pediatrics and Molecular Virology and Microbiology. Houston, USA/Sabin Vaccine Institute. Texas Children’s Hospital. Center for Vaccine Development, Houston, USAGeorge Washington University.Department of Microbiology, Immunology and Tropical Medicine. Washington, USAJames Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USAGeorge Washington University.Department of Microbiology, Immunology and Tropical Medicine. Washington, USAHookworms produce a vast repertoire of structurally and functionally diverse molecules that mediate their long-term survival and pathogenesis within a human host. Many of these molecules are secreted by the parasite, after which they interact with critical components of host biology, including processes that are key to host survival. The most important of these interactions is the hookworm’s interruption of nutrient acquisition by the host through its ingestion and digestion of host blood. This results in iron deficiency and eventually the microcytic hypochromic anemia or iron deficiency anemia that is the clinical hallmark of hookworm infection. Other molecular mechanisms of hookworm infection cause a systematic suppression of the host immune response to both the parasite and to bystander antigens (eg, vaccines or allergens). This is achieved by a series of molecules that assist the parasite in the stealthy evasion of the host immune response. This review will summarize the current knowledge of the molecular mechanisms used by hookworms to survive for extended periods in the human host (up to 7 years or longer) and examine the pivotal contributions of these molecular mechanisms to chronic hookworm parasitism and host clinical outcomes.Hookwormsvirulence factorsimmune modulationvaccinesproteasesAncylostoma secreted proteinsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMolecular mechanisms of hookworm disease_ Stealth, virulence, and vaccines.pdfMolecular mechanisms of hookworm disease_ Stealth, virulence, and vaccines.pdfapplication/pdf2460045https://www.arca.fiocruz.br/bitstream/icict/7824/1/Molecular%20mechanisms%20of%20hookworm%20disease_%20Stealth%2c%20virulence%2c%20and%20vaccines.pdffc4890961b44dbe9cfbcfdb8f972e6e2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7824/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMolecular mechanisms of hookworm disease_ Stealth, virulence, and vaccines.pdf.txtMolecular mechanisms of hookworm disease_ Stealth, virulence, and vaccines.pdf.txtExtracted texttext/plain9https://www.arca.fiocruz.br/bitstream/icict/7824/5/Molecular%20mechanisms%20of%20hookworm%20disease_%20Stealth%2c%20virulence%2c%20and%20vaccines.pdf.txt33f4f15a16a9843faf6a25d4f387b6fdMD55THUMBNAILMolecular mechanisms of hookworm disease_ Stealth, virulence, and vaccines.pdf.jpgMolecular mechanisms of hookworm disease_ Stealth, virulence, and vaccines.pdf.jpgGenerated Thumbnailimage/jpeg2228https://www.arca.fiocruz.br/bitstream/icict/7824/4/Molecular%20mechanisms%20of%20hookworm%20disease_%20Stealth%2c%20virulence%2c%20and%20vaccines.pdf.jpg5a959aca3e531cedd4119df3790eb62fMD54icict/78242018-04-06 08:43:53.653oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:43:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines |
| title |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines |
| spellingShingle |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines Pearson, Mark S. Hookworms virulence factors immune modulation vaccines proteases Ancylostoma secreted proteins |
| title_short |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines |
| title_full |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines |
| title_fullStr |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines |
| title_full_unstemmed |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines |
| title_sort |
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines |
| author |
Pearson, Mark S. |
| author_facet |
Pearson, Mark S. Tribolet, Leon Cantacessi, Cinzia Periago, Maria Victoria Valerio, Maria Adela Jariwala, Amar R. Hotez, Peter J. Diemert, David J. Loukas, Alex Bethony, Jeffrey Michael |
| author_role |
author |
| author2 |
Tribolet, Leon Cantacessi, Cinzia Periago, Maria Victoria Valerio, Maria Adela Jariwala, Amar R. Hotez, Peter J. Diemert, David J. Loukas, Alex Bethony, Jeffrey Michael |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pearson, Mark S. Tribolet, Leon Cantacessi, Cinzia Periago, Maria Victoria Valerio, Maria Adela Jariwala, Amar R. Hotez, Peter J. Diemert, David J. Loukas, Alex Bethony, Jeffrey Michael |
| dc.subject.en.pt_BR.fl_str_mv |
Hookworms virulence factors immune modulation vaccines proteases Ancylostoma secreted proteins |
| topic |
Hookworms virulence factors immune modulation vaccines proteases Ancylostoma secreted proteins |
| description |
James Cook University. Center for Biodiscovery and Molecular Development of Therapeutics. Cairns, USA |
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2012 |
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2012 |
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2014-06-17T13:31:15Z |
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2014-06-17T13:31:15Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PEARSON, Mark S. et al. Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines. Journal of Allergy and Clinical Immunology. 2012, vol.130, pp. 13-21 |
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https://www.arca.fiocruz.br/handle/icict/7824 |
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0091-6749 |
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PEARSON, Mark S. et al. Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines. Journal of Allergy and Clinical Immunology. 2012, vol.130, pp. 13-21 0091-6749 |
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Elsevier |
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