Galectin-3 Regulates the Innate Immune Response of Human Monocytes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11742 |
Resumo: | John Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA. |
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Chung, Andrew W.Sieling, Peter A.Schenk, MirjamTeles, Rosane M. B.Krutzik, Stephan R.Hsu, Daniel K.Liu, Fu-TongSarno, Euzenir N.Rea, Thomas H.Stenger, SteffenModlin, Robert L.Lee, Delphine J.2015-09-21T17:25:35Z2015-09-21T17:25:35Z2013CHUNG, Andrew W.; et al. Galectin-3 Regulates the Innate Immune Response of Human Monocytes. J. Infect Dis., v.207, n.6, p.947-956, 2013.0022-18991537-6613https://www.arca.fiocruz.br/handle/icict/1174210.1093/infdis/jis920engOxford University PressGalectin-3 Regulates the Innate Immune Response of Human Monocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohn Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA.John Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA.University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA.University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA.University of California. Davis School of Medicine. Department of Dermatology. Sacramento, USA / Academia Sinica. Institute of BioMedical Sciences. Taipei, Taiwan, Republic of China.University of California. Davis School of Medicine. Department of Dermatology. Sacramento, USA / Academia Sinica. Institute of BioMedical Sciences. Taipei, Taiwan, Republic of China.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.University of Southern California. School of Medicine. Department of Dermatology. Los Angeles, USA.University Hospital of Ulm. Institute for Medical Microbiology and Hygiene. Germany.University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA / University of California. David Geffen School of Medicine. Department of Microbiology, Immunology, and Molecular Genetics. Los Angeles, USA.John Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA.Galectin-3 is a β-galactoside–binding lectin widely expressed on epithelial and hematopoietic cells, and its expression is frequently associated with a poor prognosis in cancer. Because it has not been well-studied in human infectious disease, we examined galectin-3 expression in mycobacterial infection by studying leprosy, an intracellular infection caused by Mycobacterium leprae. Galectin-3 was highly expressed on macrophages in lesions of patients with the clinically progressive lepromatous form of leprosy; in contrast, galectin-3 was almost undetectable in self-limited tuberculoid lesions. We investigated the potential function of galectin-3 in cell-mediated immunity using peripheral blood monocytes. Galectin-3 enhanced monocyte interleukin 10 production to a TLR2/1 ligand, whereas interleukin 12p40 secretion was unaffected. Furthermore, galectin-3 diminished monocyte to dendritic cell differentiation and T-cell antigen presentation. These data demonstrate an association of galectin- 3 with unfavorable host response in leprosy and a potential mechanism for impaired host defense in humans.HumanBacterial infectionGalectin-3Monocytes/macrophages;TLR2nfecções BacterianasMonócitosMacrófagosHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11742/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALrosane_teles_etal_IOC-2013.pdfapplication/pdf8010497https://www.arca.fiocruz.br/bitstream/icict/11742/2/rosane_teles_etal_IOC-2013.pdfbcc2c76b350dc3f946ed855def367266MD52TEXTrosane_teles_etal_IOC-2013.pdf.txtrosane_teles_etal_IOC-2013.pdf.txtExtracted texttext/plain44784https://www.arca.fiocruz.br/bitstream/icict/11742/3/rosane_teles_etal_IOC-2013.pdf.txtf4c58b963f1e401357071de8e9c1f784MD53icict/117422022-06-24 13:02:48.486oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:02:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes |
| title |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes |
| spellingShingle |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes Chung, Andrew W. Human Bacterial infection Galectin-3 Monocytes/macrophages; TLR2 nfecções Bacterianas Monócitos Macrófagos Humanos |
| title_short |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes |
| title_full |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes |
| title_fullStr |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes |
| title_full_unstemmed |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes |
| title_sort |
Galectin-3 Regulates the Innate Immune Response of Human Monocytes |
| author |
Chung, Andrew W. |
| author_facet |
Chung, Andrew W. Sieling, Peter A. Schenk, Mirjam Teles, Rosane M. B. Krutzik, Stephan R. Hsu, Daniel K. Liu, Fu-Tong Sarno, Euzenir N. Rea, Thomas H. Stenger, Steffen Modlin, Robert L. Lee, Delphine J. |
| author_role |
author |
| author2 |
Sieling, Peter A. Schenk, Mirjam Teles, Rosane M. B. Krutzik, Stephan R. Hsu, Daniel K. Liu, Fu-Tong Sarno, Euzenir N. Rea, Thomas H. Stenger, Steffen Modlin, Robert L. Lee, Delphine J. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Chung, Andrew W. Sieling, Peter A. Schenk, Mirjam Teles, Rosane M. B. Krutzik, Stephan R. Hsu, Daniel K. Liu, Fu-Tong Sarno, Euzenir N. Rea, Thomas H. Stenger, Steffen Modlin, Robert L. Lee, Delphine J. |
| dc.subject.en.pt_BR.fl_str_mv |
Human Bacterial infection Galectin-3 Monocytes/macrophages; TLR2 |
| topic |
Human Bacterial infection Galectin-3 Monocytes/macrophages; TLR2 nfecções Bacterianas Monócitos Macrófagos Humanos |
| dc.subject.decs.pt_BR.fl_str_mv |
nfecções Bacterianas Monócitos Macrófagos Humanos |
| description |
John Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA. |
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2013 |
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2013 |
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2015-09-21T17:25:35Z |
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2015-09-21T17:25:35Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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CHUNG, Andrew W.; et al. Galectin-3 Regulates the Innate Immune Response of Human Monocytes. J. Infect Dis., v.207, n.6, p.947-956, 2013. |
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https://www.arca.fiocruz.br/handle/icict/11742 |
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0022-1899 1537-6613 |
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10.1093/infdis/jis920 |
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CHUNG, Andrew W.; et al. Galectin-3 Regulates the Innate Immune Response of Human Monocytes. J. Infect Dis., v.207, n.6, p.947-956, 2013. 0022-1899 1537-6613 10.1093/infdis/jis920 |
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Oxford University Press |
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