Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells

Detalhes bibliográficos
Autor(a) principal: Carrett-Dias, Michele
Data de Publicação: 2011
Outros Autores: Votto, Ana Paula de Souza, Filgueira, Daza de Moraes Vaz Batista, Almeida, Daniela Volcan, Vallochi, Adriana Lima, D'Oca, Marcelo Gonçalves Montes, Marins, Luis Fernando, Trindade, Gilma Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40118
Resumo: Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.
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spelling Carrett-Dias, MicheleVotto, Ana Paula de SouzaFilgueira, Daza de Moraes Vaz BatistaAlmeida, Daniela VolcanVallochi, Adriana LimaD'Oca, Marcelo Gonçalves MontesMarins, Luis FernandoTrindade, Gilma Santos2020-02-25T12:48:03Z2020-02-25T12:48:03Z2011CARRET-DIAS, Michele et al. Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells. Biosci. Rep., v. 21, p. 391-398, 2011.0144-8463https://www.arca.fiocruz.br/handle/icict/4011810.1042/BSR201001151573-4935engPortland PressÁcido acetilsalicílicoAntioxidanteCélula mortaExpressão geneticaLeucemiaResistência a múltiplas drogasAcetylsalicylic acid (ASA)AntioxidantDeath cellGene expressionLeukaemiaMultidrug resistanceAnti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande. Escola de Química e Alimentos. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.ASA (acetylsalicylic acid) is an NSAID (non-steroidal anti-inflammatory drug). ASA has gained attention as a potential chemopreventive and chemotherapeutic agent for several neoplasms. The aim of this study was to analyse the possible antitumoural effects of ASA in two erythroleukaemic cell lines, with or without the MDR (multidrug resistance) phenotype. The mechanism of action of different concentrations of ASA were compared in K562 (non-MDR) and Lucena (MDR) cells by analysing cell viability, apoptosis and necrosis, intracellular ROS (reactive oxygen species) formation and bcl-2, p53 and cox-2 gene expression. ASA inhibited the cellular proliferation or induced toxicity in K562 and Lucena cell lines, irrespective of the MDR phenotype. The ASA treatment provoked death by apoptosis and necrosis in K562 cells and only by necrosis in Lucena cells. ASA also showed antioxidant activity in both cell lines. The bcl-2, p53 and cox-2 genes in both cell lines treated with ASA seem to exhibit different patterns of expression. However, normal lymphocytes treated with the same ASA concentrations were more resistant than tumoral cells. The results of this work show that both cell lines responded to treatment with ASA, demonstrating a possible antitumoral and anti-MDR role for this drug.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40118/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAdrianaLima_Valochi_etal_IOC_2011.pdfAdrianaLima_Valochi_etal_IOC_2011.pdfapplication/pdf592056https://www.arca.fiocruz.br/bitstream/icict/40118/2/AdrianaLima_Valochi_etal_IOC_2011.pdfeaf2cd07553d46a63b5af7773cab3325MD52TEXTAdrianaLima_Valochi_etal_IOC_2011.pdf.txtAdrianaLima_Valochi_etal_IOC_2011.pdf.txtExtracted texttext/plain48700https://www.arca.fiocruz.br/bitstream/icict/40118/3/AdrianaLima_Valochi_etal_IOC_2011.pdf.txtd463072fe7ba9390373a021c43e88850MD53icict/401182020-02-26 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dc.title.pt_BR.fl_str_mv Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
title Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
spellingShingle Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
Carrett-Dias, Michele
Ácido acetilsalicílico
Antioxidante
Célula morta
Expressão genetica
Leucemia
Resistência a múltiplas drogas
Acetylsalicylic acid (ASA)
Antioxidant
Death cell
Gene expression
Leukaemia
Multidrug resistance
title_short Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
title_full Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
title_fullStr Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
title_full_unstemmed Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
title_sort Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
author Carrett-Dias, Michele
author_facet Carrett-Dias, Michele
Votto, Ana Paula de Souza
Filgueira, Daza de Moraes Vaz Batista
Almeida, Daniela Volcan
Vallochi, Adriana Lima
D'Oca, Marcelo Gonçalves Montes
Marins, Luis Fernando
Trindade, Gilma Santos
author_role author
author2 Votto, Ana Paula de Souza
Filgueira, Daza de Moraes Vaz Batista
Almeida, Daniela Volcan
Vallochi, Adriana Lima
D'Oca, Marcelo Gonçalves Montes
Marins, Luis Fernando
Trindade, Gilma Santos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carrett-Dias, Michele
Votto, Ana Paula de Souza
Filgueira, Daza de Moraes Vaz Batista
Almeida, Daniela Volcan
Vallochi, Adriana Lima
D'Oca, Marcelo Gonçalves Montes
Marins, Luis Fernando
Trindade, Gilma Santos
dc.subject.other.pt_BR.fl_str_mv Ácido acetilsalicílico
Antioxidante
Célula morta
Expressão genetica
Leucemia
Resistência a múltiplas drogas
topic Ácido acetilsalicílico
Antioxidante
Célula morta
Expressão genetica
Leucemia
Resistência a múltiplas drogas
Acetylsalicylic acid (ASA)
Antioxidant
Death cell
Gene expression
Leukaemia
Multidrug resistance
dc.subject.en.pt_BR.fl_str_mv Acetylsalicylic acid (ASA)
Antioxidant
Death cell
Gene expression
Leukaemia
Multidrug resistance
description Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas. Fisiologia Animal Comparada. Rio Grande, RS, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2020-02-25T12:48:03Z
dc.date.available.fl_str_mv 2020-02-25T12:48:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARRET-DIAS, Michele et al. Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells. Biosci. Rep., v. 21, p. 391-398, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40118
dc.identifier.issn.pt_BR.fl_str_mv 0144-8463
dc.identifier.doi.none.fl_str_mv 10.1042/BSR20100115
dc.identifier.eissn.none.fl_str_mv 1573-4935
identifier_str_mv CARRET-DIAS, Michele et al. Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells. Biosci. Rep., v. 21, p. 391-398, 2011.
0144-8463
10.1042/BSR20100115
1573-4935
url https://www.arca.fiocruz.br/handle/icict/40118
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Portland Press
publisher.none.fl_str_mv Portland Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/40118/2/AdrianaLima_Valochi_etal_IOC_2011.pdf
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