Transmitted drug resistance in patients with acute/recent HIV infection in Brazil

Detalhes bibliográficos
Autor(a) principal: Ferreira, Ana Cristina G.
Data de Publicação: 2017
Outros Autores: Coelho, Lara E., Grinsztejn, Eduarda, Jesus, Carlos S. de, Guimarães, Monick L., Veloso, Valdiléa G., Grinsztejn, Beatriz, Cardoso, Sandra W.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23456
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
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spelling Ferreira, Ana Cristina G.Coelho, Lara E.Grinsztejn, EduardaJesus, Carlos S. deGuimarães, Monick L.Veloso, Valdiléa G.Grinsztejn, BeatrizCardoso, Sandra W.2017-11-30T10:13:35Z2017-11-30T10:13:35Z2017FERREIRA, Ana Cristina G. et al. Transmitted drug resistance in patients with acute/recent HIV infection in Brazil. The Brazilian Journal of Infectious Diseases, v. 21, n. 4, p. 396-401, 2017.1413-8670https://www.arca.fiocruz.br/handle/icict/2345610.1016/j.bjid.2017.03.0131678-4391engElsevierHIVInfecçãoTransmissãoTerapia AntiretroviraisResistência primáriaHIVInfectionTransmissionPrimary resistanceAntiretroviral therapyTransmitted drug resistance in patients with acute/recent HIV infection in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Introduction: The widespread use of antiretroviral therapy increased the transmission of antiretroviral resistant HIV strains. Antiretroviral therapy initiation during acute/recent HIV infection limits HIV reservoirs and improves immune response in HIV infected individuals. Transmitted drug resistance may jeopardize the early goals of early antiretroviral treatment among acute/recent HIV infected patients. Methods: Patients with acute/recent HIV infection who underwent resistance test before antiretroviral treatment initiation were included in this analysis. HIV-1 sequences were obtained using an in house protease/reverse transcriptase genotyping assay. Transmitted drug resistance was identified according to the Stanford HIV Database for Transmitted Drug Resistance Mutations, based on WHO 2009 surveillance list, and HIV-1 subtyping according to Rega HIV-1 subtyping tool. Comparison between patients with and without transmitted drug resistance was made using Kruskal-Wallis and Chi-square tests. Results: Forty-three patients were included, 13 with acute HIV infection and 30 with recent HIV infection. The overall transmitted drug resistance prevalence was 16.3% (95% confidence interval [CI]: 8.1-30.0%). The highest prevalence of resistance (11.6%, 95% CI: 8.1-24.5) was against non-nucleoside reverse transcriptase inhibitors, and K103N was the most frequently identified mutation. Conclusions: The high prevalence of nonnucleoside reverse transcriptase inhibitors resistance indicates that efavirenz-based regimen without prior resistance testing is not ideal for acutely/recently HIV-infected individuals in our setting. In this context, the recent proposal of including integrase inhibitors as a first line regimen in Brazil could be an advantage for the treatment of newly HIV infected individuals. However, it also poses a new challenge, since integrase resistance test is not routinely performed for antiretroviral naive individuals. Further studies on transmitted drug resistance among acutely/recently HIV-infected are needed to inform the predictors of transmitted resistance and the antiretroviral therapy outcomes among these population.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23456/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmonick2_guimaraes_etal_IOC_2017.pdfmonick2_guimaraes_etal_IOC_2017.pdfapplication/pdf735914https://www.arca.fiocruz.br/bitstream/icict/23456/2/monick2_guimaraes_etal_IOC_2017.pdfadce48d8cd38bcd3ac90e76da891becbMD52TEXTmonick2_guimaraes_etal_IOC_2017.pdf.txtmonick2_guimaraes_etal_IOC_2017.pdf.txtExtracted texttext/plain27790https://www.arca.fiocruz.br/bitstream/icict/23456/3/monick2_guimaraes_etal_IOC_2017.pdf.txtf18157a5a3f881ac4840c0aa6487d790MD53icict/234562023-09-04 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dc.title.pt_BR.fl_str_mv Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
title Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
spellingShingle Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
Ferreira, Ana Cristina G.
HIV
Infecção
Transmissão
Terapia Antiretrovirais
Resistência primária
HIV
Infection
Transmission
Primary resistance
Antiretroviral therapy
title_short Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
title_full Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
title_fullStr Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
title_full_unstemmed Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
title_sort Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
author Ferreira, Ana Cristina G.
author_facet Ferreira, Ana Cristina G.
Coelho, Lara E.
Grinsztejn, Eduarda
Jesus, Carlos S. de
Guimarães, Monick L.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Cardoso, Sandra W.
author_role author
author2 Coelho, Lara E.
Grinsztejn, Eduarda
Jesus, Carlos S. de
Guimarães, Monick L.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Cardoso, Sandra W.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Ana Cristina G.
Coelho, Lara E.
Grinsztejn, Eduarda
Jesus, Carlos S. de
Guimarães, Monick L.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Cardoso, Sandra W.
dc.subject.other.pt_BR.fl_str_mv HIV
Infecção
Transmissão
Terapia Antiretrovirais
Resistência primária
topic HIV
Infecção
Transmissão
Terapia Antiretrovirais
Resistência primária
HIV
Infection
Transmission
Primary resistance
Antiretroviral therapy
dc.subject.en.pt_BR.fl_str_mv HIV
Infection
Transmission
Primary resistance
Antiretroviral therapy
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-11-30T10:13:35Z
dc.date.available.fl_str_mv 2017-11-30T10:13:35Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Ana Cristina G. et al. Transmitted drug resistance in patients with acute/recent HIV infection in Brazil. The Brazilian Journal of Infectious Diseases, v. 21, n. 4, p. 396-401, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23456
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2017.03.013
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv FERREIRA, Ana Cristina G. et al. Transmitted drug resistance in patients with acute/recent HIV infection in Brazil. The Brazilian Journal of Infectious Diseases, v. 21, n. 4, p. 396-401, 2017.
1413-8670
10.1016/j.bjid.2017.03.013
1678-4391
url https://www.arca.fiocruz.br/handle/icict/23456
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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