Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42597 |
Resumo: | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil. |
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Chagas, Luana da SilvaSandre, Poliana CapuchoRibeiro, Natalia Cristina Aparecida Ribeiro eMarcondes, HenriqueSilva, Priscilla OliveiraSavino, WilsonSerfaty, Claudio A.2020-08-07T20:03:11Z2020-08-07T20:03:11Z2020CHAGAS, Luana da Silva et al. Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease. International Journal of Molecular Sciences, v. 21, n. 2111, p. 1-20, 2020.1661-6596https://www.arca.fiocruz.br/handle/icict/4259710.3390/ijms210621111422-0067engMDPINeuroinflamaçãoDesenvolvimento cerebralCross-talk de células imunesNeuroplasticidadeFatores ambientaisAtivação microglialNeuroinflammationBrain development;Immune cell cross-talkNeuroplasticityEnvironmental factorsMicroglial activationEnvironmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil.Recent discoveries on the neurobiology of the immunocompetent cells of the central nervous system (CNS), microglia, have been recognized as a growing field of investigation on the interactions between the brain and the immune system. Several environmental contexts such as stress, lesions, infectious diseases, and nutritional and hormonal disorders can interfere with CNS homeostasis, directly impacting microglial physiology. Despite many encouraging discoveries in this field, there are still some controversies that raise issues to be discussed, especially regarding the relationship between the microglial phenotype assumed in distinct contexts and respective consequences in different neurobiological processes, such as disorders of brain development and neuroplasticity. Also, there is an increasing interest in discussing microglial-immune system cross-talk in health and in pathological conditions. In this review, we discuss recent literature concerning microglial function during development and homeostasis. In addition, we explore the contribution of microglia to synaptic disorders mediated by different neuroinflammatory outcomes during pre- and postnatal development, with long-term consequences impacting on the risk and vulnerability to the emergence of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALWilsonSavino_PolyanaSandre_etal_IOC_2020.pdfWilsonSavino_PolyanaSandre_etal_IOC_2020.pdfapplication/pdf1747451https://www.arca.fiocruz.br/bitstream/icict/42597/2/WilsonSavino_PolyanaSandre_etal_IOC_2020.pdff4643bec22051adc604298ed05f599e2MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42597/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTWilsonSavino_PolyanaSandre_etal_IOC_2020.pdf.txtWilsonSavino_PolyanaSandre_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease |
title |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease |
spellingShingle |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease Chagas, Luana da Silva Neuroinflamação Desenvolvimento cerebral Cross-talk de células imunes Neuroplasticidade Fatores ambientais Ativação microglial Neuroinflammation Brain development; Immune cell cross-talk Neuroplasticity Environmental factors Microglial activation |
title_short |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease |
title_full |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease |
title_fullStr |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease |
title_full_unstemmed |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease |
title_sort |
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease |
author |
Chagas, Luana da Silva |
author_facet |
Chagas, Luana da Silva Sandre, Poliana Capucho Ribeiro, Natalia Cristina Aparecida Ribeiro e Marcondes, Henrique Silva, Priscilla Oliveira Savino, Wilson Serfaty, Claudio A. |
author_role |
author |
author2 |
Sandre, Poliana Capucho Ribeiro, Natalia Cristina Aparecida Ribeiro e Marcondes, Henrique Silva, Priscilla Oliveira Savino, Wilson Serfaty, Claudio A. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Chagas, Luana da Silva Sandre, Poliana Capucho Ribeiro, Natalia Cristina Aparecida Ribeiro e Marcondes, Henrique Silva, Priscilla Oliveira Savino, Wilson Serfaty, Claudio A. |
dc.subject.other.pt_BR.fl_str_mv |
Neuroinflamação Desenvolvimento cerebral Cross-talk de células imunes Neuroplasticidade Fatores ambientais Ativação microglial |
topic |
Neuroinflamação Desenvolvimento cerebral Cross-talk de células imunes Neuroplasticidade Fatores ambientais Ativação microglial Neuroinflammation Brain development; Immune cell cross-talk Neuroplasticity Environmental factors Microglial activation |
dc.subject.en.pt_BR.fl_str_mv |
Neuroinflammation Brain development; Immune cell cross-talk Neuroplasticity Environmental factors Microglial activation |
description |
Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-08-07T20:03:11Z |
dc.date.available.fl_str_mv |
2020-08-07T20:03:11Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CHAGAS, Luana da Silva et al. Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease. International Journal of Molecular Sciences, v. 21, n. 2111, p. 1-20, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/42597 |
dc.identifier.issn.pt_BR.fl_str_mv |
1661-6596 |
dc.identifier.doi.none.fl_str_mv |
10.3390/ijms21062111 |
dc.identifier.eissn.none.fl_str_mv |
1422-0067 |
identifier_str_mv |
CHAGAS, Luana da Silva et al. Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease. International Journal of Molecular Sciences, v. 21, n. 2111, p. 1-20, 2020. 1661-6596 10.3390/ijms21062111 1422-0067 |
url |
https://www.arca.fiocruz.br/handle/icict/42597 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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