Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy

Detalhes bibliográficos
Autor(a) principal: Pinheiro, Maisa Pessoa
Data de Publicação: 2022
Outros Autores: Guimarães, Ana Virgínia Frota, Furtado, Gilvan Pessoa, Lourenzoni, Marcos Roberto
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52262
Resumo: Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
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spelling Pinheiro, Maisa PessoaGuimarães, Ana Virgínia FrotaFurtado, Gilvan PessoaLourenzoni, Marcos Roberto2022-04-14T14:17:41Z2022-04-14T14:17:41Z2022PINHEIRO, M. P. et al. Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 48.https://www.arca.fiocruz.br/handle/icict/5226210.35259/isi.2022_52262Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.engFiocruz/Instituto de Tecnologia em ImunobiológicosL-asparaginaseImunogenicidadeProjeto RacionalL-asparaginaseImmunogenicityRational DesignHuman L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/52262/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALAnais6thISI2022_48.pdfAnais6thISI2022_48.pdfapplication/pdf164178https://www.arca.fiocruz.br/bitstream/icict/52262/2/Anais6thISI2022_48.pdf39783e9dbbd615800a24ca9c011f8a6eMD52icict/522622023-04-26 16:56:18.38oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-26T19:56:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
title Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
spellingShingle Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
Pinheiro, Maisa Pessoa
L-asparaginase
Imunogenicidade
Projeto Racional
L-asparaginase
Immunogenicity
Rational Design
title_short Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
title_full Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
title_fullStr Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
title_full_unstemmed Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
title_sort Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy
author Pinheiro, Maisa Pessoa
author_facet Pinheiro, Maisa Pessoa
Guimarães, Ana Virgínia Frota
Furtado, Gilvan Pessoa
Lourenzoni, Marcos Roberto
author_role author
author2 Guimarães, Ana Virgínia Frota
Furtado, Gilvan Pessoa
Lourenzoni, Marcos Roberto
author2_role author
author
author
dc.contributor.author.fl_str_mv Pinheiro, Maisa Pessoa
Guimarães, Ana Virgínia Frota
Furtado, Gilvan Pessoa
Lourenzoni, Marcos Roberto
dc.subject.other.pt_BR.fl_str_mv L-asparaginase
Imunogenicidade
Projeto Racional
topic L-asparaginase
Imunogenicidade
Projeto Racional
L-asparaginase
Immunogenicity
Rational Design
dc.subject.en.pt_BR.fl_str_mv L-asparaginase
Immunogenicity
Rational Design
description Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-04-14T14:17:41Z
dc.date.available.fl_str_mv 2022-04-14T14:17:41Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv PINHEIRO, M. P. et al. Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 48.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52262
dc.identifier.doi.none.fl_str_mv 10.35259/isi.2022_52262
identifier_str_mv PINHEIRO, M. P. et al. Human L-asparaginase engineering for improvement of catalytic activity and application in Acute Lymphoblastic Leukemia therapy. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 48.
10.35259/isi.2022_52262
url https://www.arca.fiocruz.br/handle/icict/52262
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52262/1/license.txt
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