Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11668 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, Brazil/ Universidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, Brazil |
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Macedo, Gilson CostaMelo, Adriana Bozzi deWeinreich, Helena RachelBafica, Andre Luiz BarbosaTeixeira, Henrique CoutoOliveira, Sergio Costa2015-09-02T18:07:40Z2015-09-02T18:07:40Z2011MACEDO, Gilson Costa et al. Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens. Clinical & Developmental Immunology, vol. 2011, ID 351573, 2011.1365-2249https://www.arca.fiocruz.br/handle/icict/1166810.1155/2011/351573engWiley Online LibraryHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, Brazil/ Universidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, BrazilUniversidade Federal de Juiz de Fora. Instituto de Ciencias Biologicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, BrazilTuberculosis remains a major health problem throughout the world causing large number of deaths. Effective disease control and eradication programs require the identification of major antigens recognized by the protective responses against M. tuberculosis. In this study, we have investigated humoral and cellular immune responses to M. tuberculosis-specific Ag85A, Ag85B, and ESAT-6 antigens in Brazilian patients with pulmonary (P, n = 13) or extrapulmonary (EP, n = 12) tuberculosis, patients undergoing chemotherapy (PT, n = 23), and noninfected healthy individuals (NI, n = 7). Compared to NI, we observed increased levels of IgG1 responses to Ag85B and ESAT-6 in P and PT groups. Regarding cellular immunity, Ag85A and ESAT-6 were able to discriminate P, PT, and EP patients from healthy individuals by IFN-γ production and P and PT groups from EP individuals by production of TNF-α. In summary, these findings demonstrate the ability of Ag85A, Ag85B, and ESAT-6 to differentiate TB patients from controls by IgG1, IFN-γ and TNF-α production.Tuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11668/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdfHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdfapplication/pdf5293021https://www.arca.fiocruz.br/bitstream/icict/11668/2/Human%20T-cell%20and%20antibody%20mediated%20responses%20to%20the%20Mycobacterium%20tuberculosis%20recombinant%2085A%2c%2085B%20and%20ESAT-6%20antigens.pdf2b102ed710e22b58583281d793cf3ac5MD52TEXTHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdf.txtHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/11668/3/Human%20T-cell%20and%20antibody%20mediated%20responses%20to%20the%20Mycobacterium%20tuberculosis%20recombinant%2085A%2c%2085B%20and%20ESAT-6%20antigens.pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD53icict/116682019-06-19 10:05:25.688oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:05:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens |
| title |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens |
| spellingShingle |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens Macedo, Gilson Costa Tuberculosis |
| title_short |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens |
| title_full |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens |
| title_fullStr |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens |
| title_full_unstemmed |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens |
| title_sort |
Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens |
| author |
Macedo, Gilson Costa |
| author_facet |
Macedo, Gilson Costa Melo, Adriana Bozzi de Weinreich, Helena Rachel Bafica, Andre Luiz Barbosa Teixeira, Henrique Couto Oliveira, Sergio Costa |
| author_role |
author |
| author2 |
Melo, Adriana Bozzi de Weinreich, Helena Rachel Bafica, Andre Luiz Barbosa Teixeira, Henrique Couto Oliveira, Sergio Costa |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Macedo, Gilson Costa Melo, Adriana Bozzi de Weinreich, Helena Rachel Bafica, Andre Luiz Barbosa Teixeira, Henrique Couto Oliveira, Sergio Costa |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis |
| topic |
Tuberculosis |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, Brazil/ Universidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, Brazil |
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2011 |
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2011 |
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2015-09-02T18:07:40Z |
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2015-09-02T18:07:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MACEDO, Gilson Costa et al. Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens. Clinical & Developmental Immunology, vol. 2011, ID 351573, 2011. |
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https://www.arca.fiocruz.br/handle/icict/11668 |
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1365-2249 |
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10.1155/2011/351573 |
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MACEDO, Gilson Costa et al. Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens. Clinical & Developmental Immunology, vol. 2011, ID 351573, 2011. 1365-2249 10.1155/2011/351573 |
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Wiley Online Library |
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Wiley Online Library |
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