Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil

Detalhes bibliográficos
Autor(a) principal: Carvalho, Marilia Sá
Data de Publicação: 2020
Outros Autores: Freitas, Laís Picinini, Cruz, Oswaldo Gonçalves, Brasil, Patrícia, Bastos, Leonardo Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39805
Resumo: Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
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spelling Carvalho, Marilia SáFreitas, Laís PicininiCruz, Oswaldo GonçalvesBrasil, PatríciaBastos, Leonardo Soares2020-02-07T17:38:24Z2020-02-07T17:38:24Z2020CARVALHO, Marília Sá et al. Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil. Scientific Reports, v. 10, n. 1752, p. 1-9, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/3980510.1038/s41598-020-58407-72045-2322engNature ReseachEpidemiologiaVirosesEpidemiologyViral InfectionEpidemiologyVirus Diseases Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Programa de Pós-Graduação em Epidemiologia em Saúde Pública. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Despite all the research done on the first Zika virus (ZIKV) epidemics, it was only after the Brazilian epidemic that the Congenital Zika Syndrome was described. This was made possible due to the large number of babies born with microcephaly in the Northeast region (NE) in a narrow time. We hypothesize that the fivefold difference in the rate of microcephalic neonates between the NE and other regions is partially an effect of the population prior immunity against Dengue viruses (DENV), that cross-react with ZIKV. In this ecological study, we analysed the interaction between dengue fever epidemics from 2001 to 2014 and the 2015/2016 microcephaly epidemic in 400 microregions in Brazil using random-effects models under a Bayesian approach. The estimated effect of the time lag between the most recent large dengue epidemic (>400/100,000 inhabitants) and the microcephaly epidemic ranged from protection (up to 6 years prior) to an increased risk (from 7 to 12 years). This sustained window of protection, larger than described in previous longitudinal studies, is possibly an effect of herd immunity and of multiple exposures to DENV that could boost immunity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39805/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAssociationDengueFever.pdfAssociationDengueFever.pdfapplication/pdf2120471https://www.arca.fiocruz.br/bitstream/icict/39805/2/AssociationDengueFever.pdf37f2b4f22cdfe2b706ba34952238046eMD52TEXTAssociationDengueFever.pdf.txtAssociationDengueFever.pdf.txtExtracted texttext/plain35423https://www.arca.fiocruz.br/bitstream/icict/39805/3/AssociationDengueFever.pdf.txt4084450efe8294df6abb25fc5adf8316MD53icict/398052020-02-10 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dc.title.pt_BR.fl_str_mv Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
title Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
spellingShingle Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
Carvalho, Marilia Sá
Epidemiologia
Viroses
Epidemiology
Viral Infection
Epidemiology
Virus Diseases 
title_short Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
title_full Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
title_fullStr Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
title_full_unstemmed Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
title_sort Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil
author Carvalho, Marilia Sá
author_facet Carvalho, Marilia Sá
Freitas, Laís Picinini
Cruz, Oswaldo Gonçalves
Brasil, Patrícia
Bastos, Leonardo Soares
author_role author
author2 Freitas, Laís Picinini
Cruz, Oswaldo Gonçalves
Brasil, Patrícia
Bastos, Leonardo Soares
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Marilia Sá
Freitas, Laís Picinini
Cruz, Oswaldo Gonçalves
Brasil, Patrícia
Bastos, Leonardo Soares
dc.subject.other.pt_BR.fl_str_mv Epidemiologia
Viroses
topic Epidemiologia
Viroses
Epidemiology
Viral Infection
Epidemiology
Virus Diseases 
dc.subject.en.pt_BR.fl_str_mv Epidemiology
Viral Infection
dc.subject.decs.pt_BR.fl_str_mv Epidemiology
Virus Diseases 
description Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-02-07T17:38:24Z
dc.date.available.fl_str_mv 2020-02-07T17:38:24Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Marília Sá et al. Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil. Scientific Reports, v. 10, n. 1752, p. 1-9, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39805
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-020-58407-7
dc.identifier.eissn.none.fl_str_mv 2045-2322
identifier_str_mv CARVALHO, Marília Sá et al. Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil. Scientific Reports, v. 10, n. 1752, p. 1-9, 2020.
2045-2322
10.1038/s41598-020-58407-7
url https://www.arca.fiocruz.br/handle/icict/39805
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Reseach
publisher.none.fl_str_mv Nature Reseach
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/39805/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/39805/2/AssociationDengueFever.pdf
https://www.arca.fiocruz.br/bitstream/icict/39805/3/AssociationDengueFever.pdf.txt
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