Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease

Detalhes bibliográficos
Autor(a) principal: Chagas, Luana da Silva
Data de Publicação: 2020
Outros Autores: Sandre, Poliana Capucho, Ribeiro, Natalia Cristina Aparecida Ribeiro e, Marcondes, Henrique, Silva, Priscilla Oliveira, Savino, Wilson, Serfaty, Claudio A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42597
Resumo: Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.
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spelling Chagas, Luana da SilvaSandre, Poliana CapuchoRibeiro, Natalia Cristina Aparecida Ribeiro eMarcondes, HenriqueSilva, Priscilla OliveiraSavino, WilsonSerfaty, Claudio A.2020-08-07T20:03:11Z2020-08-07T20:03:11Z2020CHAGAS, Luana da Silva et al. Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease. International Journal of Molecular Sciences, v. 21, n. 2111, p. 1-20, 2020.1661-6596https://www.arca.fiocruz.br/handle/icict/4259710.3390/ijms210621111422-0067engMDPINeuroinflamaçãoDesenvolvimento cerebralCross-talk de células imunesNeuroplasticidadeFatores ambientaisAtivação microglialNeuroinflammationBrain development;Immune cell cross-talkNeuroplasticityEnvironmental factorsMicroglial activationEnvironmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil.Recent discoveries on the neurobiology of the immunocompetent cells of the central nervous system (CNS), microglia, have been recognized as a growing field of investigation on the interactions between the brain and the immune system. Several environmental contexts such as stress, lesions, infectious diseases, and nutritional and hormonal disorders can interfere with CNS homeostasis, directly impacting microglial physiology. Despite many encouraging discoveries in this field, there are still some controversies that raise issues to be discussed, especially regarding the relationship between the microglial phenotype assumed in distinct contexts and respective consequences in different neurobiological processes, such as disorders of brain development and neuroplasticity. Also, there is an increasing interest in discussing microglial-immune system cross-talk in health and in pathological conditions. In this review, we discuss recent literature concerning microglial function during development and homeostasis. In addition, we explore the contribution of microglia to synaptic disorders mediated by different neuroinflammatory outcomes during pre- and postnatal development, with long-term consequences impacting on the risk and vulnerability to the emergence of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALWilsonSavino_PolyanaSandre_etal_IOC_2020.pdfWilsonSavino_PolyanaSandre_etal_IOC_2020.pdfapplication/pdf1747451https://www.arca.fiocruz.br/bitstream/icict/42597/2/WilsonSavino_PolyanaSandre_etal_IOC_2020.pdff4643bec22051adc604298ed05f599e2MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42597/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTWilsonSavino_PolyanaSandre_etal_IOC_2020.pdf.txtWilsonSavino_PolyanaSandre_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
title Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
spellingShingle Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
Chagas, Luana da Silva
Neuroinflamação
Desenvolvimento cerebral
Cross-talk de células imunes
Neuroplasticidade
Fatores ambientais
Ativação microglial
Neuroinflammation
Brain development;
Immune cell cross-talk
Neuroplasticity
Environmental factors
Microglial activation
title_short Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
title_full Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
title_fullStr Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
title_full_unstemmed Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
title_sort Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
author Chagas, Luana da Silva
author_facet Chagas, Luana da Silva
Sandre, Poliana Capucho
Ribeiro, Natalia Cristina Aparecida Ribeiro e
Marcondes, Henrique
Silva, Priscilla Oliveira
Savino, Wilson
Serfaty, Claudio A.
author_role author
author2 Sandre, Poliana Capucho
Ribeiro, Natalia Cristina Aparecida Ribeiro e
Marcondes, Henrique
Silva, Priscilla Oliveira
Savino, Wilson
Serfaty, Claudio A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chagas, Luana da Silva
Sandre, Poliana Capucho
Ribeiro, Natalia Cristina Aparecida Ribeiro e
Marcondes, Henrique
Silva, Priscilla Oliveira
Savino, Wilson
Serfaty, Claudio A.
dc.subject.other.pt_BR.fl_str_mv Neuroinflamação
Desenvolvimento cerebral
Cross-talk de células imunes
Neuroplasticidade
Fatores ambientais
Ativação microglial
topic Neuroinflamação
Desenvolvimento cerebral
Cross-talk de células imunes
Neuroplasticidade
Fatores ambientais
Ativação microglial
Neuroinflammation
Brain development;
Immune cell cross-talk
Neuroplasticity
Environmental factors
Microglial activation
dc.subject.en.pt_BR.fl_str_mv Neuroinflammation
Brain development;
Immune cell cross-talk
Neuroplasticity
Environmental factors
Microglial activation
description Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-07T20:03:11Z
dc.date.available.fl_str_mv 2020-08-07T20:03:11Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAGAS, Luana da Silva et al. Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease. International Journal of Molecular Sciences, v. 21, n. 2111, p. 1-20, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42597
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.none.fl_str_mv 10.3390/ijms21062111
dc.identifier.eissn.none.fl_str_mv 1422-0067
identifier_str_mv CHAGAS, Luana da Silva et al. Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease. International Journal of Molecular Sciences, v. 21, n. 2111, p. 1-20, 2020.
1661-6596
10.3390/ijms21062111
1422-0067
url https://www.arca.fiocruz.br/handle/icict/42597
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/42597/2/WilsonSavino_PolyanaSandre_etal_IOC_2020.pdf
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https://www.arca.fiocruz.br/bitstream/icict/42597/4/WilsonSavino_PolyanaSandre_etal_IOC_2020.pdf.txt
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