The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations

Detalhes bibliográficos
Autor(a) principal: Belinato, Thiago Affonso
Data de Publicação: 2015
Outros Autores: Vale, Denise
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13717
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.
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spelling Belinato, Thiago AffonsoVale, Denise2016-04-12T13:47:22Z2016-04-12T13:47:22Z2015BELINATO, Thiago Affonso; VALLE, Denise. The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations. Plos One, v.10, n.6, 19p, Jun. 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1371710.1371/journal.pone.0130719engPublic Library of ScienceThe Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM). Rio de Janeiro, RJ, Brasil.Several Aedes aegypti field populations are resistant to neurotoxic insecticides, mainly organophoshates and pyrethroids, which are extensively used as larvicides and adulticides, respectively. Diflubenzuron (DFB), a chitin synthesis inhibitor (CSI), was recently approved for use in drinking water, and is presently employed in Brazil for Ae. aegypti control, against populations resistant to the organophosphate temephos. However, tests of DFB efficacy against field Ae. aegypti populations are lacking. In addition, information regarding the dynamics of CSI resistance, and characterization of any potential fitness effects that may arise in conjunction with resistance are essential for new Ae. aegypti control strategies. Here, the efficacy of DFB was evaluated for two Brazilian Ae. aegypti populations known to be resistant to both temephos and the pyrethroid deltamethrin. Laboratory selection for DFB resistance was then performed over six or seven generations, using a fixed dose of insecticide that inhibited 80% of adult emergence in the first generation. The selection process was stopped when adult emergence in the diflubenzuron-treated groups was equivalent to that of the control groups, kept without insecticide. Diflubenzuron was effective against the two Ae. aegypti field populations evaluated, regardless of their resistance level to neurotoxic insecticides. However, only a few generations of DFB selection were sufficient to change the susceptible status of both populations to this compound. Several aspects of mosquito biology were affected in both selected populations, indicating that diflubenzuron resistance acquisition is associated with a fitness cost. We believe that these results can significantly contribute to the design of control strategies involving the use of insect growth regulators.Aedes aegyptiDiflubenzuronInhibitorAedesDiflubenzuronInibidorinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13717/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALthiago_belinato_etal_IOC_2016.pdfthiago_belinato_etal_IOC_2016.pdfapplication/pdf1369955https://www.arca.fiocruz.br/bitstream/icict/13717/2/thiago_belinato_etal_IOC_2016.pdfdfc424182b8cd646c28619d0ed7bb08cMD52TEXTthiago_belinato_etal_IOC_2016.pdf.txtthiago_belinato_etal_IOC_2016.pdf.txtExtracted texttext/plain56429https://www.arca.fiocruz.br/bitstream/icict/13717/3/thiago_belinato_etal_IOC_2016.pdf.txtd0619e4bfa15960fddbc2932922b8a77MD53icict/137172018-04-02 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dc.title.pt_BR.fl_str_mv The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
title The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
spellingShingle The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
Belinato, Thiago Affonso
Aedes aegypti
Diflubenzuron
Inhibitor
Aedes
Diflubenzuron
Inibidor
title_short The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
title_full The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
title_fullStr The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
title_full_unstemmed The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
title_sort The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations
author Belinato, Thiago Affonso
author_facet Belinato, Thiago Affonso
Vale, Denise
author_role author
author2 Vale, Denise
author2_role author
dc.contributor.author.fl_str_mv Belinato, Thiago Affonso
Vale, Denise
dc.subject.en.pt_BR.fl_str_mv Aedes aegypti
Diflubenzuron
Inhibitor
topic Aedes aegypti
Diflubenzuron
Inhibitor
Aedes
Diflubenzuron
Inibidor
dc.subject.decs.pt_BR.fl_str_mv Aedes
Diflubenzuron
Inibidor
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-12T13:47:22Z
dc.date.available.fl_str_mv 2016-04-12T13:47:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BELINATO, Thiago Affonso; VALLE, Denise. The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations. Plos One, v.10, n.6, 19p, Jun. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13717
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0130719
identifier_str_mv BELINATO, Thiago Affonso; VALLE, Denise. The Impact of Selection with Diflubenzuron, a Chitin Synthesis Inhibitor, on the Fitness of Two Brazilian Aedes aegypti Field Populations. Plos One, v.10, n.6, 19p, Jun. 2015.
1932-6203
10.1371/journal.pone.0130719
url https://www.arca.fiocruz.br/handle/icict/13717
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/13717/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/13717/2/thiago_belinato_etal_IOC_2016.pdf
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