In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion

Detalhes bibliográficos
Autor(a) principal: Castro Neto, Artur L.
Data de Publicação: 2019
Outros Autores: Brito, Adriana N. A. L. M., Rezende, Antonio M., Magalhães, Franklin B., Melo Neto, Osvaldo P. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36220
Resumo: Universidade Federal de Pernambuco. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
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spelling Castro Neto, Artur L.Brito, Adriana N. A. L. M.Rezende, Antonio M.Magalhães, Franklin B.Melo Neto, Osvaldo P. de2019-10-07T13:37:42Z2019-10-07T13:37:42Z2019CASTRO NETO, Artur L. et al. In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion. BMC Genomics, v. 20, n. 1, p. 1-17 Feb. 2019.1471-2164https://www.arca.fiocruz.br/handle/icict/3622010.1186/s12864-019-5465-zengIn silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Centro Universitário Tabosa de Almeida - ASCES/UNITA. Caruaru, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.The leishmaniasis are parasitic diseases caused by protozoans of the genus Leishmania, highly divergent eukaryotes, characterized by unique biological features. To survive in both the mammalian hosts and insect vectors, these pathogens make use of a number of mechanisms, many of which are associated with parasite specific proteases. The metalloprotease GP63, the major Leishmania surface antigen, has been found to have multiple functions required for the parasite's survival. GP63 is encoded by multiple genes and their copy numbers vary considerably between different species and are increased in those from the subgenus Viannia, including L. braziliensis.GP63Leishmania braziliensisVirulence proteinsSequência de AminoácidosCromossomos / genéticaSimulação por ComputadorEpitopos de Linfócito B / imunologiaEvolução MolecularVariação GenéticaEvasão da Resposta Imune / genéticaLeishmania braziliensis / genéticaLeishmania braziliensis / imunologiaLeishmania braziliensis / patogenicidadeMetaloendopeptidases / químicaMetaloendopeptidases / genéticaRecombinação GenéticaHomologia de Sequência do Ácido Nucleicopatogenicidade / genéticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83085https://www.arca.fiocruz.br/bitstream/icict/36220/1/license.txt4194663c61da82c21746deb8d6361188MD51ORIGINALIn silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis.pdfIn silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis.pdfapplication/pdf3404079https://www.arca.fiocruz.br/bitstream/icict/36220/2/In%20silico%20characterization%20of%20multiple%20genes%20encoding%20the%20GP63%20virulence%20protein%20from%20Leishmania%20braziliensis.pdfd1719647727e55a8e68c9cbdb3497f06MD52TEXTIn silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis.pdf.txtIn silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis.pdf.txtExtracted texttext/plain77661https://www.arca.fiocruz.br/bitstream/icict/36220/3/In%20silico%20characterization%20of%20multiple%20genes%20encoding%20the%20GP63%20virulence%20protein%20from%20Leishmania%20braziliensis.pdf.txt3c229dd8380f192a7e9f144aee8bc1e9MD53icict/362202019-10-28 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dc.title.pt_BR.fl_str_mv In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
title In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
spellingShingle In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
Castro Neto, Artur L.
GP63
Leishmania braziliensis
Virulence proteins
Sequência de Aminoácidos
Cromossomos / genética
Simulação por Computador
Epitopos de Linfócito B / imunologia
Evolução Molecular
Variação Genética
Evasão da Resposta Imune / genética
Leishmania braziliensis / genética
Leishmania braziliensis / imunologia
Leishmania braziliensis / patogenicidade
Metaloendopeptidases / química
Metaloendopeptidases / genética
Recombinação Genética
Homologia de Sequência do Ácido Nucleico
patogenicidade / genética
title_short In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
title_full In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
title_fullStr In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
title_full_unstemmed In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
title_sort In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion
author Castro Neto, Artur L.
author_facet Castro Neto, Artur L.
Brito, Adriana N. A. L. M.
Rezende, Antonio M.
Magalhães, Franklin B.
Melo Neto, Osvaldo P. de
author_role author
author2 Brito, Adriana N. A. L. M.
Rezende, Antonio M.
Magalhães, Franklin B.
Melo Neto, Osvaldo P. de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Castro Neto, Artur L.
Brito, Adriana N. A. L. M.
Rezende, Antonio M.
Magalhães, Franklin B.
Melo Neto, Osvaldo P. de
dc.subject.en.pt_BR.fl_str_mv GP63
Leishmania braziliensis
Virulence proteins
topic GP63
Leishmania braziliensis
Virulence proteins
Sequência de Aminoácidos
Cromossomos / genética
Simulação por Computador
Epitopos de Linfócito B / imunologia
Evolução Molecular
Variação Genética
Evasão da Resposta Imune / genética
Leishmania braziliensis / genética
Leishmania braziliensis / imunologia
Leishmania braziliensis / patogenicidade
Metaloendopeptidases / química
Metaloendopeptidases / genética
Recombinação Genética
Homologia de Sequência do Ácido Nucleico
patogenicidade / genética
dc.subject.decs.pt_BR.fl_str_mv Sequência de Aminoácidos
Cromossomos / genética
Simulação por Computador
Epitopos de Linfócito B / imunologia
Evolução Molecular
Variação Genética
Evasão da Resposta Imune / genética
Leishmania braziliensis / genética
Leishmania braziliensis / imunologia
Leishmania braziliensis / patogenicidade
Metaloendopeptidases / química
Metaloendopeptidases / genética
Recombinação Genética
Homologia de Sequência do Ácido Nucleico
patogenicidade / genética
description Universidade Federal de Pernambuco. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-10-07T13:37:42Z
dc.date.available.fl_str_mv 2019-10-07T13:37:42Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO NETO, Artur L. et al. In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion. BMC Genomics, v. 20, n. 1, p. 1-17 Feb. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36220
dc.identifier.issn.pt_BR.fl_str_mv 1471-2164
dc.identifier.doi.none.fl_str_mv 10.1186/s12864-019-5465-z
identifier_str_mv CASTRO NETO, Artur L. et al. In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion. BMC Genomics, v. 20, n. 1, p. 1-17 Feb. 2019.
1471-2164
10.1186/s12864-019-5465-z
url https://www.arca.fiocruz.br/handle/icict/36220
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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