Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Diego de Souza
Data de Publicação: 2021
Outros Autores: La Noval, Claudia Rodriguez de, Ferreira, Marina da Silva, Honorato, Leandro, Araújo, Glauber Ribeiro de Sousa, Frases, Susana, Pizzini, Claudia Vera, Nosanchuk, Joshua D., Cordero, Radames J. B., Rodrigues, Marcio L., Peralta, José Mauro, Nimrichter, Leonardo, Guimarães, Allan Jefferson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46336
Resumo: Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Bioquímica e Imunologia das Micoses. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.
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spelling Gonçalves, Diego de SouzaLa Noval, Claudia Rodriguez deFerreira, Marina da SilvaHonorato, LeandroAraújo, Glauber Ribeiro de SousaFrases, SusanaPizzini, Claudia VeraNosanchuk, Joshua D.Cordero, Radames J. B.Rodrigues, Marcio L.Peralta, José MauroNimrichter, LeonardoGuimarães, Allan Jefferson2021-03-11T14:16:06Z2021-03-11T14:16:06Z2021GONÇALVES, Diego de Souza et al. Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan. Frontiers in Cellular and Infection Microbiology, v. 10, n. 565571, p. 1-16, 2021.2235-2988https://www.arca.fiocruz.br/handle/icict/4633610.3389/fcimb.2020.565571engFrontiers MediaHistoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannaninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Bioquímica e Imunologia das Micoses. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Bioquímica e Imunologia das Micoses. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Bioquímica e Imunologia das Micoses. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Biofísica de Fungos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Biofísica de Fungos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Albert Einstein College of Medicine of Yeshiva University. Department of Microbiology and Immunology and Division of infectious Diseases. Bronx, NY, United States.Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology. Baltimore, MD, United States.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Bioquímica e Imunologia das Micoses. Niterói, RJ, Brasil.The cell wall is a ubiquitous structure in the fungal kingdom, with some features varying depending on the species. Additional external structures can be present, such as the capsule of Cryptococcus neoformans (Cn), its major virulence factor, mainly composed of glucuronoxylomannan (GXM), with anti-phagocytic and anti-inflammatory properties. The literature shows that other cryptococcal species and even more evolutionarily distant species, such as the Trichosporon asahii, T. mucoides, and Paracoccidioides brasiliensis can produce GXM-like polysaccharides displaying serological reactivity to GXM-specific monoclonal antibodies (mAbs), and these complex polysaccharides have similar composition and anti-phagocytic properties to cryptococcal GXM. Previously, we demonstrated that the fungus Histoplasma capsulatum (Hc) incorporates, surface/secreted GXM of Cn and the surface accumulation of the polysaccharide enhances Hc virulence in vitro and in vivo. In this work, we characterized the ability of Hc to produce cellular-attached (C-gly-Hc) and secreted (E-gly) glycans with reactivity to GXM mAbs. These C-gly-Hc are readily incorporated on the surface of acapsular Cn cap59; however, in contrast to Cn GXM, C-gly-Hc had no xylose and glucuronic acid in its composition. Mapping of recognized Cn GXM synthesis/export proteins confirmed the presence of orthologs in the Hc database. Evaluation of C-gly and E-gly of Hc from strains of distinct monophyletic clades showed serological reactivity to GXM mAbs, despite slight differences in their molecular dimensions. These C-gly-Hc and E-gly-Hc also reacted with sera of cryptococcosis patients. In turn, sera from histoplasmosis patients recognized Cn glycans, suggesting immunogenicity and the presence of cross-reacting antibodies. Additionally, C-gly-Hc and E-gly-Hc coated Cn cap59 were more resistant to phagocytosis and macrophage killing. C-gly-Hc and E-gly-Hc coated Cn cap59 were also able to kill larvae of Galleria mellonella. These GXM-like Hc glycans, as well as those produced by other pathogenic fungi, may also be important during host-pathogen interactions, and factors associated with their regulation are potentially important targets for the management of histoplasmosis.Cryptococcus neoformansGXM-likeHistoplasma capsulatumCellular-attached glycansExtracellular glycansPathogenesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
title Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
spellingShingle Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
Gonçalves, Diego de Souza
Cryptococcus neoformans
GXM-like
Histoplasma capsulatum
Cellular-attached glycans
Extracellular glycans
Pathogenesis
title_short Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
title_full Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
title_fullStr Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
title_full_unstemmed Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
title_sort Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
author Gonçalves, Diego de Souza
author_facet Gonçalves, Diego de Souza
La Noval, Claudia Rodriguez de
Ferreira, Marina da Silva
Honorato, Leandro
Araújo, Glauber Ribeiro de Sousa
Frases, Susana
Pizzini, Claudia Vera
Nosanchuk, Joshua D.
Cordero, Radames J. B.
Rodrigues, Marcio L.
Peralta, José Mauro
Nimrichter, Leonardo
Guimarães, Allan Jefferson
author_role author
author2 La Noval, Claudia Rodriguez de
Ferreira, Marina da Silva
Honorato, Leandro
Araújo, Glauber Ribeiro de Sousa
Frases, Susana
Pizzini, Claudia Vera
Nosanchuk, Joshua D.
Cordero, Radames J. B.
Rodrigues, Marcio L.
Peralta, José Mauro
Nimrichter, Leonardo
Guimarães, Allan Jefferson
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Diego de Souza
La Noval, Claudia Rodriguez de
Ferreira, Marina da Silva
Honorato, Leandro
Araújo, Glauber Ribeiro de Sousa
Frases, Susana
Pizzini, Claudia Vera
Nosanchuk, Joshua D.
Cordero, Radames J. B.
Rodrigues, Marcio L.
Peralta, José Mauro
Nimrichter, Leonardo
Guimarães, Allan Jefferson
dc.subject.en.pt_BR.fl_str_mv Cryptococcus neoformans
GXM-like
Histoplasma capsulatum
Cellular-attached glycans
Extracellular glycans
Pathogenesis
topic Cryptococcus neoformans
GXM-like
Histoplasma capsulatum
Cellular-attached glycans
Extracellular glycans
Pathogenesis
description Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Bioquímica e Imunologia das Micoses. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-03-11T14:16:06Z
dc.date.available.fl_str_mv 2021-03-11T14:16:06Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, Diego de Souza et al. Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan. Frontiers in Cellular and Infection Microbiology, v. 10, n. 565571, p. 1-16, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46336
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2020.565571
identifier_str_mv GONÇALVES, Diego de Souza et al. Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan. Frontiers in Cellular and Infection Microbiology, v. 10, n. 565571, p. 1-16, 2021.
2235-2988
10.3389/fcimb.2020.565571
url https://www.arca.fiocruz.br/handle/icict/46336
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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