Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization

Detalhes bibliográficos
Autor(a) principal: Macêdo, Simone Regina Barros de
Data de Publicação: 2018
Outros Autores: Lima, Luiz André Rodrigues de, Torres, Sandra Maria de, Oliveira, Vinícius Vasconcelos Gomes de, Morais, Rosana Nogueira de, Peixoto, Christina Alves, Tenorio, Bruno Mendes, Junior, Valdemiro Amaro da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37009
Resumo: Federal Rural Universidade de Pernambuco Universidade Federal de Paraná Instituto Aggeu Magalhães
id CRUZ_c366d94e3f7f30dc6f5990cb16669bee
oai_identifier_str oai:www.arca.fiocruz.br:icict/37009
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Macêdo, Simone Regina Barros deLima, Luiz André Rodrigues deTorres, Sandra Maria deOliveira, Vinícius Vasconcelos Gomes deMorais, Rosana Nogueira dePeixoto, Christina AlvesTenorio, Bruno MendesJunior, Valdemiro Amaro da Silva2019-11-12T15:18:50Z2019-11-12T15:18:50Z2018MACÊDO, Simone Regina Barros de et al. Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization. Veterinary World, v. 11, n. 5, p. 649-656, May 2018.0972-8988https://www.arca.fiocruz.br/handle/icict/3700910.14202/vetworld.2018.649-6562231-0916Federal Rural Universidade de Pernambuco Universidade Federal de Paraná Instituto Aggeu MagalhãesUniversidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil.Universidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil.Universidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil.Universidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil.Universidade Federal do Paraná. Departamento de Fisiologia. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil.Universidade Federal da Paraíba. Departamento de Morfologia. João Pessoa, PB, Brasil.Universidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil.Aim: Chemical sterilization is a non-surgical method of contraception based on compounds injected into the testis to induce infertility. However, these injections can cause discomfort and pain able to impair the recovery of animals after this treatment. The objective of this study was to investigate if anti-inflammatories or pain relievers inhibited the sterilizing effect of zinc gluconate-based solution on the testis. Materials and Methods: Adult rats were treated in groups: G1 (control), G2 (dimethyl sulfoxide + dipyrone); G3 (dipyrone/zinc); G4 (dipyrone + celecoxib/zinc); G5 (dipyrone + meloxicam/zinc), and G6 (dipyrone + dexamethasone/zinc) in a single dose per day during 7 days. Animals were analyzed at 7, 15, and 30 days after treatments. Results: The zinc-induced a widespread testicular degeneration and decreased testosterone levels even in combination with antiinflammatories or pain relievers. Testis, epididymis, prostate, and seminal vesicle had a weight reduction. The anti-inflammatory effect of dexamethasone interfered in the desired action of zinc gluconate in the 1st 15 days and celecoxib up to 7 days. Conclusion: Meloxicam plus dipyrone did not impair the chemical sterilization based on zinc gluconate, and it can be used to reduce nociceptive effects in animals after chemical sterilization.engEffects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAnalgesicAnti-inflammatoryContraceptionTesticular degenerationZinc gluconateAnalgésicosAnti-InflamatóriosAnticoncepçãoZincoGluconatosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83085https://www.arca.fiocruz.br/bitstream/icict/37009/1/license.txt4194663c61da82c21746deb8d6361188MD51ORIGINALEffects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization.pdfEffects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization.pdfapplication/pdf1192904https://www.arca.fiocruz.br/bitstream/icict/37009/2/Effects%20of%20intratesticular%20injection%20of%20zinc-based%20solution%20in%20rats%20in%20combination%20with%20anti-inflammatory%20and%20analgesic%20drugs%20during%20chemical%20sterilization.pdf0f33877337bb9d4a1aa8bc2ec2803480MD52TEXTEffects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization.pdf.txtEffects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization.pdf.txtExtracted texttext/plain37167https://www.arca.fiocruz.br/bitstream/icict/37009/3/Effects%20of%20intratesticular%20injection%20of%20zinc-based%20solution%20in%20rats%20in%20combination%20with%20anti-inflammatory%20and%20analgesic%20drugs%20during%20chemical%20sterilization.pdf.txt225b93c449fdae17a74102ab532364ecMD53icict/370092019-12-22 11:43:31.269oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-12-22T14:43:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
title Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
spellingShingle Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
Macêdo, Simone Regina Barros de
Analgesic
Anti-inflammatory
Contraception
Testicular degeneration
Zinc gluconate
Analgésicos
Anti-Inflamatórios
Anticoncepção
Zinco
Gluconatos
title_short Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
title_full Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
title_fullStr Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
title_full_unstemmed Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
title_sort Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization
author Macêdo, Simone Regina Barros de
author_facet Macêdo, Simone Regina Barros de
Lima, Luiz André Rodrigues de
Torres, Sandra Maria de
Oliveira, Vinícius Vasconcelos Gomes de
Morais, Rosana Nogueira de
Peixoto, Christina Alves
Tenorio, Bruno Mendes
Junior, Valdemiro Amaro da Silva
author_role author
author2 Lima, Luiz André Rodrigues de
Torres, Sandra Maria de
Oliveira, Vinícius Vasconcelos Gomes de
Morais, Rosana Nogueira de
Peixoto, Christina Alves
Tenorio, Bruno Mendes
Junior, Valdemiro Amaro da Silva
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macêdo, Simone Regina Barros de
Lima, Luiz André Rodrigues de
Torres, Sandra Maria de
Oliveira, Vinícius Vasconcelos Gomes de
Morais, Rosana Nogueira de
Peixoto, Christina Alves
Tenorio, Bruno Mendes
Junior, Valdemiro Amaro da Silva
dc.subject.en.pt_BR.fl_str_mv Analgesic
Anti-inflammatory
Contraception
Testicular degeneration
Zinc gluconate
topic Analgesic
Anti-inflammatory
Contraception
Testicular degeneration
Zinc gluconate
Analgésicos
Anti-Inflamatórios
Anticoncepção
Zinco
Gluconatos
dc.subject.decs.pt_BR.fl_str_mv Analgésicos
Anti-Inflamatórios
Anticoncepção
Zinco
Gluconatos
description Federal Rural Universidade de Pernambuco Universidade Federal de Paraná Instituto Aggeu Magalhães
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-11-12T15:18:50Z
dc.date.available.fl_str_mv 2019-11-12T15:18:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACÊDO, Simone Regina Barros de et al. Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization. Veterinary World, v. 11, n. 5, p. 649-656, May 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37009
dc.identifier.issn.pt_BR.fl_str_mv 0972-8988
dc.identifier.doi.none.fl_str_mv 10.14202/vetworld.2018.649-656
dc.identifier.eissn.none.fl_str_mv 2231-0916
identifier_str_mv MACÊDO, Simone Regina Barros de et al. Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization. Veterinary World, v. 11, n. 5, p. 649-656, May 2018.
0972-8988
10.14202/vetworld.2018.649-656
2231-0916
url https://www.arca.fiocruz.br/handle/icict/37009
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/37009/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/37009/2/Effects%20of%20intratesticular%20injection%20of%20zinc-based%20solution%20in%20rats%20in%20combination%20with%20anti-inflammatory%20and%20analgesic%20drugs%20during%20chemical%20sterilization.pdf
https://www.arca.fiocruz.br/bitstream/icict/37009/3/Effects%20of%20intratesticular%20injection%20of%20zinc-based%20solution%20in%20rats%20in%20combination%20with%20anti-inflammatory%20and%20analgesic%20drugs%20during%20chemical%20sterilization.pdf.txt
bitstream.checksum.fl_str_mv 4194663c61da82c21746deb8d6361188
0f33877337bb9d4a1aa8bc2ec2803480
225b93c449fdae17a74102ab532364ec
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324652754337792

Registros relacionados