Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29723 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil. |
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Gómez, Mariela MartínezAbreu, Filipe Vieira Santos deSantos, Alexandre Araujo Cunha dosMello, Isamin Silva deSantos, Marta PereiraRibeiro, Ieda PereiraBrito, Anielly Ferreira deMiranda, Rafaella Moraes deCastro, Marcia Gonçalves deRibeiro, Mario SergioLaterrière Junior, Roberto da CostaAguiar, Shirlei FerreiraMeira, Guilherme Louzada SilvaAntunes, DeborahTorres, Pedro Henrique MonteiroVicente, Ana Carolina PauloGuimarães, Ana Carolina RamosCaffarena, Ernesto RaulBello, GonzalloOliveira, Ricardo Lourenço deBonaldo, Myrna Cristina2018-10-25T15:11:24Z2018-10-25T15:11:24Z2018GOMÉZ, Mariela Martínez et al. Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak. Journal of General Virology, v. 99, p. 536-548, Feb. 2018.https://www.arca.fiocruz.br/handle/icict/29723engMicrobiology SocietyGenomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreakinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil / Instituto Federal do Norte de Minas Gerais. Salinas, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Secretaria Estadual de Saúde. Superintendência de Vigilância Epidemiológica e Ambiental. Rio de Janeiro, RJ, Brasil.Secretaria Estadual de Saúde do Espírito Santo. Núcleo Especial de Vigilância Ambiental. Vitória, ES, Brasil.Laboratório Central de Saúde Pública Noel Nutels. Rio de Janeiro, RJ, Brasil.Laboratório Central de Saúde Pública Noel Nutels. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Brazil has been suffering a severe sylvatic epidemic of yellow fever virus (YFV) since late 2016. Analysis of full-length YFV genomes from all hosts involved in the Brazilian 2017 outbreak reveals that they belong to sub-lineage 1E within modern lineage, but display several unique amino acid substitutions in highly conserved positions at NS3 and NS5 viral proteins. Evolutionary analyses indicate that YFV carrying that set of amino acid substitution circulates in the Southern Brazilian region for several months before being detected in December 2016. Structural and selection analyses support tha some of these substitutions were under positive selection and could impact enzyme structure and function. Altogether, this evidence demonstrated that the current Brazilian YFV carries unique amino acid signatures in the non-structural proteins and support the hypothesis that those substitutions may be affecting the viral fitness and transmissibility.2016-2017 Brazilian outbreakEvolutionAmino acid changesGenetic diversityYellow fever virusNãoNão Publicadoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29723/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRicardoL_oliveira_etal_IOC_2018.pdfRicardoL_oliveira_etal_IOC_2018.pdfapplication/pdf5765668https://www.arca.fiocruz.br/bitstream/icict/29723/2/RicardoL_oliveira_etal_IOC_2018.pdf8aecf8d9f75ac85202a32f65d8b5289aMD52TEXTRicardoL_oliveira_etal_IOC_2018.pdf.txtRicardoL_oliveira_etal_IOC_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak |
| title |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak |
| spellingShingle |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak Gómez, Mariela Martínez 2016-2017 Brazilian outbreak Evolution Amino acid changes Genetic diversity Yellow fever virus |
| title_short |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak |
| title_full |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak |
| title_fullStr |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak |
| title_full_unstemmed |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak |
| title_sort |
Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak |
| author |
Gómez, Mariela Martínez |
| author_facet |
Gómez, Mariela Martínez Abreu, Filipe Vieira Santos de Santos, Alexandre Araujo Cunha dos Mello, Isamin Silva de Santos, Marta Pereira Ribeiro, Ieda Pereira Brito, Anielly Ferreira de Miranda, Rafaella Moraes de Castro, Marcia Gonçalves de Ribeiro, Mario Sergio Laterrière Junior, Roberto da Costa Aguiar, Shirlei Ferreira Meira, Guilherme Louzada Silva Antunes, Deborah Torres, Pedro Henrique Monteiro Vicente, Ana Carolina Paulo Guimarães, Ana Carolina Ramos Caffarena, Ernesto Raul Bello, Gonzallo Oliveira, Ricardo Lourenço de Bonaldo, Myrna Cristina |
| author_role |
author |
| author2 |
Abreu, Filipe Vieira Santos de Santos, Alexandre Araujo Cunha dos Mello, Isamin Silva de Santos, Marta Pereira Ribeiro, Ieda Pereira Brito, Anielly Ferreira de Miranda, Rafaella Moraes de Castro, Marcia Gonçalves de Ribeiro, Mario Sergio Laterrière Junior, Roberto da Costa Aguiar, Shirlei Ferreira Meira, Guilherme Louzada Silva Antunes, Deborah Torres, Pedro Henrique Monteiro Vicente, Ana Carolina Paulo Guimarães, Ana Carolina Ramos Caffarena, Ernesto Raul Bello, Gonzallo Oliveira, Ricardo Lourenço de Bonaldo, Myrna Cristina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gómez, Mariela Martínez Abreu, Filipe Vieira Santos de Santos, Alexandre Araujo Cunha dos Mello, Isamin Silva de Santos, Marta Pereira Ribeiro, Ieda Pereira Brito, Anielly Ferreira de Miranda, Rafaella Moraes de Castro, Marcia Gonçalves de Ribeiro, Mario Sergio Laterrière Junior, Roberto da Costa Aguiar, Shirlei Ferreira Meira, Guilherme Louzada Silva Antunes, Deborah Torres, Pedro Henrique Monteiro Vicente, Ana Carolina Paulo Guimarães, Ana Carolina Ramos Caffarena, Ernesto Raul Bello, Gonzallo Oliveira, Ricardo Lourenço de Bonaldo, Myrna Cristina |
| dc.subject.en.pt_BR.fl_str_mv |
2016-2017 Brazilian outbreak Evolution Amino acid changes Genetic diversity Yellow fever virus |
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2016-2017 Brazilian outbreak Evolution Amino acid changes Genetic diversity Yellow fever virus |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil. |
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2018 |
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2018-10-25T15:11:24Z |
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2018-10-25T15:11:24Z |
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2018 |
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info:eu-repo/semantics/article |
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GOMÉZ, Mariela Martínez et al. Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak. Journal of General Virology, v. 99, p. 536-548, Feb. 2018. |
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https://www.arca.fiocruz.br/handle/icict/29723 |
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GOMÉZ, Mariela Martínez et al. Genomic and structural features of 1 the Yellow Fever virus from the 2016-2017 Brazilian outbreak. Journal of General Virology, v. 99, p. 536-548, Feb. 2018. |
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Microbiology Society |
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