Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2002 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/4057 http://dx.doi.org/10.1590/S0074-02762002000900025 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
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Lenzi, Jane A.Mota, Ester MariaMachado, Marcelo PelajoVale, Leandro S.Vale, Bruno SilvaAndrade, Zilton de AraújoLenzi, Henrique Leonel2012-05-10T16:52:15Z2012-05-10T16:52:15Z2002LENZI, Jane A. et al. Intestinal fibrovascular nodules caused by Schistosoma mansoni infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a model of concomitant fibrosis and angiogenesis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.97, sup.1, p. 117-127, 2002.0074-0276https://www.arca.fiocruz.br/handle/icict/4057http://dx.doi.org/10.1590/S0074-02762002000900025engFundação Oswaldo Cruz. Instituto Oswaldo CruzIntestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz, Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Human schistosomiasis develops extensive and dense fibrosis in portal space, together with congested new blood vessels. This study demonstrates that Calomys callosus infected with Schistosoma mansoni also develops fibrovascular lesions, which are found in intestinal subserosa. Animals were percutaneously infected with 70 cercariae and necropsied at 42, 45, 55, 80, 90 and 160 days after infection. Intestinal sections were stained for brightfield, polarization microscopy, confocal laser scanning, transmission and scanning electron microscopies. Immunohistological analysis was also performed and some nodules were aseptically collected for cell culture. Numerous intestinal nodules, appearing from 55 up to 160 days after infection, were localized at the interface between external muscular layer and intestinal serosa, consisting of fibrovascular tissue forming a shell about central granuloma(s). Intranodular new vessels were derived from the vasculature of the external vascular layer and were positive for laminin, chondroitin-sulfate, smooth muscle alpha-actin and FVIII-RA. Fibroblastic cells and extracellular matrix components (collagens I, III and VI, fibronectin and tenascin) comprised the stroma. Intermixed with the fibroblasts and vessels there were variable number of eosinophils, macrophages and haemorrhagic foci. In conclusion, the nodules constitute an excellent and accessible model to study fibrogenesis and angiogenesis, dependent on S. mansoni eggs. The fibrogenic activity is fibroblastic and not myofibroblastic-dependent. The angiogenesis is so prominent that causes haemorrhagic ascites.Calomys callosusRodentiaCricetidaeSchistosoma mansoniIntestineFibrosisNodulesAngiogenesisIntestinosSchistosoma mansoniAsbestoseNeovascularização PatológicaPatologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALIntestinal Fibrovascular Nodules.pdfIntestinal Fibrovascular Nodules.pdfapplication/pdf893023https://www.arca.fiocruz.br/bitstream/icict/4057/1/Intestinal%20Fibrovascular%20Nodules.pdfecb6b6c7941a3dc87961aae957ef9552MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4057/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTIntestinal Fibrovascular Nodules.pdf.txtIntestinal Fibrovascular Nodules.pdf.txtExtracted texttext/plain31304https://www.arca.fiocruz.br/bitstream/icict/4057/5/Intestinal%20Fibrovascular%20Nodules.pdf.txtc5681ff891a4ef81a467356108d3091dMD55THUMBNAILIntestinal Fibrovascular Nodules.pdf.jpgIntestinal Fibrovascular Nodules.pdf.jpgGenerated Thumbnailimage/jpeg2436https://www.arca.fiocruz.br/bitstream/icict/4057/4/Intestinal%20Fibrovascular%20Nodules.pdf.jpge0531b5249c330f67a3c42b2c416fdacMD54icict/40572018-04-06 09:06:41.013oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:06:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis |
| title |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis |
| spellingShingle |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis Lenzi, Jane A. Calomys callosus Rodentia Cricetidae Schistosoma mansoni Intestine Fibrosis Nodules Angiogenesis Intestinos Schistosoma mansoni Asbestose Neovascularização Patológica Patologia |
| title_short |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis |
| title_full |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis |
| title_fullStr |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis |
| title_full_unstemmed |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis |
| title_sort |
Intestinal Fibrovascular Nodules Caused by Schistosoma mansoni Infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a Model of Concomitant Fibrosis and Angiogenesis |
| author |
Lenzi, Jane A. |
| author_facet |
Lenzi, Jane A. Mota, Ester Maria Machado, Marcelo Pelajo Vale, Leandro S. Vale, Bruno Silva Andrade, Zilton de Araújo Lenzi, Henrique Leonel |
| author_role |
author |
| author2 |
Mota, Ester Maria Machado, Marcelo Pelajo Vale, Leandro S. Vale, Bruno Silva Andrade, Zilton de Araújo Lenzi, Henrique Leonel |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Lenzi, Jane A. Mota, Ester Maria Machado, Marcelo Pelajo Vale, Leandro S. Vale, Bruno Silva Andrade, Zilton de Araújo Lenzi, Henrique Leonel |
| dc.subject.en.pt_BR.fl_str_mv |
Calomys callosus Rodentia Cricetidae Schistosoma mansoni Intestine Fibrosis Nodules Angiogenesis |
| topic |
Calomys callosus Rodentia Cricetidae Schistosoma mansoni Intestine Fibrosis Nodules Angiogenesis Intestinos Schistosoma mansoni Asbestose Neovascularização Patológica Patologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Intestinos Schistosoma mansoni Asbestose Neovascularização Patológica |
| dc.subject.decs.none.fl_str_mv |
Patologia |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
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2002 |
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2002 |
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2012-05-10T16:52:15Z |
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2012-05-10T16:52:15Z |
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LENZI, Jane A. et al. Intestinal fibrovascular nodules caused by Schistosoma mansoni infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a model of concomitant fibrosis and angiogenesis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.97, sup.1, p. 117-127, 2002. |
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https://www.arca.fiocruz.br/handle/icict/4057 |
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0074-0276 |
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http://dx.doi.org/10.1590/S0074-02762002000900025 |
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LENZI, Jane A. et al. Intestinal fibrovascular nodules caused by Schistosoma mansoni infection in Calomys callosus Rengger, 1830 (Rodentia: Cricetidae): a model of concomitant fibrosis and angiogenesis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.97, sup.1, p. 117-127, 2002. 0074-0276 |
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https://www.arca.fiocruz.br/handle/icict/4057 http://dx.doi.org/10.1590/S0074-02762002000900025 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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