Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7626 |
Resumo: | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil |
| id |
CRUZ_d84d2dec9b41667000641c9ba04b11bb |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/7626 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Giusta, Caroline JunqueiraGuerrero, Ana TerezaGalvão Filho, BrunoAndrade, Warrison Athanásio Coelho deSalgado, Ana Paula CarneiroCunha, Thiago MattarRopert, CatherineCampos, Marco Antônio da SilvaPenido, Marcus Luiz de OliveiraPreviato, Lúcia MendonçaPreviato, Jose OswaldoRitter, GerdCunha, Fernando QueirozGazzinelli, Ricardo Tostes2014-05-14T16:09:13Z2014-05-14T16:09:13Z2012JUNQUEIRA, Caroline et al. Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine. Plos One. 2012, vol.7, pp. e362451932-6203https://www.arca.fiocruz.br/handle/icict/762610.1371/journal.pone.0036245engPublic Library of ScienceTrypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, BrazilFundaçao Oswaldo Cruz. Instituto Cerrado Pantanal. Campo Grande, MT, BrazilFundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil,Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts. Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, United States of AmericaFundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, BrazilUniversidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto, SP, BrazilFundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, BrazilFundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, BrazilInstituto de Biofısica Carlos Chagas Filho. Centro de Ciencias da Saude. Universidade Federal do Rio de Janeiro. Rio de Janeiro, BrazilInstituto de Biofısica Carlos Chagas Filho. Centro de Ciencias da Saude. Universidade Federal do Rio de Janeiro. Rio de Janeiro, BrazilNew York Branch at Memorial Sloan–Kettering Cancer Center.Ludwig Institute for Cancer Research. New York, New York, United States of AmericaUniversidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto, SP, BrazilFundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts. Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, United States of AmericaImmunological adjuvants that induce T cell-mediate immunity (TCMI) with the least side effects are needed for the development of human vaccines. Glycoinositolphospholipids (GIPL) and CpGs oligodeoxynucleotides (CpG ODNs) derived from the protozoa parasite Trypanosoma cruzi induce potent pro-inflammatory reaction through activation of Toll-Like Receptor (TLR) 4 and TLR9, respectively. Here, using mouse models, we tested the T. cruzi derived TLR agonists as immunological adjuvants in an antitumor vaccine. For comparison, we used well-established TLR agonists, such as the bacterial derived monophosphoryl lipid A (MPL), lipopeptide (Pam3Cys), and CpG ODN. All tested TLR agonists were comparable to induce antibody responses, whereas significant differences were noticed in their ability to elicit CD4(+) T and CD8(+) T cell responses. In particular, both GIPLs (GTH, and GY) and CpG ODNs (B344, B297 and B128) derived from T. cruzi elicited interferon-gamma (IFN-gamma) production by CD4(+) T cells. On the other hand, the parasite derived CpG ODNs, but not GIPLs, elicited a potent IFN-gamma response by CD8(+) T lymphocytes. The side effects were also evaluated by local pain (hypernociception). The intensity of hypernociception induced by vaccination was alleviated by administration of an analgesic drug without affecting protective immunity. Finally, the level of protective immunity against the NY-ESO-1 expressing melanoma was associated with the magnitude of both CD4+ T and CD8+ T cell responses elicited by a specific immunological adjuvant.Trypanosoma cruziimmunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALTrypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.pdfTrypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.pdfapplication/pdf2941504https://www.arca.fiocruz.br/bitstream/icict/7626/1/Trypanosoma%20cruzi%20adjuvants%20potentiate%20T%20Cell-mediated%20immunity%20induced%20by%20a%20NY-ESO-1%20based%20antitumor%20vaccine.pdfe95f2649de594f3f9144c11a020a6095MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7626/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTTrypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.pdf.txtTrypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.pdf.txtExtracted texttext/plain13https://www.arca.fiocruz.br/bitstream/icict/7626/5/Trypanosoma%20cruzi%20adjuvants%20potentiate%20T%20Cell-mediated%20immunity%20induced%20by%20a%20NY-ESO-1%20based%20antitumor%20vaccine.pdf.txt67e866c735744ec6037b77b623ee022dMD55THUMBNAILTrypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.pdf.jpgTrypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.pdf.jpgGenerated Thumbnailimage/jpeg2386https://www.arca.fiocruz.br/bitstream/icict/7626/4/Trypanosoma%20cruzi%20adjuvants%20potentiate%20T%20Cell-mediated%20immunity%20induced%20by%20a%20NY-ESO-1%20based%20antitumor%20vaccine.pdf.jpg20f8c9d1e054b6af3785c734aabe2b81MD54icict/76262018-04-06 08:48:47.408oai:www.arca.fiocruz.br:icict/7626TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:48:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine |
| title |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine |
| spellingShingle |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine Giusta, Caroline Junqueira Trypanosoma cruzi immunology |
| title_short |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine |
| title_full |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine |
| title_fullStr |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine |
| title_full_unstemmed |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine |
| title_sort |
Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine |
| author |
Giusta, Caroline Junqueira |
| author_facet |
Giusta, Caroline Junqueira Guerrero, Ana Tereza Galvão Filho, Bruno Andrade, Warrison Athanásio Coelho de Salgado, Ana Paula Carneiro Cunha, Thiago Mattar Ropert, Catherine Campos, Marco Antônio da Silva Penido, Marcus Luiz de Oliveira Previato, Lúcia Mendonça Previato, Jose Oswaldo Ritter, Gerd Cunha, Fernando Queiroz Gazzinelli, Ricardo Tostes |
| author_role |
author |
| author2 |
Guerrero, Ana Tereza Galvão Filho, Bruno Andrade, Warrison Athanásio Coelho de Salgado, Ana Paula Carneiro Cunha, Thiago Mattar Ropert, Catherine Campos, Marco Antônio da Silva Penido, Marcus Luiz de Oliveira Previato, Lúcia Mendonça Previato, Jose Oswaldo Ritter, Gerd Cunha, Fernando Queiroz Gazzinelli, Ricardo Tostes |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Giusta, Caroline Junqueira Guerrero, Ana Tereza Galvão Filho, Bruno Andrade, Warrison Athanásio Coelho de Salgado, Ana Paula Carneiro Cunha, Thiago Mattar Ropert, Catherine Campos, Marco Antônio da Silva Penido, Marcus Luiz de Oliveira Previato, Lúcia Mendonça Previato, Jose Oswaldo Ritter, Gerd Cunha, Fernando Queiroz Gazzinelli, Ricardo Tostes |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi immunology |
| topic |
Trypanosoma cruzi immunology |
| description |
Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
| dc.date.accessioned.fl_str_mv |
2014-05-14T16:09:13Z |
| dc.date.available.fl_str_mv |
2014-05-14T16:09:13Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
JUNQUEIRA, Caroline et al. Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine. Plos One. 2012, vol.7, pp. e36245 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7626 |
| dc.identifier.issn.none.fl_str_mv |
1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0036245 |
| identifier_str_mv |
JUNQUEIRA, Caroline et al. Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine. Plos One. 2012, vol.7, pp. e36245 1932-6203 10.1371/journal.pone.0036245 |
| url |
https://www.arca.fiocruz.br/handle/icict/7626 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Public Library of Science |
| publisher.none.fl_str_mv |
Public Library of Science |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/7626/1/Trypanosoma%20cruzi%20adjuvants%20potentiate%20T%20Cell-mediated%20immunity%20induced%20by%20a%20NY-ESO-1%20based%20antitumor%20vaccine.pdf https://www.arca.fiocruz.br/bitstream/icict/7626/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/7626/5/Trypanosoma%20cruzi%20adjuvants%20potentiate%20T%20Cell-mediated%20immunity%20induced%20by%20a%20NY-ESO-1%20based%20antitumor%20vaccine.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/7626/4/Trypanosoma%20cruzi%20adjuvants%20potentiate%20T%20Cell-mediated%20immunity%20induced%20by%20a%20NY-ESO-1%20based%20antitumor%20vaccine.pdf.jpg |
| bitstream.checksum.fl_str_mv |
e95f2649de594f3f9144c11a020a6095 7d48279ffeed55da8dfe2f8e81f3b81f 67e866c735744ec6037b77b623ee022d 20f8c9d1e054b6af3785c734aabe2b81 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798325048368431104 |