Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57498 |
Resumo: | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil. |
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Santos, Rosiane Freire dosSilva, Thayssa DaBrito, Andréia Carolinne de SouzaInácio, Job DomingosVentura, Bianca DominguesMendes, Michely Aparecida PolidoAzevedo, Bruno FonsecaSiqueira, Larissa MoreiraAmaral, Elmo Eduardo AlmeidaDutra, Patrícia Maria LourençoSilva, Silvia Amaral Gonçalves Da2023-03-22T14:01:40Z2023-03-22T14:01:40Z2023SANTOS, Rosiane Freire et al. Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis. Frontiers in Cellular and Infection Microbiology, v. 12, 1059168, p. 1 - 11, Jan. 2023.2235-2988https://www.arca.fiocruz.br/handle/icict/5749810.3389/fcimb.2022.1059168engFrontiers MediaQuercetinaLeishmania brasiliensisHamstersEspécies reativas de oxigênioTratamento oralQuercetinLeishmania braziliensisHamstersReactive species of oxygenOral treatmentTherapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Laboratório de Imunofisiologia do Exercício. Disciplina de Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Leishmaniasis is a parasitic disease caused by several species of intracellular protozoa of the genus Leishmania that present manifestations ranging from cutaneous ulcers to the fatal visceral form. Leishmania Viannia braziliensis is an important species associated with American tegumentary leishmaniasis and the main agent in Brazil, with variable sensitivity to available drugs. The search for new therapeutic alternatives to treat leishmaniasis is an urgent need, especially for endemic countries. Not only is quercetin well known for its antioxidant activity in radical scavenging but also several other biological effects are described, including anti-inflammatory, antimicrobial, and pro-oxidant activities. This study aimed to investigate the flavonoid quercetin’s therapeutic potential in L. (V.) braziliensis infection. Quercetin showed antiamastigote (IC50 of 21 ± 2.5 μM) and antipromastigote (25 ± 0.7 μM) activities and a selectivity index of 22. The treatment of uninfected or L. (V.) braziliensis–infected macrophages with quercetin increased reactive oxygen species (ROS)/H202 generation without altering Nitric Oxide (NO) production. Oral treatment with quercetin of infected hamsters, starting at 1 week of infection for 8 weeks, reduced the lesion thickness (p > 0.01) and parasite load (p > 0.001). The results of this study suggest that the antiamastigote activity of the flavonoid quercetin in vitro is associated, at least in part, with the modulation of ROS production by macrophages. The efficacy of oral quercetin treatment in hamsters infected with L. (V.) braziliensis was presented for the first time and shows its promising therapeutic potential.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57498/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJobInacio_ElmoAmaral_etal_IOC_2023.pdfJobInacio_ElmoAmaral_etal_IOC_2023.pdfapplication/pdf2280231https://www.arca.fiocruz.br/bitstream/icict/57498/2/JobInacio_ElmoAmaral_etal_IOC_2023.pdfdcbc841319b19a5bca22c4cb09b09887MD52icict/574982023-09-04 11:03:11.087oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:03:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis |
| title |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis |
| spellingShingle |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis Santos, Rosiane Freire dos Quercetina Leishmania brasiliensis Hamsters Espécies reativas de oxigênio Tratamento oral Quercetin Leishmania braziliensis Hamsters Reactive species of oxygen Oral treatment |
| title_short |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis |
| title_full |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis |
| title_fullStr |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis |
| title_full_unstemmed |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis |
| title_sort |
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis |
| author |
Santos, Rosiane Freire dos |
| author_facet |
Santos, Rosiane Freire dos Silva, Thayssa Da Brito, Andréia Carolinne de Souza Inácio, Job Domingos Ventura, Bianca Domingues Mendes, Michely Aparecida Polido Azevedo, Bruno Fonseca Siqueira, Larissa Moreira Amaral, Elmo Eduardo Almeida Dutra, Patrícia Maria Lourenço Silva, Silvia Amaral Gonçalves Da |
| author_role |
author |
| author2 |
Silva, Thayssa Da Brito, Andréia Carolinne de Souza Inácio, Job Domingos Ventura, Bianca Domingues Mendes, Michely Aparecida Polido Azevedo, Bruno Fonseca Siqueira, Larissa Moreira Amaral, Elmo Eduardo Almeida Dutra, Patrícia Maria Lourenço Silva, Silvia Amaral Gonçalves Da |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Rosiane Freire dos Silva, Thayssa Da Brito, Andréia Carolinne de Souza Inácio, Job Domingos Ventura, Bianca Domingues Mendes, Michely Aparecida Polido Azevedo, Bruno Fonseca Siqueira, Larissa Moreira Amaral, Elmo Eduardo Almeida Dutra, Patrícia Maria Lourenço Silva, Silvia Amaral Gonçalves Da |
| dc.subject.other.en_US.fl_str_mv |
Quercetina Leishmania brasiliensis Hamsters Espécies reativas de oxigênio Tratamento oral |
| topic |
Quercetina Leishmania brasiliensis Hamsters Espécies reativas de oxigênio Tratamento oral Quercetin Leishmania braziliensis Hamsters Reactive species of oxygen Oral treatment |
| dc.subject.en.en_US.fl_str_mv |
Quercetin Leishmania braziliensis Hamsters Reactive species of oxygen Oral treatment |
| description |
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil. |
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2023 |
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2023-03-22T14:01:40Z |
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2023-03-22T14:01:40Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SANTOS, Rosiane Freire et al. Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis. Frontiers in Cellular and Infection Microbiology, v. 12, 1059168, p. 1 - 11, Jan. 2023. |
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https://www.arca.fiocruz.br/handle/icict/57498 |
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2235-2988 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2022.1059168 |
| identifier_str_mv |
SANTOS, Rosiane Freire et al. Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis. Frontiers in Cellular and Infection Microbiology, v. 12, 1059168, p. 1 - 11, Jan. 2023. 2235-2988 10.3389/fcimb.2022.1059168 |
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