Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB

Detalhes bibliográficos
Autor(a) principal: Luetkemeyer, Anne F.
Data de Publicação: 2014
Outros Autores: Kendall, Michelle A., Wu, Xingye, Lourenço, Maria Cristina, Jentsch, Ute, Swindells, Susan, Qasba, Sarojini S., Sanchez, Jorge, Havlir, Diane V., Grinsztejn, Beatriz, Sanne, Ian M., Firnhaber, Cynthia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11182
Resumo: This work was supported by award number U01AI068636 from the National Institute of Allergy and Infectious Diseases and the Statistical and Data Management Center (SDMC) (UM1 AI068634) funded by the National Institute of Allergy and Infectious Diseases. A.F.L. reports research grant support to the University of California, San Francisco, from Cepheid.
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spelling Luetkemeyer, Anne F.Kendall, Michelle A.Wu, XingyeLourenço, Maria CristinaJentsch, UteSwindells, SusanQasba, Sarojini S.Sanchez, JorgeHavlir, Diane V.Grinsztejn, BeatrizSanne, Ian M.Firnhaber, Cynthia2015-07-09T12:18:42Z2015-07-09T12:18:42Z2014LUETKEMEYER, Anne F. et al. Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB. Journal of Clinical Microbiology, v.52, n.4, p.1052-1059, 2014.0095-1137https://www.arca.fiocruz.br/handle/icict/1118210.1128/JCM.02639-131098-660XThis work was supported by award number U01AI068636 from the National Institute of Allergy and Infectious Diseases and the Statistical and Data Management Center (SDMC) (UM1 AI068634) funded by the National Institute of Allergy and Infectious Diseases. A.F.L. reports research grant support to the University of California, San Francisco, from Cepheid.University of California. San Francisco General Hospital. HIV/AIDS Division. San Francisco, CA, United States of AmericaHarvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, United States of AmericaHarvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, United States of AmericaFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilUniversity of the Witwatersrand. Clinical Laboratory Services and School of Pathology. Johannesburg, South AfricaUniversity of Nebraska Medical Center. Division of Infectious Diseases. Omaha, NE, United States of AmericaMontgomery County Health Department. Silver Spring, MD, United States of AmericaAsociación Civil Impacta Salud y Educación. Lima, PeruUniversity of California. San Francisco General Hospital. HIV/AIDS Division. San Francisco, CA, United States of AmericaFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilUniversity of the Witwatersrand. Johannesburg. Faculty of Health Sciences. Clinical HIV Research Unit. South Africah / Right to Care. Johannesburg, South AfricaUniversity of the Witwatersrand. Johannesburg. Faculty of Health Sciences. Clinical HIV Research Unit. South Africah / Right to Care. Johannesburg, South AfricaLimited performance data from line probe assays (LPAs), nucleic acid tests used for the rapid diagnosis of tuberculosis (TB), nontuberculosis mycobacteria (NTM), and Mycobacterium tuberculosis drug resistance are available for HIV-infected individuals, in whom paucibacillary TB is common. In this study, the strategy of testing sputum with GenoType MTBDRplus (MTBDR-Plus) and GenoType Direct LPA (Direct LPA) was compared to a gold standard of one mycobacterial growth indicator tube (MGIT) liquid culture. HIV-positive (HIV+) individuals with suspected TB from southern Africa and South America with <7 days of TB treatment had 1 sputum specimen tested with Direct LPA, MTBDR-Plus LPA, smear microscopy, MGIT, biochemical identification of mycobacterial species, and culture-based drug-susceptibility testing (DST). Of 639 participants, 59.3% were MGIT M. tuberculosis culture positive, of which 276 (72.8%) were acid-fast bacillus (AFB) smear positive. MTBDR-Plus had a sensitivity of 81.0% and a specificity of 100%, with sensitivities of 44.1% in AFB smear-negative versus 94.6% in AFB smear-positive specimens. For specimens that were positive for M. tuberculosis by MTBDR-Plus, the sensitivity and specificity for rifampin resistance were 91.7% and 96.6%, respectively, and for isoniazid (INH) they were 70.6% and 99.1%. The Direct LPA had a sensitivity of 88.4% and a specificity of 94.6% for M. tuberculosis detection, with a sensitivity of 72.5% in smear-negative specimens. Ten of 639 MGIT cultures grew Mycobacterium avium complex or Mycobacterium kansasii, half of which were detected by Direct LPA. Both LPA assays performed well in specimens from HIV-infected individuals, including in AFB smear-negative specimens, with 72.5% sensitivity for M. tuberculosis identification with the Direct LPA and 44.1% sensitivity with MTBDR-Plus. LPAs have a continued role for use in settings where rapid identification of INH resistance and clinically relevant NTM are priorities.engAmerican Society for MicrobiologyEvaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TBinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTuberculosisHIVDrug ResistanceStatistical AnalysisTuberculoseHIVResistência a MedicamentosAnálise Estatísticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11182/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALEvaluation of Two Line Probe Assays for Rapid Detection of Mycobacterium tuberculosis, Tuberculosis (TB) Drug Resistance, and Non-TB Mycobacteria in HIV-Infected Individuals with Suspected TB.pdfEvaluation of Two Line Probe Assays for Rapid Detection of Mycobacterium tuberculosis, Tuberculosis (TB) Drug Resistance, and Non-TB Mycobacteria in HIV-Infected Individuals with Suspected TB.pdfapplication/pdf604546https://www.arca.fiocruz.br/bitstream/icict/11182/2/Evaluation%20of%20Two%20Line%20Probe%20Assays%20for%20Rapid%20Detection%20of%20Mycobacterium%20tuberculosis%2c%20Tuberculosis%20%28TB%29%20Drug%20Resistance%2c%20and%20Non-TB%20Mycobacteria%20in%20HIV-Infected%20Individuals%20with%20Suspected%20TB.pdff29e8e7e3119912f0b0e353164ebe9ebMD52TEXTEvaluation of Two Line Probe Assays for Rapid Detection of Mycobacterium tuberculosis, Tuberculosis (TB) Drug Resistance, and Non-TB Mycobacteria in HIV-Infected Individuals with Suspected TB.pdf.txtEvaluation of Two Line Probe Assays for Rapid Detection of Mycobacterium tuberculosis, Tuberculosis (TB) Drug Resistance, and Non-TB Mycobacteria in HIV-Infected Individuals with Suspected 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dc.title.pt_BR.fl_str_mv Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
title Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
spellingShingle Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
Luetkemeyer, Anne F.
Tuberculosis
HIV
Drug Resistance
Statistical Analysis
Tuberculose
HIV
Resistência a Medicamentos
Análise Estatística
title_short Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
title_full Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
title_fullStr Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
title_full_unstemmed Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
title_sort Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB
author Luetkemeyer, Anne F.
author_facet Luetkemeyer, Anne F.
Kendall, Michelle A.
Wu, Xingye
Lourenço, Maria Cristina
Jentsch, Ute
Swindells, Susan
Qasba, Sarojini S.
Sanchez, Jorge
Havlir, Diane V.
Grinsztejn, Beatriz
Sanne, Ian M.
Firnhaber, Cynthia
author_role author
author2 Kendall, Michelle A.
Wu, Xingye
Lourenço, Maria Cristina
Jentsch, Ute
Swindells, Susan
Qasba, Sarojini S.
Sanchez, Jorge
Havlir, Diane V.
Grinsztejn, Beatriz
Sanne, Ian M.
Firnhaber, Cynthia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luetkemeyer, Anne F.
Kendall, Michelle A.
Wu, Xingye
Lourenço, Maria Cristina
Jentsch, Ute
Swindells, Susan
Qasba, Sarojini S.
Sanchez, Jorge
Havlir, Diane V.
Grinsztejn, Beatriz
Sanne, Ian M.
Firnhaber, Cynthia
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
HIV
Drug Resistance
Statistical Analysis
topic Tuberculosis
HIV
Drug Resistance
Statistical Analysis
Tuberculose
HIV
Resistência a Medicamentos
Análise Estatística
dc.subject.decs.pt_BR.fl_str_mv Tuberculose
HIV
Resistência a Medicamentos
Análise Estatística
description This work was supported by award number U01AI068636 from the National Institute of Allergy and Infectious Diseases and the Statistical and Data Management Center (SDMC) (UM1 AI068634) funded by the National Institute of Allergy and Infectious Diseases. A.F.L. reports research grant support to the University of California, San Francisco, from Cepheid.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-07-09T12:18:42Z
dc.date.available.fl_str_mv 2015-07-09T12:18:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LUETKEMEYER, Anne F. et al. Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB. Journal of Clinical Microbiology, v.52, n.4, p.1052-1059, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11182
dc.identifier.issn.none.fl_str_mv 0095-1137
dc.identifier.doi.none.fl_str_mv 10.1128/JCM.02639-13
dc.identifier.eissn.none.fl_str_mv 1098-660X
identifier_str_mv LUETKEMEYER, Anne F. et al. Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, Tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB. Journal of Clinical Microbiology, v.52, n.4, p.1052-1059, 2014.
0095-1137
10.1128/JCM.02639-13
1098-660X
url https://www.arca.fiocruz.br/handle/icict/11182
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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