Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43078 |
Resumo: | FAPESP grants #2012/16525-2 and #2017/18611-7. JCKS receives a scholarship from CAPES. JLSF receives a scholarship from FAPESP #2916/12855-9. HN, MVGL, EVP and FTMC are CNPq research fellows. |
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Santos, João Conrado Khouri dosSilva Filho, João LuizJudice, Carla CKayano, Ana Carolina Andrade VitorAliberti, JúlioCunha, Antonio Ricardo KhouriLima, Diógenes S. deNakaya, HelderLacerda, Marcus Vinicius GuimarãesPaula, Erich Vinicius deLopes, Stefanie Costa PintoCosta, Fabio Trindade Maranhão2020-08-31T14:33:54Z2020-08-31T14:33:54Z2020SANTOS, João Conrado Khouri dos et al. Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. LoS Neglected Tropical Diseases, 2020.https://www.arca.fiocruz.br/handle/icict/43078FAPESP grants #2012/16525-2 and #2017/18611-7. JCKS receives a scholarship from CAPES. JLSF receives a scholarship from FAPESP #2916/12855-9. HN, MVGL, EVP and FTMC are CNPq research fellows.Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Doenças Tropicais Prof. Luiz Jacintho da Silva. Campinas, SP, Brasil / Universidade Estadual de Campinas Faculdade de Ciências Médicas.Campinas, SP, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Doenças Tropicais Prof. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Doenças Tropicais Prof. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Doenças Tropicais Prof. Luiz Jacintho da Silva. Campinas, SP, Brasil.National Institute of Allergy and Infectious Diseases. Maryland, USA.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.University of Sao Paulo. School of Pharmaceutical Sciences. Department of Clinical and Toxicological Analyses. São Paulo, SP, Brazil..Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil..Universidade Estadual de Campinas. Centro de Hematologia e Hemoterapia. Hemocentro. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil..Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Doenças Tropicais Prof. Luiz Jacintho da Silva. Campinas, SP, Brasil.Platelets drive endothelial cell activation in many diseases. However, if this occurs in Plasmodium vivax malaria is unclear. As platelets have been reported to be activated and to play a role in inflammatory response during malaria, we hypothesized that this would correlate with endothelial alterations during acute illness. Methods. We performed platelet flow cytometry of PAC-1 and P-selectin. We measured Platelet markers (CXCL4, CD40L, P-selectin, Thrombopoietin, IL-11) and endothelial markers (ICAM-1, von Willebrand Factor and E-selectin) in plasma with a multiplex-based assay. The values of each mediator were used to generate heatmaps, K-means clustering and Principal Component analysis. In addition, we determined pair-wise Pearson’s correlation coefficients to generate correlation networks. Results. Platelet counts were reduced, and mean platelet volume increased in malaria patients. The activation of circulating platelets in flow cytometry did not differ between patients and controls. CD40L levels (Median [IQ]: 517 [406-651] vs. 1029 [732- 1267] pg/mL, P=0.0001) were significantly higher in patients, while P-selectin (Median [IQ]: 17.0 [15.4-20.6] vs. 22.2 [17.6-25.7] ng/mL, P=0.0621) and CXCL4 showed a nonsignificant trend towards higher levels in patients. The network correlation approach demonstrated the correlation between markers of platelet and endothelial activation, and the heatmaps revealed a distinct pattern of activation in two subsets of P. vivax patients when compared to controls. Conclusion. platelet activation occurs in uncomplicated vivax malaria and this correlates with higher endothelial cell activation, especially in a subset of patients.engPublic Library of ScienceTrombocitopeniaTrombopoieseAtivação plaquetáriaCD40LAtivação de células endoteliaisThrombocytopeniaThrombopoiesisPlatelet activationCD40LP-selectinEndothelial cell activation.Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43078/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos, Joao Conrado Khouri dos Platelet disturbances....pdfSantos, Joao Conrado Khouri dos Platelet 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dc.title.pt_BR.fl_str_mv |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria |
title |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria |
spellingShingle |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria Santos, João Conrado Khouri dos Trombocitopenia Trombopoiese Ativação plaquetária CD40L Ativação de células endoteliais Thrombocytopenia Thrombopoiesis Platelet activation CD40L P-selectin Endothelial cell activation. |
title_short |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria |
title_full |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria |
title_fullStr |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria |
title_full_unstemmed |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria |
title_sort |
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria |
author |
Santos, João Conrado Khouri dos |
author_facet |
Santos, João Conrado Khouri dos Silva Filho, João Luiz Judice, Carla C Kayano, Ana Carolina Andrade Vitor Aliberti, Júlio Cunha, Antonio Ricardo Khouri Lima, Diógenes S. de Nakaya, Helder Lacerda, Marcus Vinicius Guimarães Paula, Erich Vinicius de Lopes, Stefanie Costa Pinto Costa, Fabio Trindade Maranhão |
author_role |
author |
author2 |
Silva Filho, João Luiz Judice, Carla C Kayano, Ana Carolina Andrade Vitor Aliberti, Júlio Cunha, Antonio Ricardo Khouri Lima, Diógenes S. de Nakaya, Helder Lacerda, Marcus Vinicius Guimarães Paula, Erich Vinicius de Lopes, Stefanie Costa Pinto Costa, Fabio Trindade Maranhão |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, João Conrado Khouri dos Silva Filho, João Luiz Judice, Carla C Kayano, Ana Carolina Andrade Vitor Aliberti, Júlio Cunha, Antonio Ricardo Khouri Lima, Diógenes S. de Nakaya, Helder Lacerda, Marcus Vinicius Guimarães Paula, Erich Vinicius de Lopes, Stefanie Costa Pinto Costa, Fabio Trindade Maranhão |
dc.subject.other.pt_BR.fl_str_mv |
Trombocitopenia Trombopoiese Ativação plaquetária CD40L Ativação de células endoteliais |
topic |
Trombocitopenia Trombopoiese Ativação plaquetária CD40L Ativação de células endoteliais Thrombocytopenia Thrombopoiesis Platelet activation CD40L P-selectin Endothelial cell activation. |
dc.subject.en.pt_BR.fl_str_mv |
Thrombocytopenia Thrombopoiesis Platelet activation CD40L P-selectin Endothelial cell activation. |
description |
FAPESP grants #2012/16525-2 and #2017/18611-7. JCKS receives a scholarship from CAPES. JLSF receives a scholarship from FAPESP #2916/12855-9. HN, MVGL, EVP and FTMC are CNPq research fellows. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-08-31T14:33:54Z |
dc.date.available.fl_str_mv |
2020-08-31T14:33:54Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, João Conrado Khouri dos et al. Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. LoS Neglected Tropical Diseases, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/43078 |
identifier_str_mv |
SANTOS, João Conrado Khouri dos et al. Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. LoS Neglected Tropical Diseases, 2020. |
url |
https://www.arca.fiocruz.br/handle/icict/43078 |
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eng |
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eng |
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Public Library of Science |
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Public Library of Science |
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