Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58455 https://doi.org/10.1016/j.bbadva.2022.100053 |
Resumo: | Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil. |
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Lemos, Débora S.Beckert, Helen C.Oliveira, Luana C.Berti, Fernanda C. B.Ozawa, Patricia M.M.Souza, Ingrid L.M.Zanata, Silvio M.Pankievicz, Vânia C.S.Tuleski, Thalita R.Souza, Emanuel M.Silva, Rosiane V.Wowk, Pryscilla F.Petzl-Erler, Maria LuizaAlmeida, Rodrigo C.Cipolla, Gabriel AdelmanBoldt, Angelica B.W.Malheiros, Danielle2023-05-17T12:49:45Z2023-05-17T12:49:45Z2022LEMOS, Débora S. et al. Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals. BBA Advanced, v. 2, p. 1-10, 2022.https://www.arca.fiocruz.br/handle/icict/58455https://doi.org/10.1016/j.bbadva.2022.100053porElsevierExtracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Biologia Celular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Biologia Celular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Department of Biomedical Data Sciences. Molecular Epidemiology. Leiden University Medical Center. Leiden, The Netherlands.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Celiac disease (CD) is an autoimmune disorder triggered by an abnormal immunological response to gluten ingestion and is associated with deregulated expression of cellular microRNAs (miRNAs) of the gut mucosa. It is frequently misdiagnosed as lactose intolerance (LI) due to symptom resemblance. Microvilli loss may be counteracted by a rigorous gluten-free diet (GFD). Aims: To identify altered extracellular vesicle miRNAs from plasma among CD patients on GFD (n=34), lactose intolerant individuals on restrictive diet (n=14) and controls (n=23), and to predict biological pathways in which these altered miRNAs may play a part. Methods: Five different small RNA samples of each group were pooled twice and then screened by new-generation sequencing. Four miRNAs were selected to be quantified by RT-qPCR in the entire sample. Results: The levels of four miRNAs – miR-99b-3p, miR-197-3p, miR-223-3p, and miR-374b-5p – differed between CD patients and controls (P<0.05). Apart from miR-223-3p, all these miRNAs tended to have altered levels also between LI and controls (P<0.10). The results for miR-99b-3p and miR-197-3p between CD and controls were confirmed by RT-qPCR, which also indicated different levels of miR-99b-3p and miR-374b-5p between CD-associated LI and LI(P<0.05). Conclusions: These miRNAs may have targets that affect cell death, cell communication, adhesion, and inflammation modulation pathways. Hence, altered miRNA levels could be associated with CD-related aspects and gut mucosa recovery.Celiac DiseaseLactose IntoleranceExtracellular VesiclesMicroRNAsDiet, Gluten-FreeEnfermedad CelíacaIntolerancia a la LactosaVesículas ExtracelularesMicroARNsDieta Sin GlutenMaladie coeliaqueIntolérance au lactoseVésicules extracellulairesmicroARNRégime sans glutenDoença CelíacaIntolerância à LactoseVesículas ExtracelularesMicroRNAsDieta Livre de Glúteninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58455/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBBA_Advances-ExtracelularOK.pdfBBA_Advances-ExtracelularOK.pdfapplication/pdf2526077https://www.arca.fiocruz.br/bitstream/icict/58455/2/BBA_Advances-ExtracelularOK.pdfffc1e9c81290a457fb47c34063afa15bMD52icict/584552023-05-17 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dc.title.en_US.fl_str_mv |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals |
title |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals |
spellingShingle |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals Lemos, Débora S. Celiac Disease Lactose Intolerance Extracellular Vesicles MicroRNAs Diet, Gluten-Free Enfermedad Celíaca Intolerancia a la Lactosa Vesículas Extracelulares MicroARNs Dieta Sin Gluten Maladie coeliaque Intolérance au lactose Vésicules extracellulaires microARN Régime sans gluten Doença Celíaca Intolerância à Lactose Vesículas Extracelulares MicroRNAs Dieta Livre de Glúten |
title_short |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals |
title_full |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals |
title_fullStr |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals |
title_full_unstemmed |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals |
title_sort |
Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals |
author |
Lemos, Débora S. |
author_facet |
Lemos, Débora S. Beckert, Helen C. Oliveira, Luana C. Berti, Fernanda C. B. Ozawa, Patricia M.M. Souza, Ingrid L.M. Zanata, Silvio M. Pankievicz, Vânia C.S. Tuleski, Thalita R. Souza, Emanuel M. Silva, Rosiane V. Wowk, Pryscilla F. Petzl-Erler, Maria Luiza Almeida, Rodrigo C. Cipolla, Gabriel Adelman Boldt, Angelica B.W. Malheiros, Danielle |
author_role |
author |
author2 |
Beckert, Helen C. Oliveira, Luana C. Berti, Fernanda C. B. Ozawa, Patricia M.M. Souza, Ingrid L.M. Zanata, Silvio M. Pankievicz, Vânia C.S. Tuleski, Thalita R. Souza, Emanuel M. Silva, Rosiane V. Wowk, Pryscilla F. Petzl-Erler, Maria Luiza Almeida, Rodrigo C. Cipolla, Gabriel Adelman Boldt, Angelica B.W. Malheiros, Danielle |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lemos, Débora S. Beckert, Helen C. Oliveira, Luana C. Berti, Fernanda C. B. Ozawa, Patricia M.M. Souza, Ingrid L.M. Zanata, Silvio M. Pankievicz, Vânia C.S. Tuleski, Thalita R. Souza, Emanuel M. Silva, Rosiane V. Wowk, Pryscilla F. Petzl-Erler, Maria Luiza Almeida, Rodrigo C. Cipolla, Gabriel Adelman Boldt, Angelica B.W. Malheiros, Danielle |
dc.subject.en.en_US.fl_str_mv |
Celiac Disease |
topic |
Celiac Disease Lactose Intolerance Extracellular Vesicles MicroRNAs Diet, Gluten-Free Enfermedad Celíaca Intolerancia a la Lactosa Vesículas Extracelulares MicroARNs Dieta Sin Gluten Maladie coeliaque Intolérance au lactose Vésicules extracellulaires microARN Régime sans gluten Doença Celíaca Intolerância à Lactose Vesículas Extracelulares MicroRNAs Dieta Livre de Glúten |
dc.subject.en.En.fl_str_mv |
Lactose Intolerance Extracellular Vesicles MicroRNAs Diet, Gluten-Free |
dc.subject.es.en_US.fl_str_mv |
Enfermedad Celíaca |
dc.subject.es.es.fl_str_mv |
Intolerancia a la Lactosa |
dc.subject.es.Es.fl_str_mv |
Vesículas Extracelulares MicroARNs Dieta Sin Gluten |
dc.subject.fr.en_US.fl_str_mv |
Maladie coeliaque |
dc.subject.fr.Fr.fl_str_mv |
Intolérance au lactose Vésicules extracellulaires microARN Régime sans gluten |
dc.subject.decs.en_US.fl_str_mv |
Doença Celíaca |
dc.subject.decs.pt.fl_str_mv |
Intolerância à Lactose |
dc.subject.decs.Pt.fl_str_mv |
Vesículas Extracelulares MicroRNAs Dieta Livre de Glúten |
description |
Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-05-17T12:49:45Z |
dc.date.available.fl_str_mv |
2023-05-17T12:49:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
LEMOS, Débora S. et al. Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals. BBA Advanced, v. 2, p. 1-10, 2022. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/58455 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.bbadva.2022.100053 |
identifier_str_mv |
LEMOS, Débora S. et al. Extracellular vesicle microRNAs in celiac disease patients under a gluten-free diet, and in lactose intolerant individuals. BBA Advanced, v. 2, p. 1-10, 2022. |
url |
https://www.arca.fiocruz.br/handle/icict/58455 https://doi.org/10.1016/j.bbadva.2022.100053 |
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openAccess |
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Elsevier |
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Elsevier |
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