Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17852 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil |
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Solcà, Manuela da SilvaAndrade, Bruno de BezerrilAbbehusen, Melissa Moura CostaTeixeira, Clarissa RomeroCunha, Antonio Ricardo KhouriValenzuela, Jesus GKamhawi, ShadenBozza, Patrícia TorresFraga, Deborah Bittencourt MothéBorges, Valeria MatosVeras, Patrícia Sampaio TavaresBrodskyn, Claudia Ida2017-02-17T17:54:55Z2017-02-17T17:54:55Z2016SOLCÀ, M. S. et al. Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis. Scientific Reports, v. 6, p. 32619, 2016.2045-2322https://www.arca.fiocruz.br/handle/icict/1785210.1038/srep32619engNature Publishing GroupBiomarcadoresLeishmaniose Visceral CaninaInflamaçãoAnimalCãesSalivaMoscaBiomarkersCanine Visceral LeishmaniasisInflammationAnimalsDogsSalivaFlyCirculating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Fiocruz Piauí. Teresina, PI, BrasilFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Twinbrook Parkway, Rockville, USA.National Institute of Allergy and Infectious Diseases. National Institutes of Health. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Twinbrook Parkway, Rockville, USA.Instituto Oswaldo Cruz. FIOCRUZ. Bio-Manguinhos. Laboratório de Imunofarmacologia. Rio de Janeiro, BrazilFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil / Departamento de Medicina Veterinária Preventiva e Produção Animal, Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia para Doenças Tropicais (INCT-DT). Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia para Doenças Tropicais (INCT-DT). Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (III-INCT). São Paulo, SP, BrasilClinical manifestations in canine visceral leishmaniasis (CVL) have not been clearly associated with immunological status or disease progression. We simultaneously assessed biomarkers of inflammation, immune activation, oxidative stress, and anti-sand fly saliva IgG concentrations in dog sera with different clinical manifestations to characterize a biosignature associated with CVL severity. In a cross-sectional exploratory study, a random population of 70 dogs from an endemic area in Brazil was classified according to CVL clinical severity and parasitological evaluation. A panel of biomarkers and anti-sand fly saliva IgG were measured in canine sera. Assessment of protein expression of profile biomarkers identified a distinct biosignature that could cluster separately animal groups with different clinical scores. Increasing severity scores were associated with a gradual decrease of LTB4 and PGE2, and a gradual increase in CXCL1 and CCL2. Discriminant analyses revealed that combined assessment of LTB4, PGE2 and CXCL1 was able to distinguish dogs with different clinical scores. Dogs with the highest clinical score values also exhibited high parasite loads and higher concentrations of anti-saliva antibodies. Our findings suggest CVL clinical severity is tightly associated with a distinct inflammatory profile hallmarked by a differential expression of circulating eicosanoids and chemokines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17852/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSolca MS Circulating biomarkers....pdfSolca MS Circulating biomarkers....pdfapplication/pdf971763https://www.arca.fiocruz.br/bitstream/icict/17852/2/Solca%20MS%20Circulating%20biomarkers....pdfae827a5885cce77d4c101da125077818MD52TEXTSolca MS Circulating biomarkers....pdf.txtSolca MS Circulating biomarkers....pdf.txtExtracted texttext/plain38329https://www.arca.fiocruz.br/bitstream/icict/17852/3/Solca%20MS%20Circulating%20biomarkers....pdf.txt86a93416d04508490405493ea5cba057MD53icict/178522023-03-15 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dc.title.pt_BR.fl_str_mv |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis |
title |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis |
spellingShingle |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis Solcà, Manuela da Silva Biomarcadores Leishmaniose Visceral Canina Inflamação Animal Cães Saliva Mosca Biomarkers Canine Visceral Leishmaniasis Inflammation Animals Dogs Saliva Fly |
title_short |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis |
title_full |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis |
title_fullStr |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis |
title_full_unstemmed |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis |
title_sort |
Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis |
author |
Solcà, Manuela da Silva |
author_facet |
Solcà, Manuela da Silva Andrade, Bruno de Bezerril Abbehusen, Melissa Moura Costa Teixeira, Clarissa Romero Cunha, Antonio Ricardo Khouri Valenzuela, Jesus G Kamhawi, Shaden Bozza, Patrícia Torres Fraga, Deborah Bittencourt Mothé Borges, Valeria Matos Veras, Patrícia Sampaio Tavares Brodskyn, Claudia Ida |
author_role |
author |
author2 |
Andrade, Bruno de Bezerril Abbehusen, Melissa Moura Costa Teixeira, Clarissa Romero Cunha, Antonio Ricardo Khouri Valenzuela, Jesus G Kamhawi, Shaden Bozza, Patrícia Torres Fraga, Deborah Bittencourt Mothé Borges, Valeria Matos Veras, Patrícia Sampaio Tavares Brodskyn, Claudia Ida |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Solcà, Manuela da Silva Andrade, Bruno de Bezerril Abbehusen, Melissa Moura Costa Teixeira, Clarissa Romero Cunha, Antonio Ricardo Khouri Valenzuela, Jesus G Kamhawi, Shaden Bozza, Patrícia Torres Fraga, Deborah Bittencourt Mothé Borges, Valeria Matos Veras, Patrícia Sampaio Tavares Brodskyn, Claudia Ida |
dc.subject.other.pt_BR.fl_str_mv |
Biomarcadores Leishmaniose Visceral Canina Inflamação Animal Cães Saliva Mosca |
topic |
Biomarcadores Leishmaniose Visceral Canina Inflamação Animal Cães Saliva Mosca Biomarkers Canine Visceral Leishmaniasis Inflammation Animals Dogs Saliva Fly |
dc.subject.en.pt_BR.fl_str_mv |
Biomarkers Canine Visceral Leishmaniasis Inflammation Animals Dogs Saliva Fly |
description |
Fundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-17T17:54:55Z |
dc.date.available.fl_str_mv |
2017-02-17T17:54:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOLCÀ, M. S. et al. Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis. Scientific Reports, v. 6, p. 32619, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17852 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/srep32619 |
identifier_str_mv |
SOLCÀ, M. S. et al. Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis. Scientific Reports, v. 6, p. 32619, 2016. 2045-2322 10.1038/srep32619 |
url |
https://www.arca.fiocruz.br/handle/icict/17852 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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