Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution

Detalhes bibliográficos
Autor(a) principal: Maufrais, Corinne
Data de Publicação: 2021
Outros Autores: Oliveira, Luciana de, Bastos, Rafael Wesley, Moyrand, Frédérique, Reis, Flavia Coelho Garcia dos, Valero, Clara, Gimenez, Bianca, Josefowicz, Luisa J., Goldman, Gustavo H., Rodrigues, Marcio Lourenço, Janbon, Guilhem
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47647
Resumo: Institut Pasteur. Département de Mycologie. Unité Biologie des ARN des Pathogènes Fongiques. Paris, France / Institut Pasteur. Hub de Bioinformatique et Biostatistique. Paris, France.
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spelling Maufrais, CorinneOliveira, Luciana deBastos, Rafael WesleyMoyrand, FrédériqueReis, Flavia Coelho Garcia dosValero, ClaraGimenez, BiancaJosefowicz, Luisa J.Goldman, Gustavo H.Rodrigues, Marcio LourençoJanbon, Guilhem2021-06-11T14:31:04Z2021-06-11T14:31:04Z2021MAUFRAIS, Corinne et al. Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution. G3, p. 1–12, 2021.2160-1836https://www.arca.fiocruz.br/handle/icict/4764710.1093/g3journal/jkab107porGenetics Society of America. Oxford University PressCryptococcus deuterogattiiGenomephylogenetic treePhylogeographyFilogeografíaGénomePhylogéographieCryptococcus neoformansCryptococcus gattiiGenomaFilogeografiaPopulation genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distributioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitut Pasteur. Département de Mycologie. Unité Biologie des ARN des Pathogènes Fongiques. Paris, France / Institut Pasteur. Hub de Bioinformatique et Biostatistique. Paris, France.Institut Pasteur. Département de Mycologie. Unité Biologie des ARN des Pathogènes Fongiques. Paris, France.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil.Institut Pasteur. Département de Mycologie. Unité Biologie des ARN des Pathogènes Fongiques. Paris, France.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro RJ, Brasil.Institut Pasteur. Département de Mycologie. Unité Biologie des ARN des Pathogènes Fongiques. Paris, France.The genomes of a large number of Cryptococcus neoformans isolates have been sequenced and analyzed in recent years. These genomes have been used to understand the global population structure of this opportunistic pathogen. However, only a small number of South American isolates have been considered in these studies, and the population structure of C. neoformans in this part of the world remains elusive. Here, we analyzed the genomic sequences of 53 Brazilian Cryptococcus isolates and deciphered the C. neoformans population structure in this country. Our data reveal an African-like structure that suggested repeated intercontinental transports from Africa to South America. We also identified a mutator phenotype in one VNBII Brazilian isolate, exemplifying how fast-evolving isolates can shape the Cryptococcus population structure. Finally, phenotypic analyses revealed wide diversity but not lineage specificity in the expression of classical virulence traits within the set of isolates.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/47647/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALjkab107ok.pdfjkab107ok.pdfapplication/pdf916173https://www.arca.fiocruz.br/bitstream/icict/47647/2/jkab107ok.pdff9a1316140453088163dd784215f3506MD52TEXTjkab107ok.pdf.txtjkab107ok.pdf.txtExtracted texttext/plain58762https://www.arca.fiocruz.br/bitstream/icict/47647/3/jkab107ok.pdf.txtb60be6de2f1f0cd632a96655d7bce3b4MD53icict/476472022-01-12 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dc.title.pt_BR.fl_str_mv Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
title Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
spellingShingle Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
Maufrais, Corinne
Cryptococcus deuterogattii
Genome
phylogenetic tree
Phylogeography
Filogeografía
Génome
Phylogéographie
Cryptococcus neoformans
Cryptococcus gattii
Genoma
Filogeografia
title_short Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
title_full Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
title_fullStr Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
title_full_unstemmed Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
title_sort Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
author Maufrais, Corinne
author_facet Maufrais, Corinne
Oliveira, Luciana de
Bastos, Rafael Wesley
Moyrand, Frédérique
Reis, Flavia Coelho Garcia dos
Valero, Clara
Gimenez, Bianca
Josefowicz, Luisa J.
Goldman, Gustavo H.
Rodrigues, Marcio Lourenço
Janbon, Guilhem
author_role author
author2 Oliveira, Luciana de
Bastos, Rafael Wesley
Moyrand, Frédérique
Reis, Flavia Coelho Garcia dos
Valero, Clara
Gimenez, Bianca
Josefowicz, Luisa J.
Goldman, Gustavo H.
Rodrigues, Marcio Lourenço
Janbon, Guilhem
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maufrais, Corinne
Oliveira, Luciana de
Bastos, Rafael Wesley
Moyrand, Frédérique
Reis, Flavia Coelho Garcia dos
Valero, Clara
Gimenez, Bianca
Josefowicz, Luisa J.
Goldman, Gustavo H.
Rodrigues, Marcio Lourenço
Janbon, Guilhem
dc.subject.other.pt_BR.fl_str_mv Cryptococcus deuterogattii
topic Cryptococcus deuterogattii
Genome
phylogenetic tree
Phylogeography
Filogeografía
Génome
Phylogéographie
Cryptococcus neoformans
Cryptococcus gattii
Genoma
Filogeografia
dc.subject.en.pt_BR.fl_str_mv Genome
phylogenetic tree
Phylogeography
dc.subject.es.pt_BR.fl_str_mv Filogeografía
dc.subject.fr.pt_BR.fl_str_mv Génome
Phylogéographie
dc.subject.decs.pt_BR.fl_str_mv Cryptococcus neoformans
Cryptococcus gattii
Genoma
Filogeografia
description Institut Pasteur. Département de Mycologie. Unité Biologie des ARN des Pathogènes Fongiques. Paris, France / Institut Pasteur. Hub de Bioinformatique et Biostatistique. Paris, France.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-11T14:31:04Z
dc.date.available.fl_str_mv 2021-06-11T14:31:04Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAUFRAIS, Corinne et al. Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution. G3, p. 1–12, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47647
dc.identifier.issn.pt_BR.fl_str_mv 2160-1836
dc.identifier.doi.none.fl_str_mv 10.1093/g3journal/jkab107
identifier_str_mv MAUFRAIS, Corinne et al. Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution. G3, p. 1–12, 2021.
2160-1836
10.1093/g3journal/jkab107
url https://www.arca.fiocruz.br/handle/icict/47647
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Genetics Society of America. Oxford University Press
publisher.none.fl_str_mv Genetics Society of America. Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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